Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.360 AlteredExpression group BEFREE Protein expression in hepatoma HepG2 cells stimulated by TGF-beta(1) was analyzed by western blotting and plasminogen activator inhibitor type 1 (PAI-1) transcriptional activity in HepG2 cells was evaluated. 19793165 2010
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.360 Biomarker group CTD_human Loss of metallothionein predisposes mice to diethylnitrosamine-induced hepatocarcinogenesis by activating NF-kappaB target genes. 21159647 2010
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.360 AlteredExpression group BEFREE Cotransfection of human or rat PAI-1 promoter luciferase constructs with expression vectors for wild-type USF-2 or USF-2 mutants in human HepG2 and rat H4IIE cells as well as in primary rat hepatocytes revealed that the effects of USF on PAI-1 expression depend on the cell type rather than the promoter context and that the USF-specific region domain of USF accounts for the observed cell type-specific effects. 16330554 2006
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.360 Biomarker group BEFREE We have analyzed the regulation of PAI-1 mRNA accumulation by interleukin (IL)-1, IL-6, and dexamethasone, known mediators of the acute phase response, in HepG2 cells, a highly differentiated human hepatoma cell line that produces a broad spectrum of acute phase proteins including PAI-1. 8034668 1994
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.360 Biomarker group BEFREE The hepatoma cell line Hep G2 has been shown to synthesize PAI-1 in response to insulin. 8387542 1993
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.360 Biomarker group BEFREE Thus, these data clearly show that LRP is the major cell-surface receptor responsible for t-PA.PAI-1 complex binding and endocytosis on human hepatoma HepG2 cells and extend the multifunctional nature of LRP as an endocytosis receptor for several structurally and functionally distinct ligands. 8389767 1993
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.360 AlteredExpression group BEFREE In the current work we have analyzed the regulation of vitronectin by transforming growth factor-beta 1 (TGF beta 1) in this hepatoma cell line by Northern hybridization, polypeptide and immunoprecipitation analyses and compared the response to another TGF beta-regulated gene, plasminogen activator inhibitor (PAI-1). 1712727 1991