Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6427
Gene Symbol: SRSF2
SRSF2
0.200 Biomarker disease BEFREE This meta-analysis suggests that SRSF2 has a poor prognosis in patients with MDS, but no prognosis impact on patients with CMML. 29757120 2018
Entrez Id: 6427
Gene Symbol: SRSF2
SRSF2
0.200 Biomarker disease BEFREE RNA-seq analyses of telomere dysfunctional CMP identified aberrantly spliced transcripts linked to pathways relevant to MDS pathogenesis such as genome stability, DNA repair, chromatin remodeling, and histone modification, which are also enriched in mouse CMP haploinsufficient for SRSF2 and in CD34(+) CMML patient cells harboring SRSF2 mutation. 25965571 2015
Entrez Id: 6427
Gene Symbol: SRSF2
SRSF2
0.200 GeneticVariation disease BEFREE Here, we review recent biologic observations that support the current CMML WHO classification, such as the high frequency of SRSF2 and ASXL1 mutations compared with MDS and critical dependence of CMML cells on granulocyte-macrophage colony-stimulating factor signaling. 25575034 2015
Entrez Id: 6427
Gene Symbol: SRSF2
SRSF2
0.200 GeneticVariation disease BEFREE SRSF2 mutations are frequent in chronic myelomonocytic leukemia patients, but show a relatively lower incidence in Chinese patients. 25533824 2014
Entrez Id: 6427
Gene Symbol: SRSF2
SRSF2
0.200 GeneticVariation disease BEFREE SRSF2 mutations were identified in 16 (44%) of 36 CMMLs, including 1 of 3 cases with associated systemic mastocytosis, 4 (20%) of 20 Ph- MPN, and 1 (4.5%) of 22 MDS. 25305095 2014
Entrez Id: 6427
Gene Symbol: SRSF2
SRSF2
0.200 Biomarker disease BEFREE We conclude that SRSF2 is the most frequently mutated spliceosome gene in CMML but neither it nor SF3B1 or U2AF35 mutations are prognostically relevant. 23335386 2013
Entrez Id: 6427
Gene Symbol: SRSF2
SRSF2
0.200 GeneticVariation disease BEFREE We investigated the contribution of U2AF1, SRSF2 and SF3B1 mutations in the pathogenesis of chronic myelomonocytic leukemia and closely related diseases. 22773603 2013
Entrez Id: 6427
Gene Symbol: SRSF2
SRSF2
0.200 Biomarker disease BEFREE Among spliceosome component mutations, those involving SF3B1 are most frequent in myelodysplastic syndromes with ring sideroblasts (MDS-RS; ∼ 75% incidence) and SRSF2 in chronic myelomonocytic leukemia (∼ 28% incidence). 22968464 2012
Entrez Id: 6427
Gene Symbol: SRSF2
SRSF2
0.200 GeneticVariation disease BEFREE Most recently, several spliceosome-associated-gene mutations were reported and SRSF2 mutations are frequently detected in CMML. 22289493 2012
Entrez Id: 6427
Gene Symbol: SRSF2
SRSF2
0.200 Biomarker disease BEFREE In conclusion, these data show the importance of SRSF2mut as new diagnostic marker in CMML. 22919025 2012
Entrez Id: 6427
Gene Symbol: SRSF2
SRSF2
0.200 Biomarker disease HPO