Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Our B-ALL fluorescence in situ hybridization (FISH) panel confirmed the BCR/ABL1 fusion and monosomies consistent with chromosome studies in approximately 95% of interphase nuclei. 30790375 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis. 31173268 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Four patients presented with B-lymphoblastic leukemia (B-ALL), and of them, two patients with t(8;9)(p22;p24.1) were proven to be B-lymphoblastic crisis of MPN; and the other two cases with t(9p24;v) both were de novo B-ALL, BCR-ABL1-like (Ph-like). 30401948 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia. 23399893 2013
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Inducible genetic attenuation of BCR-ABL reversed Bmi1-driven B-ALL development, which was accompanied by induction of apoptosis of leukemic B-lymphoid progenitors and by long-term animal survival, suggesting that BCR-ABL is required to maintain B-ALL and that BCR-ABL and Bmi1 cooperate toward blast transformation in vivo. 22101899 2012
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE RCSD1-ABL1-positive B lymphoblastic leukemia is sensitive to dexamethasone and tyrosine kinase inhibitors and rapidly evolves clonally by chromosomal translocations. 21863287 2011
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Recurrent genetic abnormalities in B-lymphoblastic leukemia with prognostic significance are well known and specifically delineated in the WHO 2008 classification (eg hyperdiploidy, t(9;22)(q34;q11.2); BCR-ABL1, t(12;21)(p13;q22); ETV6-RUNX1). 21822204 2011
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Notably, genetic alteration of the lymphoid transcription factor gene IKZF1 is a hallmark of multiple subtypes of ALL with poor prognosis, including BCR-ABL1-positive lymphoid leukemia and a subset of 'BCR-ABL1-like' ALL cases that, in addition to IKZF1 alteration, harbor genetic mutations resulting in aberrant lymphoid cytokine receptor signaling, including activating mutations of Janus kinases and rearrangement of cytokine receptor-like factor 2 (CRLF2). 20739952 2010
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE The spectrum of adult B-lymphoid leukemias with BCR-ABL: molecular diagnostic, cytogenetic, and clinical laboratory perspectives. 18932238 2008
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Since BACH2 induces apoptosis by oxidative stress, these observations suggest that down-regulation of the BACH2 gene through the interaction with centromeric heterochromatin would take part in leukomogenesis of BCR-ABL positive lymphoid leukemia. 17044046 2007
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Using a murine model of chronic myeloid leukemia, an adult-onset malignancy that arises from transformation of hematopoietic stem cells by the BCR-ABL(P210) oncogene, we demonstrate that young bone marrow (BM) cells that were transformed with BCR-ABL(P210) initiated both a myeloproliferative disorder (MPD) and B-lymphoid leukemia, whereas BCR-ABL(P210)-transformed old BM cells recapitulated the human disease by inducing an MPD with rare lymphoid involvement. 17554060 2007
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells. 16205638 2006
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE In contrast, recent observations in human BCR-ABL1(+) pre-B lymphoblastic leukemia cells demonstrate that Btk is constitutively phosphorylated and activated by the BCR-ABL1 fusion protein. 16300960 2006
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: a prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis. 11861265 2002
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE The human BCR-ABL oncogenes encoded by the Philadelphia chromosome (Ph) affect the pathogenesis of diverse types of leukemia and yet are rarely associated with T-lymphoid leukemia. 8396667 1993