Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Both miR-34c-5p agomir and CCL22 shRNA could reduce breathing frequency (f), airway resistance (RI), and the levels of IL-8 and TNF-α in BALF of COPD rats with increased Cydn (dynamic lung compliance) and PIF (peak inspiratory flow). 31032652 2020
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Our study found two hypomethylation-high-expression genes (CXCL3 and CXCL8) in COAD tissues compared with the adjacent normal tissues. 31709538 2020
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE For inflammatory cytokines, lncRNA ANRIL expression was negatively correlated with TNF-α (P < 0.001), IL-1β (P = 0.015), IL-8 (P = 0.008), IL-17A (P = 0.002), and LTB-4 (P = 0.004) in AECOPD patients, while it was negatively correlated with TNF-α (P = 0.049), IL-1β (P = 0.005), IL-17A (P = 0.030), and LTB-4 (P = 0.011) in stable COPD patients. 30230590 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE Fluticasone propionate (FP) and dexamethasone (DEX) suppressed IL-6 and IL-8 production in BEAS-2B cells, but clarithromycin (CAM) failed to do so.<b>Conclusions:</b><i>P. aeruginosa</i>-derived flagellin-induced IL-6 and IL-8 production in bronchial epithelial cells, which partially explains the mechanisms of progression and exacerbation of COPD. 31517562 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE BRD4 is increased in the lung of patients with COPD and is correlated with miR-29b and IL-8 expression. miR-29b regulates cigarette smoke extract (CSE)-induced IL-8 expression by targeting BRD4 in HBE cells. 30652495 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE The relationship between CCSP/IL8 concentration ratios in the supernatant of induced sputum from COPD patients <i>versus</i> neutrophilic airway infiltration assessed in lung biopsies was assessed.Increased neutrophilic chemotactic activity of CSE-treated ALI cultures followed IL8 concentrations and returned to normal when supplemented with rhCCSP. rhIL8-induced chemotaxis of neutrophils was reduced by rhCCSP. rhCCSP and rhIL8 co-immunoprecipitated. 31023848 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE COPD airway epithelial cells showed attenuated IL-8 responses to TLR2 agonist despite expressing TLR2 similar to normal, indicating dysregulation in TLR2 signaling pathway. 31548332 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Moreover, treatment with LPNs efficiently ameliorated the steroid resistance in COPD models <i>in vitro</i> as evidenced by the lowered expression levels of IL-8. 31809610 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE Moreover, the values of neutrophils (61.8%±15.1%), MPO (574.0±111.8 ng/mL), and IL-8 (32.6±13.4 ng/mL) in induced sputum in stable COPD patients with positive BD tests were significantly higher than those in asthmatics or normal controls (all P<0.01). 31346991 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE LABAs and p38MAPK Inhibitors Reverse the Corticosteroid-Insensitivity of IL-8 in Airway Smooth Muscle Cells of COPD. 31766770 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE We evaluated overall higher numbers of IL-7, IL-8 and IL-10 (mostly from few (0/+) to almost abundance (++++)) and overall less numbers of IL-1α and IL-6 (mostly from no positive (0) to numerous to abundance (+++/++++)) immunoreactive cells in airway epithelium and connective tissue of COPD affected lung. 30392917 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE CSE alone elevated cytokine secretion in all examined cells. rhHsp70 and CSE had antagonistic interactions on IL-8 release in PBECs from COPD patients, while the addition of rhHsp70 further increased CSE-induced IL-6 secretion in NHBE cells. rhHsp70 and CSE alone decreased TLR2 and TLR4 mRNA expression in COPD-derived PBECs. 30268700 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Interestingly, MCP-1 level was higher only in COPD-E versus CSs and CNSs; EGF and IL-8 levels were higher in COPD-B and COPD-E versus CNSs; IL-6 level was increased in all three smoking groups (COPD-B, COPD-E, and CSs) versus CNS; IFN-γ and IL-1α levels were higher in CSs than in CNSs; and IL-1α level was also higher in CSs versus COPD-B and COPD-E. 29872287 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE In the Jinwei Tang + budesonide and theophylline + budesonide groups, IL-8 and TNF-α expression was significantly decreased (P<0.05) and the HDAC2 level increased (P<0.05) compared with that in the COPD group. 29456664 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Sputum CXCL1 levels is a potentially better diagnostic marker for COPD than sputum CXCL8 levels, which is explained by that CXCL1 production in bronchial epithelial cells is less affected by therapeutic anti-inflammatory agents than CXCL8 production. 30676127 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE Serum levels (median [interquartile range]) of IL-5 were higher in asthma patients than in COPD patients (2.09 [0.61-3.57] vs 1.11 [0.12-2.42] pg/mL, respectively; <i>p</i>=0.03), and IL-8 levels (median [interquartile range]) were higher in COPD patients than in asthma patients (9.45 [6.61-13.12] vs 7.03 [4.69-10.44] pg/mL, respectively; <i>p</i><0.001). 29483774 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE Statistical analyses revealed that changes in viral communities correlate most with changes in levels of arachidonic acid and IL-8, both potentially relevant for chronic obstructive pulmonary disease (COPD) pathogenesis based on prior studies. 30208886 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE IL-8-dependent inflammation is a hallmark of host lung innate immunity to bacterial pathogens, yet in many human lung diseases, including chronic obstructive pulmonary disease, bronchiectasis, and pulmonary fibrosis, there are progressive, irreversible, pathological changes associated with elevated levels of IL-8 in the lung. 29894204 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE In both COPD and healthy control cultures, MWCNTs neither caused increased release of lactate dehydrogenase (LDH), nor alterations in inflammatory responses, as measured by RNA expression and protein secretion of the cytokines IL-6, IL-8, CXCL10, IL-1β and TGF-β and oxidative stress markers HMOX-1 and SOD-2. 29804489 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE We previously evidenced that thyme extract reduce IL-1beta and IL-8, by downregulating the activated NF-κB levels, suggesting its potential therapeutically use in COPD. 30021361 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE There were no significant differences in the number of subjects with high levels of inflammatory biomarkers (>90th percentile of never-smokers without COPD), including white blood cell count, total bilirubin, interleukin (IL)-6, IL-8, and C-reactive protein, or radiologic measurements (including emphysema index and mean wall area percentage) between never-smokers with COPD and those without COPD. 29117798 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE Furthermore, IL-8 has been shown to be a pro-inflammatory marker in bronchiectasis, COPD and allergic asthma. 30380761 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE The concentrations of CXCL5, CXCL8/IL-8 and VEGF were higher in conditioned medium (CM) harvested from HBECs after exposure to COPD serum as compared to controls. 30154415 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE The cell response was evaluated by measuring the expression of IL-8 and IL-10, respectively, pro- and anti-inflammatory cytokines involved in COPD pathogenesis, as well as of pertinent TLR-4 pathway mediators. 28976240 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease CTD_human MicroRNA-218 acts by repressing TNFR1-mediated activation of NF-κB, which is involved in MUC5AC hyper-production and inflammation in smoking-induced bronchiolitis of COPD. 28864214 2017