Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE To analyze influence of variants in TYMS, MTHFR, SLC19A1 and DHFR genes on 6-mercaptopurine (MP) induced toxicity during maintenance phase of treatment for childhood acute lymphocytic leukemia (ALL). 31786878 2020
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE Our objective was to determine the association between the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) and the risk of developing acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), acute myeloid leukemia (AML), and multiple myelomas (MM) in Latinos. 31188929 2019
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE Our investigation revealed that the 5,10-MTHFR 677 C/T and 5,10-MTHFR 677T/T genotypes are associated with susceptibility to pediatric ALL (OR = 1.9, 95% IC = 1.36-12.09, p = 0.012 and OR = 2.8, 95% CI = 1.49-22.82, p = 0.011, respectively). 31499477 2019
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE Our findings suggest that C677T polymorphism of MTHFR seems to be a good marker for MTX-related toxicity in ALL. 30545275 2019
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE The results indicated that the mRNA expression level of MTRR in the bone marrow from children with ALL was lower than that in the control samples (P<0.05), but no significant difference was detected in the MTHFR gene between the two groups (P>0.05). 31002356 2019
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 Biomarker disease BEFREE This study was to investigate new genetic biomarkers for ALL by analyzing the MTHFR polymorphisms at the 3'-untranslated region, which is a location bound by miRNAs. 31737664 2019
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE Genotyping for MTHFR rs3737966 and rs35134728 in 144 children with ALL was performed using the Sequenom MassArray system (Sequenom, San Diego, CA, USA). 28990296 2017
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE The observed frequency of carriers of this rare haplotype was 12%, including 677CT/1298CC (1.7%), 677TT/1298AC (6.0%), and 677CT/1298AC (4.3%) genotypes.The MTHFR 677T allele alone or in combination with the MTHFR 1298C allele significantly increases the risk of development of ALL in Polish population under 18 years of age. 29390492 2017
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE We did not find any haplotype between the rs1801133 and rs1801131 associated with ALL risk. rs1801133 and rs1801131 within MTHFR gene and their interaction were both associated with ALL risk in Chinese children. 27996344 2017
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE Two single-nucleotide polymorphisms in <i>MTHFR</i> gene, C677T and A1298C, affecting MTHFR activity, have been widely studied as potential markers of MTX toxicity and/or outcome in pediatric ALL. 28392709 2017
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE Due to the importance of the transport P-glycoprotein and methylenetetrahydrofolate reductase in the metabolism of chemotherapeutic agents, we analyzed the MDR1 rs1045642 and MTHFR rs1801133 polymorphisms and their associations with clinical outcomes in Mexican childhood ALL patients. 27533339 2016
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE In summary, this meta-analysis suggests that MTHFR C677T polymorphism is associated with increased breast cancer, gastric cancer, and hepatocellular cancer risk in Asians, is associated with increased gastric cancer, multiple myeloma, and NHL risk in Caucasians, is associated with decreased AALL risk in Caucasians, is associated with decreased CALL risk in Asians, is associated with increased breast cancer risk in Asians, is associated with decreased colon cancer risk, and is associated with decreased colorectal cancer risk in male population. 26081619 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE The aim of this study was to evaluate the influence of the most common genetic variants in methylenetetrahydrofolate reductase (MTHFR), thiopurine methyltransferase (TPMT) and glutathione-S-transferases (GSTs) on the outcome of acute lymphoblastic leukemia (ALL) treatment in Argentinean children. 25110820 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE Our results indicated that the MTHFR C677T T allele was a protective biomarker for childhood ALL in Taiwan, and the association was more significant in male patients and in patients 3.5 years of age or older at onset of disease. 25793509 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 AlteredExpression disease BEFREE The effect of serum folate levels and methylenetetrahydrofolate reductase (MTHFR) genotype on complications and outcome of induction chemotherapy in 150 children with acute lymphoblastic leukemia (ALL) was studied. 25065700 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 Biomarker disease BEFREE Moreover, significantly decreased susceptibility to ALL was observed for MTHFR TA (p=0.030) and RAD51 GTT haplotypes (p=0.016). 25746326 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE The aim of our study was to investigate the influence of C677T and A1298C polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene on MTX-induced toxicity during treatment of children with ALL. 26528799 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE Our findings suggest that MTHFR C677T and A1298C polymorphisms are unlikely to affect the development of childhood ALL in an Egyptian population from Delta. 25629981 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE The aims of this study were to (a) to determine the prevalence of seven common genetic polymorphisms including those that affect the folate and/or thiopurine metabolic pathways, i.e. cyclin D1 (CCND1-G870A), γ-glutamyl hydrolase (GGH-C452T), methylenetetrahydrofolate reductase (MTHFR-C677T and MTHFR-A1298C), thymidylate synthase promoter (TYMS-TSER), thiopurine methyltransferase (TPMT*3A and TPMT*3C) and inosine triphosphate pyrophosphatase (ITPA-C94A), in Caucasian (n = 94, age < 20) and Vietnamese (n = 141, age < 16 years) childhood ALL and (b) to assess the impact of a multilocus genetic risk score (MGRS) on relapse-free survival (RFS) using a Cox proportional-hazards regression model. 25099492 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 AlteredExpression disease BEFREE To investigate the correlation between common genetic polymorphisms of folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), and methylenetetrahydrofolate reductase (MTHFR) and serum levels of methotrexate (MTX) in Chinese children with acute lymphoblastic leukemia (ALL). 24908438 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE Our results suggest that the MTHFR C677T and A1298C polymorphisms may be potential biomarkers for ALL risk in Chinese populations, and studies with a larger sample size and wider population spectrum are required before definitive conclusions can be drawn. 25342508 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE MTHFR (677 and 1298) genotype of children with ALL and healthy adult controls were done by the PCR-restriction fragment length polymorphism (PCR-RFLP) method and were compared using various models of inheritance. 24919644 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE Lack of association between polymorphisms in genes MTHFR and MDR1 with risk of childhood acute lymphoblastic leukemia. 25520092 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE We searched PubMed/MEDLINE, Scopus and ISI Web of Knowledge literature databases without language restrictions to identify observational studies among children diagnosed between ages 0 and 19 years that assessed MTHFR 677 polymorphisms in relation to ALL survival. 23550988 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation disease BEFREE However, a significant association was detected between the MTHFR A1298C/ RFC G80A genotype and a nonpredisposition for ALL (P = 0.035). 24237708 2014