Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.570 GeneticVariation disease BEFREE Polymorphism in the Promoter Region of NFE2L2 Gene Is a Genetic Marker of Susceptibility to Cirrhosis Associated with Alcohol Abuse. 31340446 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.570 Biomarker disease BEFREE Therefore, in the present work, the capacity of doxazosin (<i>α</i>1 antagonist), carvedilol (nonselective beta-adrenoceptor blocker with alpha 1-blocking properties), and curcumin (antioxidant and anti-inflammatory compound) to reverse liver cirrhosis and studying the possible modulation of Nrf-2 and NF-<i>κ</i>B were evaluated. 31183386 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.570 Biomarker disease BEFREE Integrated stress response in hepatitis C promotes Nrf2-related chaperone-mediated autophagy: A novel mechanism for host-microbe survival and HCC development in liver cirrhosis. 31386899 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.570 Biomarker disease BEFREE Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis. 29852187 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.570 AlteredExpression disease BEFREE PBC was associated with reduced Nrf2 expression and autophagy deterioration and these impairments were more advanced in patients with cirrhosis. 28333129 2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.570 Biomarker disease BEFREE Finally, we showed the therapeutic importance of targeting Hrd1, rather than Keap1, to prevent Nrf2 loss and suppress liver cirrhosis. 24636985 2014
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.570 Therapeutic disease CTD_human Nuclear erythroid 2-related factor 2: a novel potential therapeutic target for liver fibrosis. 23793039 2013
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.570 AlteredExpression disease BEFREE It remains to be established in further studies if the observed decrease of Nrf2 expression is just a result of liver cirrhosis or is primary, playing a role in disease pathogenesis. 22459801 2012
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.570 Therapeutic disease RGD Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats. 22732220 2012
Entrez Id: 183
Gene Symbol: AGT
AGT
0.560 Biomarker disease BEFREE The aim was to estimate the natriuretic and neurohumoral effects of an ANGII receptor antagonist (losartan) in the late phase of the disease in a rat model of liver cirrhosis. 30231858 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.560 Biomarker disease BEFREE An impaired contractile response to the angiotensin II peptide of the classical RAS system has been described in animal models of cirrhosis and in vivo in cirrhotic subjects. 30179652 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.560 Biomarker disease RGD Expression of angiotensinogen during hepatic fibrogenesis and its effect on hepatic stellate cells. 21873937 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.560 GeneticVariation disease LHGDN Fibrogenic polymorphisms (TGF-beta, PAI-1, AT) in Mexican patients with established liver fibrosis. Potential correlation with pirfenidone treatment. 18797412 2008
Entrez Id: 183
Gene Symbol: AGT
AGT
0.560 GeneticVariation disease LHGDN Polymorphisms of the core promoter region of the AGT gene (AGT-20 and AGT-6) were associated with liver cirrhosis in patients with chronic hepatitis B. 16911698 2006
Entrez Id: 183
Gene Symbol: AGT
AGT
0.560 GeneticVariation disease BEFREE Polymorphisms of the core promoter region of the AGT gene (AGT-20 and AGT-6) were associated with liver cirrhosis in patients with chronic hepatitis B. 16911698 2006
Entrez Id: 183
Gene Symbol: AGT
AGT
0.560 Biomarker disease CTD_human Inhibition of cGMP-specific phosphodiesterase type 5 reduces sodium excretion and arterial blood pressure in patients with NaCl retention and ascites. 15613622 2005
Entrez Id: 183
Gene Symbol: AGT
AGT
0.560 GeneticVariation disease BEFREE We evaluated the relationship between genetic polymorphisms of the renin-angiotensin system (A1166C angiotensin II type 1 receptor (AT1R), angiotensinogen T174M and M235T, and angiotensin-converting enzyme I/D) and the effects of losartan on portal and systemic hemodynamic in patients with cirrhosis and portal hypertension. 15743363 2005
Entrez Id: 183
Gene Symbol: AGT
AGT
0.560 GeneticVariation disease BEFREE In this respect, we investigated the impact of functional genetic polymorphisms of TGF-beta1 (codon 10 Leu/Pro, codon 25 Arg/Pro), TNF-alpha (-308 G/A, -238 G/A) and angiotensinogen (-6 G/A) on the development of cirrhosis in HHC. 15941661 2005
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.510 Biomarker disease BEFREE Outcome variables were: a) liver fibrosis (Metavir score) [fibrosis stage (F0, F1, F2, F3 and F4) and advanced fibrosis and cirrhosis (F ≥ 3 and F4, respectively)]; b) non-invasive indexes [FIB-4, APRI, and their cut-offs (FIB-4 ≥ 3.25 and APRI≥1.5)]; c) inflammation-related biomarkers (leptin, HGF, NGF, sFasL, sFas, MIF, HA, Ang-2, TIMP1, MMP1 and MMP2). 30336268 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.510 Biomarker disease CTD_human Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis. 26396155 2016
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.510 Therapeutic disease RGD Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats. 23411180 2013
Entrez Id: 2321
Gene Symbol: FLT1
FLT1
0.510 Biomarker disease BEFREE PGF and VEGFR1 may have an important role in the pathogenesis of the neovascular response in cirrhosis. 17696935 2007
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.510 Biomarker disease CTD_human Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. 15763341 2005
Entrez Id: 2321
Gene Symbol: FLT1
FLT1
0.510 Biomarker disease CTD_human Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. 11981751 2002
Entrez Id: 2321
Gene Symbol: FLT1
FLT1
0.510 Biomarker disease RGD Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. 11981751 2002