Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Here, we examined the relationship between circulating serpina3g, matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 and -2 (TIMP-1 and -2, respectively) and severity of COPD. 30781876 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Baseline plasma concentration of anti-elastin antibodies and elastin-degrading enzymes (eg, matrix metalloproteinase-9, and -12, and neutrophil elastase) were measured in the same cohort. elastin fragment-specific CD 4<sup>+</sup> T cell expression of interferon-γ, and anti-elastin antibodies were dependent on history of smoking in TAA / TAD patients but were independent of chronic obstructive pulmonary disease. 30957625 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE By anchoring MMP-8 and MMP-9 to PMN surfaces, membrane-bound TIMP-1 plays a counterintuitive role in promoting PMN pericellular proteolysis occurring in chronic obstructive pulmonary disease and other diseases. 31019060 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Additionally, the significant inverse relationships between parameters of lung function (FEV<sub>1</sub>% and FEV<sub>1</sub>/FVC) and proteins level were found in ridge regression models, especially we found that FEV<sub>1</sub>% decreased when MMP-9 level increased in controls and patients with COPD group. 30643813 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE The level of MMP-9 was significantly higher in COPD patients with >3 comorbidities, a COTE index of ≥4 and cardiovascular disease as well as coronary heart disease (t=6.40, 2.53, 3.65 and 2.90, P<0.05). 30542429 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Additionally, specific activation of phosphoinositide 3‑kinase (PI3K) signaling, using insulin‑like growth factor‑1 (IGF‑1), promoted cell proliferation and cell cycle progression, increased expression of TGFβ1, FGF‑1, PI3K, AKT, phospho‑AKT, serine/threonine‑protein kinase mTOR (mTOR), phospho‑mTOR and TIMP1, promoted cell migration capacity and reduced the expression level of MMP‑9 in cells from COPD rats. 30066869 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Therefore, this study aimed to evaluate the effect of conjugated linoleic acid (CLA) supplement as natural antioxidants on oxidative stress levels, and MMP2 and MMP9 serum levels in COPD patients. 29765212 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Serum CyPA positively correlated with serum interleukin-6, matrix metalloproteinase-9 and high-sensitivity C-reactive protein in both the exacerbation and convalescence phases of COPD. 29403273 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE The levels of innate defense proteins associated with chronic obstructive pulmonary disease, such as elastase and matrix metalloproteinase-9, were significantly elevated in e-cigarette users as well. 29053025 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE A COPD model was employed by exposing mice to cigarette smoke and the expression levels of MMP-9 and MMP-12 were significantly increased in the lungs. 29358724 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE In adjusted models within each cohort, elevated MMP-9 was associated with increased odds (odds ratio [OR], 1.71; 95%CI, 1.00-2.90; and OR, 3.03; 95%CI, 1.02-9.01), frequency (incidence rate ratio [IRR], 1.45; 95%CI, 1.23-1.7; and IRR, 1.24; 95%CI, 1.03-1.49), and shorter time-to-first AECOPD (21.7 versus 31.7 months and 14 versus 21 months) in SPIROMICS and COPDGene, respectively. 30429371 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE However, concentration ratio of MMP-9 released from PMN exposed to 4% CSE or 0% CSE of each participant was significantly higher for healthy subjects than for COPD patients (P = 0.025). 29222599 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE While the triad discriminated between smokers and non-smokers in the COPD group, MMP-9 and proMMP-9/NGAL (but not NGAL) discriminated between smokers with and without COPD. 28004483 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Study on the expression of Toll-like receptor 4 and matrix metalloproteinase-9 in patients with chronic obstructive pulmonary disease and their clinical significance. 28537664 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Effect of Liuweibuqi capsules on the balance between MMP-9 and TIMP1 and viability of alveolar macrophages in COPD. 28831024 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE To determine whether the circulating levels of inflammatory markers, Tn-C and MMP-9 are associated with LVDD in COPD patients. 26663885 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE PPARγ and TIMP-1 concentrations were decreased and the concentration of MMP-9 and the ratio of MMP9/TIMP1 were enhanced in the induced sputum of COPD patients, compared to the healthy controls. 29268377 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Finally, the authors refer to the studies on MMP-9 inhibition as a new perspective for increasing the effectiveness of treatment in asthma and COPD. 26123447 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 GeneticVariation disease BEFREE Our study is the first to reveal an interaction between the MMP9-1562T allele and cigarette smoke in COPD, emphasising gene-environment interactions as a possible cause of lung damage in the pathogenesis of COPD.. 27270564 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 GeneticVariation disease BEFREE Based on our meta-analysis, MMP-9 rs3918242 C > T is correlated with susceptibility to COPD, but MMP-1 rs1799750 1G > 2G and MMP-3 rs3025058 5A > 6A are not. 27173221 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Therapeutic disease RGD Liuweibuqi capsules can improve the symptoms of COPD possibly by regulating the expression of the JAK1/STAT3 pathway and MMP9/TIMP1. 25842729 2015
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Taken together, our results suggest that MMP-9 serves as a biomarker for the grade and severity of COPD. 26291981 2015
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 GeneticVariation disease BEFREE Matrix Metalloproteinase-9 (279R/Q) Polymorphism is Associated with Clinical Severity and Airflow Limitation in Tunisian Patients with Chronic Obstructive Pulmonary Disease. 26303146 2015
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Polymorphisms in MMP2 and MMP9 but not in MMP1 and MMP12 are associated with the risk of COPD in the Mexican mestizo population. 26439471 2015
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Moreover, inhibiting Src deterred the cigarette smoke-mediated induction of matrix metalloproteinase-9 and -12 in alveolar macrophages and lung expression of cathepsin K, IL-17, TNF-α, MCP-1, and KC, all key factors in the pathogenesis of COPD. 24111605 2014