Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 Biomarker group BEFREE SP-B pre-proteins might serve as a biomarker in pulmonary diseases with alveolar or interstitial damage such as ILDs, especially in IPF. 29763900 2018
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 GeneticVariation group BEFREE Previous studies have indicated that a SP-B 1580C/T polymorphism (SNP rs1130866) was associated with lung diseases including pneumonia. 26620227 2016
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 Biomarker group BEFREE Mutations of genes affecting surfactant homeostasis, such as SFTPB, SFTPC and ABCA3, lead to diffuse lung disease in neonates and children. 21867529 2011
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 GeneticVariation group BEFREE Individuals heterozygous for this mutation have partial absence of surfactant protein-B and could be at risk of lung disease when exposed to additional risk factors for impaired surfactant function such as tobacco smoking. 19833825 2010
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 Biomarker group RGD [Expression of HoxB5 mRNA and their effect on lung development in premature rats with hyperoxia-induced chronic lung disease]. 19099817 2008
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 Biomarker group BEFREE In this study we tested whether SP-B was in association with two further pulmonary diseases in children, i. e. severe infections caused by respiratory syncytial virus and bronchial asthma. 17498296 2007
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 GeneticVariation group BEFREE The genes encoding SP-B (SFTPB), SP-C (SFTPC), and ABCA3 (ABCA3) were sequenced from the parents of one infant and two unrelated infants with fatal neonatal lung disease. 17429902 2007
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 GeneticVariation group BEFREE Pulmonary surfactant is essential to maintain alveolar patency, and invariably fatal neonatal lung disease has been recognized to involve mutations in the genes encoding surfactant protein-B or ATP-binding cassette transporter family member ABCA3. 17660803 2007
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 GeneticVariation group LHGDN Differences in amounts of SP-B resulting from the promoter SNP could affect the clinical presentation of pulmonary disease. 17071721 2007
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 Biomarker group CTD_human Effects of antioxidant vitamins on molecular regulators involved in lung hypoplasia induced by nitrofen. 16863852 2006
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 GeneticVariation group BEFREE The results indicate that intron 4 length variants affect SP-B mRNA splicing, and that this may contribute to lung disease. 15790313 2005
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 GeneticVariation group LHGDN The results indicate that intron 4 length variants affect SP-B mRNA splicing, and that this may contribute to lung disease. 15790313 2005
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 Biomarker group BEFREE Immunohistochemical analysis of surfactant protein expression in three patients revealed a specific staining pattern for surfactant protein-B, which was the same pattern observed in several infants with fatal lung disease due to ABCA3 mutations. 15976379 2005
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 GeneticVariation group BEFREE Surfactant Protein B (SP-B) deficiency has been recently identified as an uncommon, autosomal recessive lung disorder in term infants. 15027668 2004
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 GeneticVariation group LHGDN This work reviews the current state of knowledge concerning the lung diseases associated with mutations in the SP-B and SP-C genes, and the potential roles of abnormal SP-B and SP-C expression and genetic variation in these genes in other lung diseases. 14977415 2004
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 GeneticVariation group BEFREE This work reviews the current state of knowledge concerning the lung diseases associated with mutations in the SP-B and SP-C genes, and the potential roles of abnormal SP-B and SP-C expression and genetic variation in these genes in other lung diseases. 14977415 2004
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 AlteredExpression group BEFREE In a number of inflammatory diseases of the lung, elevated nitric oxide (NO) levels are associated with decreased SP-B levels, suggesting that reduced SP-B levels contribute to lung injury. 12896877 2003
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 Biomarker group BEFREE The population frequency of five known and four novel SNPs was studied, providing as many potential markers for pulmonary disease related to SFTPB. 12784301 2003
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 GeneticVariation group BEFREE The SP-B SNP B1580_C (odds ratio:7.63; confidence interval:1.64-35.4; P</=0.01), to be a risk factor for IPF smokers, has also been shown to be a risk factor for other pulmonary diseases. 13680361 2003
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 GeneticVariation group BEFREE Allelic variations of the SP-A and SP-B genes have been shown to be important genetic determinants in individual susceptibility to RDS, which is a good general model for a multifactorial pulmonary disease resulting from complex interactions between several environmental and genetic factors. 12452477 2002
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 Biomarker group BEFREE SP-B deficiency or dysfunction may be more common than once thought and may play a significant role in neonatal lung disease. 11202476 2001
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 Biomarker group BEFREE The development of peptide analogues of SP-B and SP-C offers the possibility to study their molecular mechanism of action and will allow the design of surfactant formulations for specific pulmonary diseases and better quality control. 11001826 2000
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 Biomarker group BEFREE We conclude that a novel splicing mutation was the cause of lung disease in these children and that hereditary SP-B deficiency can be the cause of lung disease in older children. 10960490 2000
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 GeneticVariation group BEFREE Hereditary surfactant protein B (SP-B) deficiency is an uncommon autosomal recessive lung disorder that causes hypoxemic respiratory failure in mature, morphologically normal infants. 11041444 2000
Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
0.600 GeneticVariation group BEFREE Compound SFTPB 1549C-->GAA (121ins2) and 457delC heterozygosity in severe congenital lung disease and surfactant protein B (SP-B) deficiency. 10571948 1999