Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 GeneticVariation disease BEFREE Previously, we observed that transcription factor RUNX1 mutations (RUNX1-MT) coexisted with ASXL1-MT in CMML and at myeloid blast phase of chronic myeloid leukemia. 31640815 2019
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 Biomarker disease BEFREE The overall findings suggest the roles of altered functions of AML1 imposed by some, but not all, mutants, and the elevated expression of wt.AML1 for the disease progression of CML. 24098673 2013
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 Biomarker disease BEFREE These results suggest that RUNX1 abnormalities may promote acute myeloid leukemic transformation in a subset of CML patients. 22318203 2012
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 Biomarker disease ORPHANET These results suggest that RUNX1 abnormalities may promote acute myeloid leukemic transformation in a subset of CML patients. 22318203 2012
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 Biomarker disease BEFREE Development of t(8;21) and RUNX1-RUNX1T1 in the Philadelphia-positive clone of a patient with chronic myelogenous leukemia: additional evidence for multiple steps involved in disease progression. 21504717 2011
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 GeneticVariation disease BEFREE RUNX1-EVI1 is a chimeric gene generated by t(3;21)(q26;q22) observed in patients with aggressive transformation of myelodysplastic syndrome or chronic myelogenous leukemia. 19016745 2008
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 GeneticVariation disease BEFREE The coexistence of BCR-ABL and t(3;21)(q26;q22) with RUNX1 rearrangement might play a pivotal role in the CML blast transformation. 18068536 2008
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 GeneticVariation disease BEFREE Cryptic and partial deletions of PRDM16 and RUNX1 without t(1;21)(p36;q22) and/or RUNX1-PRDM16 fusion in a case of progressive chronic myeloid leukemia: a complex chromosomal rearrangement of underestimated frequency in disease progression? 18767145 2008
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 Biomarker disease BEFREE These events are associated with a short survival and support the concept of a cooperative effect of BCR-ABL with molecular RUNX1 abnormalities on the differentiation arrest phenotype observed during progression of CML and in BCR-ABL+ ALL. 18202228 2008
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 GeneticVariation disease BEFREE Recently, we reported that the fusion protein AML1/MDS1/EVI1 (AME), a product of a t(3;21)(q26;q22) associated with chronic myelogenous leukemia and acute myelogenous leukemia, displays a complex pattern of self-interaction. 17575132 2007
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 GeneticVariation disease BEFREE We compared the incidence of submicroscopic deletions accompanying balanced translocations using interphase fluorescence in situ hybridization (FISH) in 245 patients with chronic myeloid leukemia (CML), 79 patients with acute lymphoblastic leukemia (ALL) and BCR-ABL (n=70) or MLL rearrangements (n=29), and 412 patients with acute myeloid leukemia (AML) with CBFB-MYH11 (n=122), PML-RARalpha (n=108), AML1-ETO (n=112), or MLL rearrangements (n=98). 15820957 2005
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 AlteredExpression disease BEFREE In contrast, EVI-1 is barely expressed in normal hematopoietic cells, but it is overexpressed in chronic myelocytic leukemia in blastic crisis and myelodysplastic syndrome-derived leukemia. 15156182 2004
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 Biomarker disease LHGDN Two clonal occurrences of tetrasomy 21 in an atypical chronic myeloid leukemia with wild-type RUNX1 alleles. Additional support for a gene dosage effect of chromosome 21 or RUNX1 in leukemia. 15339695 2004
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 Biomarker disease BEFREE AML1/Evi-1 is a chimeric protein that is derived from t(3;21), found in blastic transformation of chronic myelogenous leukemia. 11965542 2002
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 GeneticVariation disease BEFREE In KG1 cells, the AML1-ETO hybrid gene [associated with the t(8;21) translocation of acute myeloid leukemia] occurred significantly more often than the BCR-ABL [associated with t(9;22) chronic myeloid leukemia] or the DEK-CAN [associated with t(6;9) acute myeloid leukemia] fusion genes. 9458083 1998
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 GeneticVariation disease BEFREE The t(3;21)(q26;q22) chromosomal translocation associated with blastic crisis of chronic myelogenous leukemia results in the formation of the AML1/Evi-1 chimeric protein, which is thought to play a causative role in leukemic transformation of hematopoietic cells. 9834202 1998
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 GeneticVariation disease BEFREE Activation of the Evi-1 gene was first described to be associated with the transformation of murine myeloid leukaemias and has previously been detected in cases of human acute myeloid leukaemia (AML) and chronic myeloid leukaemia (CML) in blast crises and in myelodysplastic syndromes. 9432037 1997
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 GeneticVariation disease BEFREE We examined 42 adult patients with B-cell lineage ALL and 13 adult patients with lymphoblastic transformation of chronic myeloid leukemia (CML) to detect TEL/AML1 fusion genes using the reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blotting, but no translocation was detected. 9277052 1997
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 GeneticVariation disease BEFREE The chromosome region 21q22, where AML1 maps, is involved in several other karyotypic aberrations, such as the t(3;21) translocation associated with a subset of therapy-related myelodysplastic syndromes and AML, and the blast phase of chronic myelogenous leukemia. 9234595 1997
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 Biomarker disease BEFREE The AML1/EVI-1 could play an important role in leukemic progression of chronic myelocytic leukemia by these dual functions as a transcription factor. 9209439 1997
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 GeneticVariation disease BEFREE Twenty-nine such cell lines established from children (n = 13) or adults (n = 13) with early B-lineage ALL and five cell lines derived from chronic myeloid leukemia in blast crisis or B cell non-Hodgkin's lymphoma were investigated for the occurrence of the TEL-AML1 rearrangement by RT-PCR. 9067587 1997
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 GeneticVariation disease BEFREE We have used RT-PCR, followed by Southern blotting and direct sequencing, to establish the incidence of TEL-AML1 rearrangement in 131 adults with acute leukaemia (101 with ALL and 30 with chronic myeloid leukaemia in blastic crisis). 8982044 1996
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 AlteredExpression disease BEFREE Increased Evi-1 expression is frequently observed in blastic crisis of chronic myelocytic leukemia. 8656673 1996
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 GeneticVariation disease BEFREE We isolated the AML1/EVI-1 fusion gene generated by the t(3;21) translocation, which is usually found in blastic crisis of chronic myelocytic leukemia. 8867720 1996
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.400 Biomarker disease BEFREE Here we report the consistent identification of fusion transcripts between AML1 and EAP or between AML1 and previously unidentified sequences that we named MDS1 (MDS-associated sequences) in the leukemic cells of four patients with therapy-related myelodysplasia/acute myeloid leukemia and in one patient with chronic myelogenous leukemia in blast crisis, all of whom had a t(3;21). 8171026 1994