Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE T-Cell Leukemia/Lymphoma 1 (TCL1): An Oncogene Regulating Multiple Signaling Pathways. 30151355 2018
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 GeneticVariation disease BEFREE Finally, we observed a fludarabine potentiation by SCH900776 in a T-cell leukemia 1 (TCL1)-driven mouse model of CLL. 27556692 2016
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE Chronic lymphocytic leukemia (CLL) is the most common human leukemia, and transgenic mouse studies indicate that activation of the T-cell leukemia/lymphoma 1 (TCL1) oncogene is a contributing event in the pathogenesis of the aggressive form of this disease. 27071132 2016
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE T-cell leukemia/lymphoma protein 1 (TCL1) is expressed by several B-cell lymphomas, including MCL. 25688912 2015
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 GeneticVariation disease BEFREE The pro-survival oncogene T-cell leukemia 1 (TCL1) is causally linked to the high threshold towards classical apoptosis in CLL. 26041471 2015
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE B-cell chronic lymphocytic leukemia (CLL) is the most common human leukemia and dysregulation of the T-cell leukemia/lymphoma 1 (TCL1) oncogene is a contributing event in the pathogenesis of the aggressive form of this disease based on transgenic mouse studies. 25646413 2015
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE Because immune-precipitation and mass spectrometry studies revealed that ROR1 could complex with T-cell leukemia 1 (TCL1) in CLL, we crossed these animals with Eµ-TCL1-Tg (TCL1) mice. 24379361 2014
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE In this study, we assessed the protein levels of AID splice isoforms by introducing an AID splice reporter construct into cell lines and primary CLL cells from patients as well as from WT and TCL1(tg) C57BL/6 mice (where TCL1 is T-cell leukemia/lymphoma 1). 24668151 2014
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE T-cell leukemia/lymphoma 1 (TCL1) is an oncogene overexpressed in T-cell prolymphocytic leukemia and in B-cell malignancies including B-cell chronic lymphocytic leukemia and lymphomas. 23160471 2013
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 GeneticVariation disease BEFREE The 14q32.13 breakpoints were mapped by fluorescence in situ hybridization (FISH) in the region harboring the TCL1A/TCL1B/TCL6 genes, known to be affected by TCRA/D-mediated t(14;14)(q11;q32)/inv(14)(q11q32) occurring in T-cell leukemia/lymphoma. 22553924 2012
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE The T-cell leukemia/lymphoma 1 (TCL1) oncogene is a target of chromosomal translocations and inversions at 14q31.2, and its rearrangement in T cells causes T-cell prolymphocytic leukemias. 22065599 2012
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE Here, we determined whether T-cell leukemia/lymphoma 1 (TCL1) oncoprotein encoded by the TCL1 gene could be a target for immunotherapy of B-cell malignancies. 22645177 2012
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 GeneticVariation disease BEFREE In a recent genome-wide association study, we identified SNPs - including one that created an estrogen response element near the 3' end of the T-cell leukemia 1A (TCL1A) gene - that were associated with musculoskeletal pain in women on adjuvant AI therapy for breast cancer. 22405131 2012
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 GeneticVariation disease BEFREE T cell leukemia 1a (TCL1a) (14q32.1) may be implicated in this case. 21505955 2011
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 GeneticVariation disease BEFREE T-cell leukemia 1A (TCL1A) was the gene closest (926-7000 bp) to the four SNPs. 20876420 2010
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE We investigated the role of Akt and its modulation by the protooncogene T-cell leukemia 1a (Tcl1a) in the survival pathways of primary CLL samples and CLL-derived prolymphocytic cell lines MEC-1 and MEC-2. 20823161 2010
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE Deregulation of the T-cell leukemia/lymphoma 1 (TCL1) oncogene in mouse B cells causes a CD5-positive leukemia similar to aggressive human B-CLLs. 20357824 2010
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE T-cell leukemia/lymphoma protein 1 (TCL1) was recently shown to display an expression pattern in chronic lymphocytic leukemia (CLL) corresponding to molecular subtypes, where poor-risk patients demonstrated higher expression levels. 19889012 2010
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE TCL1 transgenic mice (TCL1-tg), in which TCL1 is ectopically expressed in mature lymphocytes, develop multiple B- and T-cell leukemia and lymphoma subtypes, supporting an oncogenic role for TCL1 that probably involves AKT and MAPK-ERK signaling pathway augmentation. 19147787 2009
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE Deregulation of the T cell leukemia/lymphoma 1 (TCL1) oncogene in mouse B cells causes a CD5-positive leukemia similar to aggressive human B-CLLs. 19064921 2008
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 GeneticVariation disease BEFREE The T-cell leukemia 1 (TCL1) oncoprotein is overexpressed by chromosomal rearrangement in the majority of cases of T-cell prolymphocytic leukemia (T-PLL). 17890451 2008
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 GeneticVariation disease BEFREE Recently, unique gene expression profiles differentiating BL and DLBCL were reported and include higher transcript levels of T-cell leukemia-1 (TCL1) and CD38 and lower transcript levels of CD44 in MYC+ BL relative to MYC- DLBCL. 18162778 2008
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 GeneticVariation disease BEFREE All expressed T-cell leukemia 1 (TCL-1) and CD7; cutaneous lymphocyte antigen expression was discernible in a dot-like perinuclear array. 16908353 2006
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 Biomarker disease BEFREE Pair-wise comparisons suggested that some genes (zinc finger protein 350 [ZNF350], solute carrier family 1, member 6 [SLC1A6], F-box protein 7 [FBX07] and vacuole 14 protein homolog [VAC14]) distinguished most classes of fatigued subjects from healthy subjects, whereas others (patched homolog 2 [PTCH2] and T-cell leukemia/lymphoma [TCL1A]) differentiated specific fatigue classes. 16610948 2006
Entrez Id: 8115
Gene Symbol: TCL1A
TCL1A
0.100 AlteredExpression disease BEFREE Elevated T-cell leukemia-1 (TCL1) oncoprotein expression might promote human Burkitt lymphoma (BL) because increased TCL1 causes Burkitt-like lymphomas in TCL1 transgenic mice. 16146820 2005