Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.080 GeneticVariation disease BEFREE Previously, we observed that transcription factor RUNX1 mutations (RUNX1-MT) coexisted with ASXL1-MT in CMML and at myeloid blast phase of chronic myeloid leukemia. 31640815 2019
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.080 Biomarker disease BEFREE Our results stress the need for robust biomarkers of HMA activity in CMML and for novel treatment strategies in patients with myeloproliferative features and RUNX1 mutations. 29728305 2018
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.080 Biomarker disease BEFREE Somatic cell mutations and chromosomal abnormalities, including those of RUNX1, are observed in myelodysplastic syndrome, acute myeloid leukemia, acute lymphoblastic leukemia, and chronic myelomonocytic leukemia at a high frequency. 29883054 2018
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.080 GeneticVariation disease BEFREE Correlation of the activities of RUNX1 mutants with the clinical outcomes revealed that patients harboring lower activities of RUNX1 mutants had a higher risk and shorter time to secondary acute myeloid leukemia transformation in MDS and CMML. 25840971 2015
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.080 GeneticVariation disease BEFREE Here we demonstrate that runx1 deletion in mice induces the persistence of MYH10 in platelets, and a similar persistence was observed in platelets of patients with constitutional (familial platelet disorder/acute myeloid leukemia) or acquired (chronic myelomonocytic leukemia) RUNX1 mutations. 22677128 2012
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.080 Biomarker disease BEFREE This finding suggests that alterations of the CBL gene and RUNX1 gene may cooperate in the pathogenesis of CMML in patients with FPD/AML. 22138511 2012
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.080 GeneticVariation disease BEFREE We examined RUNX1 mutations in 81 patients with CMML at initial diagnosis. 19282830 2009
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
0.080 GeneticVariation disease BEFREE Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes. 18925961 2008