Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | disease | BEFREE | Previously, we observed that transcription factor RUNX1 mutations (RUNX1-MT) coexisted with ASXL1-MT in CMML and at myeloid blast phase of chronic myeloid leukemia. | 31640815 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Our results stress the need for robust biomarkers of HMA activity in CMML and for novel treatment strategies in patients with myeloproliferative features and RUNX1 mutations. | 29728305 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Somatic cell mutations and chromosomal abnormalities, including those of RUNX1, are observed in myelodysplastic syndrome, acute myeloid leukemia, acute lymphoblastic leukemia, and chronic myelomonocytic leukemia at a high frequency. | 29883054 | 2018 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Correlation of the activities of RUNX1 mutants with the clinical outcomes revealed that patients harboring lower activities of RUNX1 mutants had a higher risk and shorter time to secondary acute myeloid leukemia transformation in MDS and CMML. | 25840971 | 2015 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Here we demonstrate that runx1 deletion in mice induces the persistence of MYH10 in platelets, and a similar persistence was observed in platelets of patients with constitutional (familial platelet disorder/acute myeloid leukemia) or acquired (chronic myelomonocytic leukemia) RUNX1 mutations. | 22677128 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | This finding suggests that alterations of the CBL gene and RUNX1 gene may cooperate in the pathogenesis of CMML in patients with FPD/AML. | 22138511 | 2012 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | We examined RUNX1 mutations in 81 patients with CMML at initial diagnosis. | 19282830 | 2009 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes. | 18925961 | 2008 |