Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker group BEFREE This work helps explain the nuclear accumulation of PTEN observed in many healthy tissues and, because <i>Ipo11</i> mutant mice develop lung tumors, also implicates Importin-11 as a novel tumor suppressor. 28193699 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker group CTD_human The ISG15-specific protease USP18 regulates stability of PTEN. 27980214 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker group BEFREE These findings explain the correlation between loss of IPO11 and PTEN protein in human lung tumors. 28193700 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker group BEFREE To investigate the effect of olaparib and cisplatin on PTEN-deficient lung tumors, two EGFR-mutant (deletion in exon19) non-small cell lung cancer (NSCLC) cell lines, PC-9 (PTEN wild-type) and H1650 (PTEN loss), were used. 23239809 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker group BEFREE To explore the spectrum of driver mutations among lung cancer tissues from never smokers, specifically in a population where high lung cancer rates have been attributed to indoor air pollution from domestic coal use, multiplexed assays were used to detect >40 point mutations, insertions, and deletions (EGFR, KRAS, BRAF, HER2, NRAS, PIK3CA, MEK1, AKT1, and PTEN) among the lung tumors of confirmed never smoking females from Xuanwei, China [32 adenocarcinomas (ADCs), 7 squamous cell carcinomas (SCCs), 1 adenosquamous carcinoma (ADSC)]. 24055406 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker group CTD_human Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. 17909629 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression group LHGDN PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors. 17912443 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression group LHGDN Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. 15802268 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker group BEFREE To determine whether SP-A aberrations are lung cancer-specific and indicate smoking-related damage, tricolor fluorescence in situ hybridization with SP-A and PTEN probes was done on touch imprints from the lung tumors obtained prospectively from 28 patients with primary NSCLC. 16061856 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker group BEFREE Mutations of this gene are common in brain, prostate, endometrial, and gastric cancers but occur rarely in non-small-cell lung cancer (NSCLC), although the PTEN protein is often lost in lung tumors. 16084946 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 PosttranslationalModification group LHGDN RRM1-induced metastasis suppression through PTEN-regulated pathways. 12687015 2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation group BEFREE All the lung tumors with PTEN/MMAC1/TEP1 mutations were homozygous for the mutant alleles. 9598803 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker group HPO
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GenomicAlterations group CGI
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 CausalMutation group CGI