Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6573
Gene Symbol: SLC19A1
SLC19A1
0.380 Biomarker disease BEFREE To analyze influence of variants in TYMS, MTHFR, SLC19A1 and DHFR genes on 6-mercaptopurine (MP) induced toxicity during maintenance phase of treatment for childhood acute lymphocytic leukemia (ALL). 31786878 2020
Entrez Id: 6573
Gene Symbol: SLC19A1
SLC19A1
0.380 GeneticVariation disease BEFREE Genotyping for SLC19A1 rs1051296 G>T in 131 children with ALL was performed using the Sequenom MassArray system. 24927955 2014
Entrez Id: 6573
Gene Symbol: SLC19A1
SLC19A1
0.380 GeneticVariation disease BEFREE There was evidence that the minor alleles of NOS3 rs3918186 (OR = 2.16; 95% CI: 1.51-3.15) and SLC19A1 rs1051266 (OR = 2.07; 95% CI: 1.25-3.46) were positively associated with childhood ALL. 24367687 2013
Entrez Id: 6573
Gene Symbol: SLC19A1
SLC19A1
0.380 GeneticVariation disease BEFREE The combination of SLC19A1 80GA heterozygosity and 3'-TYMS -6bp/-6bp homozygous deletion is associated with reduced ALL risk in Malay boys. 19651439 2010
Entrez Id: 6573
Gene Symbol: SLC19A1
SLC19A1
0.380 GeneticVariation disease BEFREE Sixteen single nucleotide polymorphisms (SNPs) (CYP3A4*1B A>G, CYP3A5*3 G>A, GSTP1 313 A>G, GSTM1 deletion, GSTT1 deletion, MDR1 exon 21 G>T/A, MDR1 exon 26 C>T, MTHFR 677 C>T, MTHFR 1298 A>C, NR3C1 1088 A>G, RFC 80 G>A, TPMT 238 G>C, TPMT 460 G>A, TPMT 719 A>G, VDR intron 8 G>A, VDR FokI T>C) that have been implicated in the pharmacogenetics of ALL therapy were analyzed by TotalPlex amplification and SNP genotyping. 18385010 2008
Entrez Id: 6573
Gene Symbol: SLC19A1
SLC19A1
0.380 Biomarker disease CTD_human Our results strongly suggest the prognostic importance of hRFC gene expression to treatment outcomes in pediatric ALL. 17255265 2007
Entrez Id: 6573
Gene Symbol: SLC19A1
SLC19A1
0.380 Biomarker disease BEFREE We found significantly lower expression of the reduced folate carrier (SLC19A1, an MTX uptake transporter) in E2A-PBX1 ALL, significantly higher expression of breast cancer resistance protein (ABCG2, an MTX efflux transporter) in TEL-AML1 ALL, and lower expression of FPGS (which catalyzes formation of MTXPG) in T-lineage ALL, consistent with lower MTXPG accumulation in these ALL subtypes. 15630450 2005
Entrez Id: 6573
Gene Symbol: SLC19A1
SLC19A1
0.380 GeneticVariation disease BEFREE We have identified an hRFC gene point mutation in a transport-defective CCRF-CEM human T-ALL cell line resulting in a lysine to glutamic acid substitution at codon 45 (E45K), which has been identified in other antifolate-resistant sublines (JBC 273:30 189, 1998; JBC 275:30 855, 2000). 12454742 2002
Entrez Id: 6573
Gene Symbol: SLC19A1
SLC19A1
0.380 AlteredExpression disease BEFREE Our results suggest that RFC gene expression is far more predictive of methotrexate uptake capacity in B-precursor than T-ALL and that increased copies of chromosome 21 in B-precursor ALL blasts are generally associated with increased RFC transcripts. 9748136 1998