Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.330 Biomarker disease BEFREE LncRNA‑mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive pulmonary disease. 28339038 2017
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.330 Biomarker disease CTD_human Here, we examined the mechanisms underlying decreased FoxO3A activation and its modulation by quercetin in COPD human airway epithelial cells and in a COPD mouse model. 23099361 2013
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.330 Biomarker disease CTD_human Effects of quercetin on lung chemokine expression, nuclear FoxO3A levels and phosphorylation of EGFR and Akt were determined in COPD mouse model. 23099361 2013
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.330 Biomarker disease CTD_human Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A. 23099361 2013
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.330 Biomarker disease CTD_human COPD bronchial biopsies also showed reduced nuclear FoxO3A. 23099361 2013
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.330 Biomarker disease CTD_human Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt. 23099361 2013
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.330 Biomarker disease CTD_human In COPD airways, aberrant EGFR activity increases PI 3-kinase/Akt-mediated phosphorylation of FoxO3A, thereby decreasing nuclear FoxO3A and increasing chemokine expression. 23099361 2013
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.330 Biomarker disease CTD_human Compared with normal, COPD cells showed significantly increased IL-8, which negatively correlated with nuclear FoxO3A levels. 23099361 2013
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.330 AlteredExpression disease BEFREE Similar protective effects of Vam3, reducing autophagy and restoring the levels of Sirt1 and FoxO3a, were observed in the COPD animal model. 22705731 2012
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.330 Biomarker disease BEFREE FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease. 21690325 2011