Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease BEFREE This study showed that cooperation of DNMT3A mutation and NRAS mutation could promote the onset of AML by synergistically disturbing the transcriptional profiling with Myc pathway involvement in DKI mice. 31703632 2019
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease BEFREE However, NRAS mutations may be a key prognostic marker related with poor survival for children with AML. 30194935 2019
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 PosttranslationalModification disease BEFREE Taken together, our findings provide new insight into the mechanism of wogonoside-induced nuclear translocation of PLSCR1 and illuminate the influence of N-RAS depalmitoylation on its Golgi trafficking and RAF1 signalling inactivation in AML. 29377576 2018
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease BEFREE First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia. 30153003 2018
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 Biomarker disease BEFREE Our findings demonstrate that Ras oncogene-independent activation of RALB signaling is a therapeutically targetable mechanism of escape from NRAS oncogene addiction in AML. 27991934 2017
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease BEFREE Somatic mutations in TP53 and NRAS are associated with transformation of human chronic myeloid diseases to acute myeloid leukemia (AML). 27815262 2017
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 Biomarker disease CTD_human Dynamics of clonal evolution in myelodysplastic syndromes. 27992414 2017
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease BEFREE AML1-ETO (AE), a fusion oncoprotein generated by t(8;21), can trigger acute myeloid leukemia (AML) in collaboration with mutations including c-Kit, ASXL1/2, FLT3, N-RAS, and K-RAS. 28381396 2017
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease BEFREE Our results show that molecular complementarity underlies the higher frequency and significantly worse prognosis associated with <i>NPM1</i>c/<i>FLT3-ITD</i> vs <i>NPM1/NRAS-G12D-</i>mutant AML and functionally confirm the role of <i>HOXA</i> genes in NPM1c-driven AML. 28835438 2017
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 Biomarker disease BEFREE On the other hand, state 2 may be associated with melanoma and other cancers where N-Ras is a major contributor, such as acute myeloid leukemia. 26659836 2016
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 Biomarker disease BEFREE Here, we found that inhibition of the kinase ATR, which is the primary sensor of DNA replication stress, induced chromosomal breakage and death of mouse AML(MLL) cells (with an MLL-ENL fusion and a constitutively active N-RAS independently of p53. 27625305 2016
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease BEFREE In phase 2, this study accrued patients with relapsed/refractory acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS) with NRAS or KRAS mutations (cohort 1); patients with AML, MDS, or chronic myelomonocytic leukemia (CMML) with a RAS wild-type mutation or an unknown mutation status (cohort 2); and patients with CMML with an NRAS or KRAS mutation (cohorts 3). 26990290 2016
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease BEFREE The frequency of NRAS mutation was four times higher than that of KRAS mutation in AML. 26222068 2015
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 Biomarker disease BEFREE One of the compounds identified, GNF-7, potently and selectively inhibited NRAS-dependent cells in preclinical models of acute myelogenous leukemia and acute lymphoblastic leukemia. 25833960 2015
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 Biomarker disease BEFREE Mutations in FLT3, DNMT3A, NRAS, NF1 and TP53 occur in persons of predominately European descent with acute myeloid leukemia (AML). 25858894 2015
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 Biomarker disease BEFREE The gene expression signature of AML blasts with oncogenic NRAS indeed corresponded to a more mature profile compared to blasts with wildtype RAS, as demonstrated by gene set enrichment analysis (GSEA) and real-time PCR analysis of myeloid ecotropic viral integration site 1 homolog (MEIS1) in a unique cohort of AML patients. 25901794 2015
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease BEFREE Oncogenic NRAS mutations are highly prevalent in acute myeloid leukemia (AML). 25361812 2014
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease BEFREE Here we describe the clinical application of MiSeq, a next-generation sequencing platform to screen mutational hotspots in 54 cancer-related genes including genes relevant in acute myeloid leukemia (NRAS, KRAS, FLT3, NPM1, DNMT3A, IDH1/2, JAK2, KIT and EZH2). 24142997 2014
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease BEFREE We screened 45 patients with chronic myelomonocytic leukemia (n = 39 patients, including seven with transformed-acute myeloid leukemia), MDS/MPN unclassifiable (n = 5), and atypical BCR-ABL1-negative CML (n = 1) for mutations in ASXL1, CBL, NRAS, and TET2 genes by molecular genetics including a sensitive next-generation sequencing (NGS) technique. 24164563 2014
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease BEFREE To elucidate the downstream functions of activated NRAS in AML, we used a murine model that harbors Mll-AF9 and a tetracycline-repressible, activated NRAS (NRAS(G12V)). 25316678 2014
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease BEFREE As activation of Evi1 has been shown to coincide with NRAS mutations in human acute myeloid leukemia, our murine model recapitulates crucial events in human leukemogenesis. 22847614 2013
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease BEFREE We have previously demonstrated that two prognostic features of myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML), mutant NRAS and over-expressing BCL-2, cooperate physically and functionally in vivo. 23153525 2013
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.700 GeneticVariation disease CLINVAR RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse: a study of the Japanese Childhood AML Cooperative Study Group. 22407852 2012