Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.350 Biomarker disease BEFREE Based on these results, the 5-LO inhibitor zileuton has been introduced in clinical trials as a therapeutic option to target the LSC although its effect on primary human CML LSC has not been studied. 28623130 2017
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.350 AlteredExpression disease BEFREE Low leukotriene B4 receptor 1 leads to ALOX5 downregulation at diagnosis of chronic myeloid leukemia. 25193960 2014
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.350 Biomarker disease BEFREE We have shown that Alox5 is a critical regulator of leukemia stem cells (LSCs) in a BCR-ABL-induced chronic myeloid leukemia (CML) mouse model, and we hypothesize that the Alox5 pathway represents a major molecular network that regulates LSC function. 21596859 2011
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.350 Biomarker disease BEFREE Targeting of these key BCR-ABL downstream genes provides an opportunity to eradicate LSCs, as shown in our work that identifies the Alox5 gene as a key regulator of the function of CML LSCs. 20470758 2010
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.350 Therapeutic disease CTD_human Treatment of CML mice with a 5-LO inhibitor also impaired the function of LSCs similarly by affecting LT-LSCs, and prolonged survival. 19503090 2009
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.350 Biomarker disease BEFREE We believe that our discovery of the role of Alox5 in regulating the function of LSCs in CML reminds us of viewing CSCs at a different angel. 19823023 2009
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.350 Therapeutic disease CTD_human We believe that our discovery of the role of Alox5 in regulating the function of LSCs in CML reminds us of viewing CSCs at a different angel. 19823023 2009