Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 GeneticVariation disease BEFREE Activating mutations of the KIT receptor tyrosine kinase are frequently detected in core-binding factor AML and are associated with a greater risk of relapse. 31311917 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 GeneticVariation disease BEFREE This is typified by midostaurin, which has been approved by the US Food and Drug Administration for mutant FLT3-positive AML and for KIT D816V-positive SM. 31309543 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 GeneticVariation disease BEFREE SM developing AML without a KIT D816 mutation may be not necessarily associated with a poor prognosis. 30044348 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 Biomarker disease BEFREE Targeted therapies designed to eliminate AE and c-KIT oncoproteins may facilitate effective treatment of t(8; 21) AML. 30206768 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 GeneticVariation disease BEFREE Permanently active KIT mutations lead these host cells to tumorigenesis, and to such diseases as mast cell leukemia (MCL), gastrointestinal stromal tumor (GIST), and acute myeloid leukemia (AML). 31484543 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 Biomarker disease BEFREE Bone marrow flowcytometric analysis showed myeloblast count of 74%, which expressed CD13, CD33, CD117 and HLA-DR. A diagnosis of AML (M2 type) was made and vulvar MS was the earliest symptom. 31699112 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 Biomarker disease BEFREE Our results proved that HOTAIR, miR-193a, and c-kit genes are independent prognostic predictors in 12p chromosomal associated AML; therefore it may represent a novel therapeutic application in AML in the future. 31038787 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 GeneticVariation disease BEFREE Trisomy 4 is a rare numerical abnormality in AML patients with t (8;21), which can be associated with c-KIT gene involvement. 30899636 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 Biomarker disease BEFREE The receptor tyrosine kinase C-KIT confers critical proliferative signals to AML. 30852180 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 Biomarker disease BEFREE Two Receptors, Two Isoforms, Two Cancers: Comprehensive Analysis of KIT and TrkA Expression in Neuroblastoma and Acute Myeloid Leukemia. 31681584 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 Biomarker disease BEFREE In our study, we compared the cytogenetic changes and gene mutations (NPM1, CEBPA, DNMT3A, FLT3-ITD, FLT3-TKD, and C-KIT) with clinical outcomes in 1132 patients with AML enrolled at our center over a 10-year period. 30503388 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 AlteredExpression disease BEFREE In this study, we evaluated the role of 5mC and 5hmC levels in HL60 AML cells and bone marrow samples from AML patients for KIT gene expression to analyze 5hmC level in AML pathogenesis. 30972998 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 Biomarker disease BEFREE A screen of two independent AML databases (AML<sup>databases</sup>) revealed remarkable similarities between KIT D816<sup>mut</sup>/CBF<sup>neg</sup> SM-AML and KIT D816<sup>mut</sup>/CBF<sup>neg</sup> AML<sup>databases</sup> (n = 69) with regard to KIT D816<sup>mut</sup> variant allele frequency, mutation profile, aberrant karyotype, and OS suggesting underlying SM in a significant proportion of AML<sup>databases</sup> patients. 30635631 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 AlteredExpression disease BEFREE We used the dual-luciferase and ChIP assays to demonstrate that the RUNX1-ETO protein epigenetically trans-activates c-KIT by binding to the c-KIT promoter and recruiting the histone acetyltransferase P300 to the c-KIT promoter, elucidating the mechanism of the abnormally increased c-KIT expression in t(8;21) AML patients. 30637949 2019
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 AlteredExpression disease BEFREE In patients with t(8;21) AML, KIT mutational status was associated with miR-130a expression-with higher expression associated with KIT activating mutations. 29493383 2018
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 Biomarker disease BEFREE Nobiletin Down-Regulates c-KIT Gene Expression and Exerts Antileukemic Effects on Human Acute Myeloid Leukemia Cells. 30507186 2018
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 AlteredExpression disease BEFREE Mechanistically, PPI significantly reduced the expression of C-KIT, another therapeutic target for AML with t(8;21), followed by inhibition of Akt signaling. 30194712 2018
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 Biomarker disease BEFREE Like midostaurin, the metabolites potently inhibit mutant forms of FLT3 and KIT and several additional kinases that either are directly involved in the deregulated signaling pathways or have been implicated as playing a role in AML via stromal support, such as IGF1R, LYN, PDPK1, RET, SYK, TRKA, and VEGFR2. 30148617 2018
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 GeneticVariation disease BEFREE The KIT mutation was analyzed for core-binding factor AML. 30082223 2018
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 AlteredExpression disease BEFREE Gene expression analyses verify that c-KIT expression is significantly high in t(8;21) AML. 29236325 2018
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 GeneticVariation disease BEFREE The National Comprehensive Cancer Network (NCCN) defines the following types of acute myeloid leukemia (AML) as favorable-risk: acute promyelocytic leukemia with t(15;17) (APL); AML with core-binding factor (CBF) rearrangements, including t(8;21) and inv(16) or t(16;16) without mutations in KIT (CBF-KIT<sup>wt</sup>); and AML with normal cytogenetics and mutations in NPM1 (NPM1<sup>mut</sup>); or biallelic mutations in CEBPA (CEBPA<sup>mut/mut</sup>), without FLT3-ITD. 29310020 2018
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 GeneticVariation disease BEFREE The prevalence and clinical relevance of KIT mutations in childhood core-binding factor (CBF) acute myeloid leukemia (AML) have not been well characterized. 28792268 2018
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 Biomarker disease BEFREE Furthermore, we found that the role of IL1RAP is not restricted to the IL-1 receptor pathway, but that IL1RAP physically interacts with and mediates signaling and pro-proliferative effects through FLT3 and c-KIT, two receptor tyrosine kinases with known key roles in AML pathogenesis. 29773641 2018
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 AlteredExpression disease BEFREE <b>Purpose:</b> c-KIT overexpression is well recognized in cancers such as gastrointestinal stromal tumors (GIST), small cell lung cancer (SCLC), melanoma, non-small cell lung cancer (NSCLC), and acute myelogenous leukemia (AML). 29764854 2018
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.800 Biomarker disease BEFREE Furthermore, the investigation of lncRNAs in these prognostic modules suggested that an lncRNA (ZNF571-AS1) may be involved in AML via the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway by regulating KIT and STAT5. 28204819 2017