Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE T-LGLL and ATL share dependence on IL-2 and IL-15 for survival and both diseases lack effective therapies. 30353031 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 GeneticVariation disease BEFREE Transforming activity was further demonstrated by the ability of the FBXW7 D510E mutant to provide IL-2-independent growth of Tax-immortalized human T cells and increase the tumor formation in a xenograft mouse model of ATL. 27247421 2016
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia. 26396258 2015
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE These signaling proteins represent novel and promising molecular therapeutic targets for IL-2-dependent ATL. 22402124 2012
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 AlteredExpression disease BEFREE Abnormal IL-2Rα chain expression and the IL-2 dependency of ATL cell lines greatly contributed to the study of leukemogenesis of ATL. 22068231 2011
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE In this study, we demonstrated that withdrawal of interleukin (IL)-2 from IL-2-dependent ATL cell lines resulted in induction of HTLV-1 mRNA and protein expression, and that viral induction was associated with phosphorylation of the stress kinase p38 and its downstream CREB. 17950728 2007
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 AlteredExpression disease BEFREE HTLV-I transformed T-cell lines and fresh ATL cells are characterized by constitutive activation of the interleukin-2 receptor (IL-2R) signaling pathway however, the mechanism(s) responsible for constitutive IL-2R activation are unknown. 14630083 2004
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE Here, we report that IL-2-dependent ATL cell lines also express IL-4Ralpha and respond to IL-4, which was verified by the activation of cytoplasmic transcriptional activator Stat6 protein. 12225394 2002
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE Exposure to 10(-6) to 10(-10) M bexarotene or Panretin for 48 hours was associated with increased expression of both the p55 and p75 subunits of the IL-2R in T-cell leukemias and p75 in B-cell leukemias. 12149223 2002
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE Alteration of p16 (CDKN2) gene is associated with interleukin-2-induced tumor cell growth in adult T-cell leukemia. 10378889 1999
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE High rate of chromosomal abnormalities in HTLV-I-infected T-cell colonies derived from prodromal phase of adult T-cell leukemia: a study of IL-2-stimulated colony formation in methylcellulose. 9973953 1999
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE Human thioredoxin (hTRX)/adult T-cell leukemia (ATL)-derived factor (ADF) was originally reported as an interleukin-2 (IL-2) receptor-alpha-inducing factor produced by human T-cell lymphotropic virus-1-positive (HTLV-1+) cell lines. 11228744 1999
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE Analysis of RNA from HTLV-I-infected cells established from patients with adult T cell leukemia (ATL) as well as tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM) and both IL-2-dependent and IL-2-independent HTLV-I-infected cell lines by RNase protection has confirmed the existence of all of the alternatively spliced messages in each cell line analyzed. 9177442 1997
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 AlteredExpression disease BEFREE Adult T cell leukemia (ATL) is an aggressive malignancy that is associated with HTLV-I infection and characterized by constitutive expression of the high-affinity interleukin-2 receptor. 9356333 1997
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE A long-term T-cell line, termed SP+, was developed from a human T-cell leukemia virus type I (HTLV-I)-infected patient with adult T-cell leukemia that is dependent on exogenous IL-2 for growth. 7564472 1995
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 AlteredExpression disease BEFREE The immunological abnormality of T lymphocytes in patients with adult T cell leukemia (ATL) is characterized by the abnormal enhanced expression of the 55 kDa chain of the receptor for interleukin 2 (IL-2R/p55) (Tac), and down-regulation of CD3 antigen. 8049647 1994
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE We describe a 50-year-old man with adult T-cell leukemia complicated by laryngeal tuberculosis whose tumor cells proliferate in response to IL-2 in a paracrine manner. 8092127 1994
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 AlteredExpression disease BEFREE Leukemia cells from ATL patients generally expressed low levels of GD2 but the percentage of GD2+ cells increased up to 40-70% after in vitro culture in the presence of interleukin 2 for about a week. 8095337 1993
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE Interleukin-2 increases production and secretion of parathyroid hormone-related peptide by human T cell leukemia virus type I-infected T cells: possible role in hypercalcemia associated with adult T cell leukemia. 8099324 1993
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE A novel interleukin-2 (IL-2)-dependent T-cell line, WHN2, was established from a patient with adult T-cell leukemia (ATL) not associated with human T-cell leukemia virus type I (HTLV-I). 8390425 1993
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia. 8400227 1993
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE Interleukin-2 production by primary adult T cell leukemia tumor cells is macrophage dependent. 1288288 1992
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE Phenotypic changes induced by interleukin-2 (IL-2) and IL-3 in an immature T-lymphocytic leukemia are associated with regulated expression of IL-2 receptor beta chain and of protein tyrosine kinases LCK and LYN. 1379847 1992
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE Adult T-cell leukemia (ATL) cells have been shown to express the receptor for IL-2 by studies using anti-CD25 monoclonal antibody, but these cells usually show no or only a weak proliferative response to IL-2. 1861543 1991
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.100 Biomarker disease BEFREE The transforming activity of tax, possibly via a transcriptional deregulation of cell growth control, may play an important role in leukemogenesis of ATL in addition to its aberrant stimulation of the interleukin 2 system. 2300570 1990