Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3
0.400 AlteredExpression disease BEFREE The putative targets: PROTEINASE 3, SURVIVIN, and hTERT were expressed only at relatively low levels by the CD34(+)CD38(-)ALDH(high) CML cells, similar to the normal CD34(+)CD38(-)ALDH(high) cells and less than in the total CML CD34(+) cells. 21132730 2011
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3
0.400 Biomarker disease LHGDN PR1-CTL responses detected in 7 of 28 CML patients before transplantation were not predictive of outcome and correlated inversely with PR3 and ELA2 expression. 17412886 2007
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3
0.400 AlteredExpression disease BEFREE To investigate whether eradication of CML after allogeneic stem cell transplantation (SCT) was influenced by PR3 and ELA2 gene expression or PR1-specific CTL responses, we studied cells from 87 CML patients and 27 HLA-A*0201(+) donors collected prior to T-cell-depleted HLA-identical sibling SCT. 17412886 2007
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3
0.400 AlteredExpression disease BEFREE Other attractive targets are the Wilms' tumor 1 antigen and the PR1 epitope from proteinase 3, a granule protein overexpressed in CML. 20425356 2007
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3
0.400 Biomarker disease BEFREE In patients with CML in complete cytogenetic remission during IFN-alpha treatment, we detected some reactivity of CD8(+) T cells against BCR-ABL in IFN-gamma ELISPOT assays, which was weaker as compared with proteinase 3 (PR3)- or prame-directed responses, suggesting that the BCR-ABL protein is less immunogenic as compared with other CML-derived antigens. 16740729 2006
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3
0.400 AlteredExpression disease BEFREE Molecular profiling of CD34+ cells identifies low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML. 16144796 2006
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3
0.400 Biomarker disease CTD_human Chronic myeloid leukemia cells express tumor-associated antigens eliciting specific CD8+ T-cell responses and are lacking costimulatory molecules. 17157168 2006
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3
0.400 Biomarker disease BEFREE In human leukocyte antigen A*0201(+) (HLA-A*0201(+)) individuals, response after interferon-alpha (IFN-alpha) was shown to be associated with the emergence of CML-specific cytotoxic T cells that recognize PR-1, a myeloblastin (MBN)-derived nonapeptide. 12393722 2003
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3
0.400 Biomarker disease BEFREE We have shown that cytotoxic T lymphocytes specific for PR1, an HLA-A2-restricted nonopeptide derived from proteinase 3, kill leukemia cells and may contribute to the elimination of chronic myelogenous leukemia (CML) after treatment with IFN or allogeneic bone marrow transplant. 12618518 2003
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3
0.400 AlteredExpression disease LHGDN Together, the induction of MBN expression by IFN-alpha, but not imatinib, may contribute to the specific ability of IFN-alpha to induce an MBN-specific T-cell response in CML patients. 12393722 2003
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3
0.400 Biomarker disease BEFREE Using HLA-A2-PR1 tetramer analysis, we found that the frequency of T cells recognizing the PR1 epitope of proteinase 3 was not significantly different in allodepleted and unmanipulated PBMCs from patients with chronic myeloid leukemia (CML) undergoing transplantation. 12763937 2003
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3
0.400 Biomarker disease BEFREE These data support the possibility that T-cell responses to allelic differences of proteinase 3 could be used as a basis for designing leukemia-specific adoptive T-cell therapy in acute and chronic myeloid leukemias. 9924693 1999
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3
0.400 Biomarker disease BEFREE Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units. 9326217 1997