Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.370 AlteredExpression group BEFREE Manipulation of levels of GSH and Nrf2 in HepG2 cells confirmed that both molecules mediate the protective effects of SFN against H<sub>2</sub>O<sub>2</sub>. 30940595 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.370 Biomarker group BEFREE In human hepatoma HepG2 cells, electrophoretic mobility shift assay (EMSA) was used to determine the affinity of nuclear factor-E2-related factor (Nrf2) binding to MRP4 promoter. 31637886 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.370 AlteredExpression group BEFREE PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway. 30619751 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.370 Biomarker group BEFREE Overactivated Nrf2 was required for hepatoma growth in DEN-induced HCC. 28655791 2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.370 Biomarker group BEFREE Taken together, these data indicate that β-catenin creates a protumorigenic hepatic environment in part by indirectly activating Nrf2 and implicate oxidative stress as a possible driving force for a subset of β-catenin-driven liver tumors in children. 27734029 2016
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.370 Biomarker group CTD_human Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth. 20722399 2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.370 AlteredExpression group BEFREE Low dose (7.5 J/m(2)) UVB exposure of mouse hepatoma, mouse keratinocyte, and human skin fibroblast cells led to the nuclear accumulation of Nrf2 and up-regulation of ARE-mediated gene expression. 16951152 2006
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.370 Biomarker group BEFREE In the present study, we investigated the transcriptional levels of NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO1) genes, the reporter activity mediated by antioxidant response element (ARE), and the protein level of transcription factor nuclear factor E2-related factor 2 (Nrf2), after administration of three major garlic OSCs--diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS)--in human hepatoma HepG2 cells. 15477009 2004