Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE TP53 mutations in metastatic liver tumors and corresponding primary tumors were identical in 96.9% (31/32), including some patients with heterogeneous primary tumor components. 30703342 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE The mRNA expression levels of PTEN and p53 in normal liver, tumor-adjacent and liver tumor samples were detected via RT-PCR. 28952211 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group RGD Effect of human umbilical cord blood derived CD34+ hematopoietic stem cell on the expression of Wnt4 and P53 genes in a rat model of hepatocellular carcinoma. 29429512 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Here we demonstrated that the utility of this approach resulted in macroscopic liver tumors as early as 4 months' post injection and most tumors harbored both p53 and Pten loss-of-function alterations. 28584302 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE However, we observed that SOCS1-deficient mice developed numerous and large liver tumor nodules following treatment with the hepatocarcinogen diethylnitrosamine (DEN) without showing increased interleukin-6 production or activation of p53. 26725321 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Therefore, we hypothesize that a recombinant NDV expressing P53 would be an ideal agent for the hepatoma therapy. 27465066 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE An inverse correlation existed between miR-1228 and p53 expression in hepatoma tissues compared with the adjacent tissues and three hepatoma cell lines. 25422913 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Tumorigenesis studies using an established liver tumor cell line confirmed a positive role of autophagy in tumorigenesis and a negative role of p53 in this process when autophagy was impaired. 25526090 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE In addition, α-PA up-regulated nuclear p53 and down-regulated cytoplasmic p53 expression in J5 cells. 25649747 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways. 25426556 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE Knockdown of WWP1 inhibits growth and induces apoptosis in hepatoma carcinoma cells through the activation of caspase3 and p53. 24792179 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE This compound binds to and abolishes the p53 protein, producing a genomic instability that promotes both the neoplastic progression and the hepatoma reprogramming. 23287475 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE The effects of both compounds on cell invasion are dependent on p53 and imply that α-dicarbonyls could be efficacious in the treatment of p53-expressing invasive liver tumors. 24071451 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE We investigated the role of XPD in cell apoptosis of hepatoma and its relationship with p53 during the regulation of hepatoma bio-behavior. 21264535 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Targeted stimulation of the caspase-8 promoter by interferons alpha and gamma, cytotoxic drugs or p53 can substantially sensitize hepatoma cells for apoptosis, whereas hepatocellular carcinoma frequently present an inactive caspase-8 gene promoter. 22153863 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Following dosage and ratio optimization, polypolex formed by surface modified nHAP and p53 expressing plasmid was applied in vitro for human hepatoma HePG2 cell, and then in vivo for rabbit hepatic VX2 tumour by injection of polypolex/lipodoil emulsion to the hepatic artery in a tumour-target manner. 22340582 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE An iodized oil emulsion was used as a p53 vector for intra-arterial gene delivery to treat hepatic tumors. 22441128 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE Using short hairpin RNA against p53, transient ectopic expression of wild-type p53 or mutant p53 (R248W or R175H), and a p53- and p21-dependent luciferase reporter assay, we demonstrated that growth arrest and apoptosis of FaDu (human pharyngeal squamous cell carcinoma), Hep3B (hepatoma), and MG-63 (osteosarcoma) cells induced by aloe-emodin (AE) are p53-independent. 21308745 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation. 21563203 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Here we have shown that the LIM domain protein Enigma directly interacts with MDM2 to form a ternary complex with p53 in vitro and in human hepatoma and colon carcinoma cell lines and mouse embryonic fibroblasts. 21060154 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. 21112564 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Human inhibitor of growth 1 inhibits hepatoma cell growth and influences p53 stability in a variant-dependent manner. 19085961 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE The expression of p27, p21 and p53 was assessed in well and poorly-differentiated liver tumors. 19672859 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group LHGDN Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations. 17962810 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Enhancement of p53 gene transfer efficiency in hepatic tumor mediated by transferrin receptor through trans-arterial delivery. 18347429 2008