Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.370 | AlteredExpression | group | BEFREE | Manipulation of levels of GSH and Nrf2 in HepG2 cells confirmed that both molecules mediate the protective effects of SFN against H<sub>2</sub>O<sub>2</sub>. | 30940595 | 2019 | ||||
|
0.370 | Biomarker | group | BEFREE | In human hepatoma HepG2 cells, electrophoretic mobility shift assay (EMSA) was used to determine the affinity of nuclear factor-E2-related factor (Nrf2) binding to MRP4 promoter. | 31637886 | 2019 | ||||
|
0.370 | AlteredExpression | group | BEFREE | PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway. | 30619751 | 2018 | ||||
|
0.370 | Biomarker | group | BEFREE | Overactivated Nrf2 was required for hepatoma growth in DEN-induced HCC. | 28655791 | 2017 | ||||
|
0.370 | Biomarker | group | BEFREE | Taken together, these data indicate that β-catenin creates a protumorigenic hepatic environment in part by indirectly activating Nrf2 and implicate oxidative stress as a possible driving force for a subset of β-catenin-driven liver tumors in children. | 27734029 | 2016 | ||||
|
0.370 | Biomarker | group | CTD_human | Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth. | 20722399 | 2010 | ||||
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0.370 | AlteredExpression | group | BEFREE | Low dose (7.5 J/m(2)) UVB exposure of mouse hepatoma, mouse keratinocyte, and human skin fibroblast cells led to the nuclear accumulation of Nrf2 and up-regulation of ARE-mediated gene expression. | 16951152 | 2006 | ||||
|
0.370 | Biomarker | group | BEFREE | In the present study, we investigated the transcriptional levels of NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO1) genes, the reporter activity mediated by antioxidant response element (ARE), and the protein level of transcription factor nuclear factor E2-related factor 2 (Nrf2), after administration of three major garlic OSCs--diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS)--in human hepatoma HepG2 cells. | 15477009 | 2004 |