Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE TRAIL is currently under investigation for the treatment of leukemia. 30257312 2018
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 AlteredExpression disease BEFREE Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) down-regulation by preferentially expressed antigen of melanoma (PRAME) is a general phenomenon in different types of solid tumours, but research on the correlation between PRAME and TRAIL gene expression in leukaemia patients is rare. 24008770 2013
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 AlteredExpression disease BEFREE BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome-positive leukemia. 22665066 2013
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE It enhanced cytotoxicity in TRAIL-treated K562 leukemia cells and reduced TRAIL-induced apoptosis in HCT116 and SW480 colon cancer cells, while having no effect on PC3 and LNCaP cells. 22462553 2012
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Here we investigated whether TRAIL targets leukemia-initiating cells. 22408264 2012
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Overall, HDACi represent a promising and safe strategy in combination with TRAIL for treatment of T-cell leukaemia. 20580868 2010
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 AlteredExpression disease BEFREE Effective gene-viral therapy of leukemia by a new fiber chimeric oncolytic adenovirus expressing TRAIL: in vitro and in vivo evaluation. 19417152 2009
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 AlteredExpression disease BEFREE Expression of the TRAIL receptors in blood mononuclear cells in leukemia. 18158563 2007
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Therapeutic disease CTD_human [Combined effect of recombinant mutant human TRAIL and daunorubicin in inducing apoptosis of leukemia cell and its mechanism]. 17204177 2006
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease LHGDN Our study demonstrates that RA induction of the TRAIL pathway is also operative in leukemia cells lacking an RARalpha oncofusion protein and identifies RAM as a novel RA-dependent modulator of myeloid differentiation and death. 16449964 2006
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 GeneticVariation disease BEFREE In summary, constitutive TRAIL susceptibility differs between leukemia subtypes and does not correlate with mRNA expression levels of the TRAIL receptors R1-R4 as well as constitutive NF-kappa B activation status. 11417478 2001
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE These data suggest that TRAIL might participate in CD95-independent apoptosis of lymphoid cells and might be involved in deregulated apoptosis in diseases such as leukemias and HIV-1 infection. 9485194 1998