Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 GeneticVariation disease BEFREE Additional common variants in the APOL1-APOL4-MYH9 region do not contribute significantly to ESKD risk beyond the APOL1 G1 and G2 alleles. 26343748 2015
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 Biomarker disease BEFREE MYH9-RD is characterized by a considerable variability in clinical evolution: patients present at birth with only thrombocytopenia, but some of them subsequently develop sensorineural deafness, cataract, and/or nephropathy often leading to end-stage renal disease (ESRD). 24186861 2014
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 Biomarker disease BEFREE In addition, SNPs in other candidate loci (FRMD3 and TRPC6) trended toward association with T2D-ESKD (P(emp)<0.05). 24551085 2014
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 GeneticVariation disease BEFREE MYH9 single nucleotide polymorphisms (SNPs) have been linked to the risk for chronic kidney disease (CKD) and end stage renal disease. 23470845 2013
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 GeneticVariation disease BEFREE Association of a novel in-frame deletion mutation of the MYH9 gene with end-stage renal failure: case report and review of the literature. 22541678 2013
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 GeneticVariation disease BEFREE MYH9 SNPs rs4821480, rs2032487, rs4281481 and rs3752462 are associated with T2DM-ESRD susceptibility in European Americans. 21968013 2012
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 GeneticVariation disease BEFREE Since APOL1 is strongly associated with ESRD in African Americans, interactions between APOL1 and MYH9 risk variants and hemoglobin S were assessed using case-only and case-control centered two-way logistic regression interaction analyses. 21849968 2011
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 Biomarker disease BEFREE The myosin, heavy chain 9, non-muscle (MYH9) and apolipoprotein L1 (APOL1) genes have been associated with risk for focal segmental glomerulosclerosis and end-stage renal disease in African Americans. 21910715 2011
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 GeneticVariation disease BEFREE Admixture mapping recently identified the nonmuscle myosin heavy chain 9 gene (MYH9) as a susceptibility factor strongly associated with several nondiabetic etiologies of end-stage renal disease in African Americans, less strongly with diabetes-associated end-stage renal disease. 21074826 2011
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 GeneticVariation disease BEFREE Based on a large Chinese IgAN cohort, we found an association between rs11089788 and prognosis of IgAN, adding to the mounting evidence of MYH9 as an important gene in IgAN to ESRD. 21245129 2011
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 GeneticVariation disease BEFREE Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans. 21698141 2011
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 GeneticVariation disease BEFREE These findings strengthen the contention that a sequence variant of MYH9, common in populations with varying degrees of African ancestry admixture, and in strong linkage disequilibrium with the associated SNPs and haplotypes reported herein, strongly predisposes to non-diabetic ESKD. 20144966 2010
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 GeneticVariation disease BEFREE The spectrum of MYH9-associated kidney disease, including focal segmental glomerulosclerosis, global glomerulosclerosis and collapsing glomerulopathy, related entities contributing to approximately 43% of end-stage renal disease in African-Americans, has come to light. 19838113 2010
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 Biomarker disease BEFREE We demonstrate strong association between non-DM ESRD in African Americans with MYH9, and have identified additional candidate loci. 20532800 2010
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 GeneticVariation disease BEFREE Dense mapping of MYH9 identified individual single nucleotide polymorphisms (SNPs) and sets of such SNPs grouped as haplotypes that were found to be highly associated with a large and important group of ESKD risk phenotypes, which as a consequence were designated as MYH9-associated nephropathies (Bostrom and Freedman 2010). 20635188 2010
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 GeneticVariation disease BEFREE The contribution of variants in this single MYH9 gene to ethnic differences in the incidence rates of end-stage renal disease is now clearly established. 20492585 2010
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 Biomarker disease BEFREE Admixture mapping recently identified MYH9 as a susceptibility gene for idiopathic focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy (HIVAN) and end-stage kidney disease attributed to hypertension (H-ESKD) in African Americans (AA). 20124285 2010
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 GeneticVariation disease BEFREE Thus, hypertension-associated ESRD in African Americans is substantially related to MYH9 gene polymorphisms and this may explain the poor response to blood pressure control in those diagnosed with hypertensive nephrosclerosis. 19177153 2009
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 Biomarker disease BEFREE Genetic dissection of T2DM-associated ESRD reveals that MYH9 underlies a portion of this clinically diagnosed disorder in African Americans. 19567477 2009
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 GeneticVariation disease BEFREE Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans. 18794854 2008
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 Biomarker disease CTD_human Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans. 18794854 2008
Entrez Id: 4627
Gene Symbol: MYH9
MYH9
0.400 Biomarker disease CTD_human MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. 18794856 2008