Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.060 Biomarker disease BEFREE Several recent studies indicate that the p53 tumor suppressor pathway is often inactivated in de novo myeloid leukemia through oncogenic-specific mechanisms, which converge on aberrant p53 protein deacetylation. 26923266 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.060 Biomarker disease BEFREE Thus, overexpression of sPRDM16 induces abnormal growth of stem cells and progenitors and cooperates with disruption of the p53 pathway in the induction of myeloid leukemia. 18037989 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.060 AlteredExpression disease LHGDN 5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia. 15609309 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.060 GeneticVariation disease BEFREE The activations of the ras oncogenes or inactivation of the p53 anti-oncogene by point mutations have been described recently in several cases of MDS as well as AML, suggesting a critical role for these alterations in the development of these myelogenous leukemias. 8580805 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.060 Biomarker disease BEFREE Conformational change of p53 protein in growth factor-stimulated human myelogenous leukemia cells. 7950913 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.060 Biomarker disease BEFREE Since p53 has been implicated in lymphatic and some myeloid leukemias, such as the blastic phase of chronic myelogenous leukemia, we sought to address the role of p53 gene mutations within exons 4-9 in myelodysplastic syndromes (MDS), a myeloid preleukemic condition. 8241345 1993