Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 AlteredExpression disease BEFREE Arguably the MYC activity gain is the most constantly observed phenomenon (>70% of cases) in transformed FL/MALT/CLL (Richter's transformation) and co-occurs with specific aberrations such as the loss of p53, CDKN2A/B, or gain of BCL2/BCL6. 31631728 2020
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Spontaneously regressed CLL displayed a transcriptome profile characterized by downregulation of metabolic processes as well as MYC and its downstream targets compared to non-regressing CLL. 31794600 2020
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Accordingly, siRNA-mediated downregulation of either <i>EZH2, MYC</i> or <i>IGF1R</i> and treatment with EZH2 and MYC pharmacological inhibitors in the HG3 CLL cell line induced a significant reduction in PI3K pathway activation. 31216925 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE In conclusion, NOTCH1 mutations in CLL are associated with the overexpression of MYC and MYC-related genes involved in protein biosynthesis including NPM1, which are allegedly responsible for cell growth and/or proliferation advantages of NOTCH1-mut CLL. 28321119 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE The clinical significance of 8q24/MYC rearrangement in chronic lymphocytic leukemia. 26916070 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Additionally, following downregulation of Notch 2 protein expression, the protein expression levels of phospho‑mitogen‑activated protein kinase 1 (p‑ERK), v‑myc avian myelocytomatosis viral oncogene homolog and B‑cell CLL/lymphoma 2 (Bcl2) were also downregulated, whereas, Bcl2‑associated X protein expression was upregulated. 27572051 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE In this issue of Blood, Yeomans et al identify MYC as an important target for translational regulation in chronic lymphocytic leukemia (CLL) cells after B-cell receptor (BCR) stimulation and show that current therapies suppress this induction. 26823509 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Additionally, MYC rearranged CLL presented as outstanding group by often showing a non-complex karyotype (85%), absence of ID3 mutations, a high frequency of SF3B1 mutations, and a frequent involvement of non-immunoglobulin loci as MYC-partner genes (61%). 27810071 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 AlteredExpression disease BEFREE These include previously unrecognized putative cancer drivers (RPS15, IKZF3), and collectively identify RNA processing and export, MYC activity, and MAPK signalling as central pathways involved in CLL. 26466571 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Genome-wide association studies (GWAS) have identified that a ∼1 M region centromeric to the MYC oncogene on chromosome 8q24.21 harbors at least five independent loci associated with prostate cancer risk and additional loci associated with cancers of breast, colon, bladder, and chronic lymphocytic leukemia (CLL). 24783269 2014
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 AlteredExpression disease BEFREE CLL cells respond to B-Cell receptor stimulation with a microRNA/mRNA signature associated with MYC activation and cell cycle progression. 23560086 2013
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE MYC translocations were observed in 2 cases transformed from a CLL. 23282972 2013
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Our findings implicate amplifications of 3q26 focused on PIK3CA and 8q24 focused on MYC in CLL. 22623730 2012
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Our results suggest that ERK1/2-dependent induction of MYC is likely to play an important role in antigen-induced CLL cell proliferation. 22086413 2012
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 GeneticVariation disease BEFREE We report the characteristics of 21 patients with CLL and nine patients with prolymphocytic leukemia (PLL), diagnosed in multiple centers (n = 13), which showed an MYC translocation demonstrated by fluorescence in situ hybridization.The prevalence was estimated to be <1%. 22205151 2012
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE This study reveals an important relationship between BAFF and c-MYC in CLL which may affect disease development and progression, and suggests that inhibitors of the canonical NF-κB pathway may be effective in treatment of patients with this disease. 20956327 2010
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 AlteredExpression disease BEFREE Resistant CLL demonstrated baseline low p27 and high c-Myc protein levels and increased pSyk, indicative of an activated phenotype. 20817072 2010
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 GeneticVariation disease BEFREE Based upon these results, we propose for the first time that miR-196b has the inherent capacity to down-regulate the overamplified c-myc gene recognized as a common pathognomonic feature leading to cancer in general and B-cell ALL in particular. 20549547 2010
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE A deregulation of MYC pathway might represent one of the main transformation events in the pathogenesis of a subset of RS clonally related to the previous CLL. 20014148 2010
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 GeneticVariation disease BEFREE U-2973, a novel B-cell line established from a patient with a mature B-cell leukemia displaying concurrent t(14;18) and MYC translocation to a non-IG gene partner. 18510704 2008
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 GeneticVariation disease BEFREE We report the clinical, morphological, immunophenotypic, cytogenetic and molecular genetic features of eight CLL cases with MYC rearrangement. 18477041 2008
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE The rarity of t(8;14) in CLL together with a cryptic deletion that probably includes the MYC gene in our CLL patient persuaded us to explore the clinicopathological role of MYC translocations by comparing disease progression in our patient and in other reported CLL cases. 16616107 2006
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 GeneticVariation disease BEFREE Translocations involving an overexpressed c-myc gene are also found in AIDS-associated lymphoma or in T cell leukaemias, or they develop during tumour progression of a low grade B cell malignancy into a high grade B cell tumour in an additional cytogenetic change. 8142618 1993
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 GeneticVariation disease BEFREE A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia. 2069907 1991
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 AlteredExpression disease BEFREE Because the numbers of peripheral blood lymphoma cells were independent of tumor mass and of c-myc gene transcripts expressed, peripheral blood lymphocytosis might more likely reflect homing processes than proliferative activity in CLL. 2070052 1991