Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker disease BEFREE Inhibition of novel GCN5-ATM axis restricts the onset of acquired drug resistance in leukemia. 29297932 2018
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker disease RGD A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype. 28007901 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker disease GENOMICS_ENGLAND Germline Genetic Predisposition to Hematologic Malignancy. 28297620 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker disease BEFREE Collectively, these data indicated that ATR or ATM inhibition represent potential therapeutic strategies for the treatment of AML, especially MLL-driven leukemias. 27625305 2016
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation disease BEFREE Both A-T and T-cell prolymphoblastic leukemia patients with somatic mutations of ATM frequently carry inv(14;14) between the T-cell receptor α/δ (TCRα/δ) and immunoglobulin H loci, but the molecular origin of this translocation remains elusive. 25721125 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation disease BEFREE Biallelic inactivation of the ATM gene causes ataxia-telangiectasia (A-T), a complex neurological disease associated with a high risk of leukaemias and lymphomas. 19404735 2010
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation disease BEFREE The mutations in the ATM gene may be involved in the development of some subtypes of sporadic lymphomas and leukemias. 17516749 2007
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation disease BEFREE We show that the residual ATM allele is mutated in 36% of CLLs with an 11q deletion and that these leukemias demonstrate an impaired cellular response to irradiation or cytotoxic drug exposure in vitro. 17968022 2007
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker disease LHGDN Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR. 17030982 2006
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation disease BEFREE ATM mutations have been reported in adult sporadic lymphoma and leukaemia. 14735203 2004
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation disease BEFREE Inherited biallelic mutations of the ATM (ataxia-telangiectasia mutated) gene cause ataxia-telangiectasia, a rare autosomal recessive disorder associated with a high incidence of childhood leukaemias and lymphomas, suggesting that ATM gene alterations may be involved in lymphomagenesis. 14628072 2004
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker disease BEFREE Our finding in this patient suggests that altered function of ATM plays some pathogenic roles in the development of MLL(+) leukemia. 12511424 2003
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker disease LHGDN Our finding in this patient suggests that altered function of ATM plays some pathogenic roles in the development of MLL(+) leukemia. 12511424 2003
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation disease BEFREE This, coupled with a possibly increased risk of leukaemia in relatives of patients with Ataxia Telangiectasia, led us to question whether the ATM gene is involved in familial cases of CLL. 10516748 1999
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation disease BEFREE A role for ATM in the development of sporadic T-cell chronic leukemias is supported by the finding of loss of heterozygosity at 11q22-23 and ATM mutations in leukemias carrying TCL-1 rearrangements. 9892178 1999
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation disease BEFREE T-prolymphocytic leukaemia (T-PLL) is a rare, sporadic leukaemia similar to a mature T-cell leukaemia seen in some patients with Ataxia Telangiectasia (A-T), a recessive multisystem disorder caused by mutations of the ATM gene at chromosome 11q23. 9488043 1998
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker disease BEFREE The absence of somatic nucleotide changes in ATM in T-ALL as compared with T-PLL suggests a distinct pattern of genetic events in the development of the two leukemias. 9622061 1998
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GeneticVariation disease BEFREE ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer. 9463314 1998
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 CausalMutation disease CGI
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 Biomarker disease HPO
Entrez Id: 472
Gene Symbol: ATM
ATM
0.900 GenomicAlterations disease CGI
Entrez Id: 2177
Gene Symbol: FANCD2
FANCD2
0.620 Biomarker disease GENOMICS_ENGLAND Germline Genetic Predisposition to Hematologic Malignancy. 28297620 2017
Entrez Id: 2177
Gene Symbol: FANCD2
FANCD2
0.620 Biomarker disease BEFREE Involvement of Fanconi anemia genes FANCD2 and FANCF in the molecular basis of drug resistance in leukemia. 25647473 2015
Entrez Id: 2177
Gene Symbol: FANCD2
FANCD2
0.620 GeneticVariation disease BEFREE Frameshift-like mutations were also observed in the NF1 and FANCD2 genes that are associated with genetic conditions conferring a predisposition to leukemia. 15886296 2005
Entrez Id: 2177
Gene Symbol: FANCD2
FANCD2
0.620 GenomicAlterations disease CGI