Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6338
Gene Symbol: SCNN1B
SCNN1B
0.530 Biomarker group BEFREE However, its role in CF lung disease pathogenesis remains unclear.In this study, β-epithelial Na<sup>+</sup> channel-overexpressing transgenic (βENaC-Tg) mice, a model of CF-like lung disease, were crossed with CatS null (CatS<sup>-/-</sup>) mice or treated with the CatS inhibitor VBY-999.Levels of active CatS were elevated in the lungs of βENaC-Tg mice compared with wild-type (WT) littermates. 30655278 2019
Entrez Id: 6338
Gene Symbol: SCNN1B
SCNN1B
0.530 Biomarker group BEFREE Studies of the phenotype of βENaC-transgenic mice demonstrated that increased airway Na(+) absorption causes airway surface liquid (ASL) depletion, reduced mucus transport and a spontaneous CF-like lung disease with airway mucus obstruction and chronic airway inflammation. 21658636 2011
Entrez Id: 6338
Gene Symbol: SCNN1B
SCNN1B
0.530 Biomarker group BEFREE The finding that TNFRSF1A, SCNN1B and SCNN1G are clinically relevant modulators of CF disease supports current concepts that the depletion of airway surface liquid and inadequate host inflammatory responses trigger pulmonary disease in CF. 16463024 2006
Entrez Id: 6338
Gene Symbol: SCNN1B
SCNN1B
0.530 Biomarker group CTD_human Mutations in the beta-subunit of the epithelial Na+ channel in patients with a cystic fibrosis-like syndrome. 16207733 2005
Entrez Id: 6338
Gene Symbol: SCNN1B
SCNN1B
0.530 Biomarker group GENOMICS_ENGLAND