Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.590 Biomarker group CTD_human The ISG15-specific protease USP18 regulates stability of PTEN. 27980214 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.590 Biomarker group BEFREE To explore the spectrum of driver mutations among lung cancer tissues from never smokers, specifically in a population where high lung cancer rates have been attributed to indoor air pollution from domestic coal use, multiplexed assays were used to detect >40 point mutations, insertions, and deletions (EGFR, KRAS, BRAF, HER2, NRAS, PIK3CA, MEK1, AKT1, and PTEN) among the lung tumors of confirmed never smoking females from Xuanwei, China [32 adenocarcinomas (ADCs), 7 squamous cell carcinomas (SCCs), 1 adenosquamous carcinoma (ADSC)]. 24055406 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.590 Biomarker group BEFREE To investigate the effect of olaparib and cisplatin on PTEN-deficient lung tumors, two EGFR-mutant (deletion in exon19) non-small cell lung cancer (NSCLC) cell lines, PC-9 (PTEN wild-type) and H1650 (PTEN loss), were used. 23239809 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.590 GeneticVariation group BEFREE The triciribine/tipifarnib synergistic effects are seen with several cancer cell lines including those from breast, leukemia, multiple myeloma and lung tumors with different genetic alterations such as K-Ras, B-Raf, PI3K (phosphoinositide 3-kinase), p53 and pRb mutations, PTEN, pRB and Ink4a deletions, and ErbB receptor overexpression. 21536547 2011
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.590 AlteredExpression group LHGDN Western blot analysis showed that six out of 25 (24%) lung cancer cell lines displayed low expression of PTEN protein. 17912443 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.590 Biomarker group CTD_human Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. 17909629 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.590 Biomarker group BEFREE To determine whether SP-A aberrations are lung cancer-specific and indicate smoking-related damage, tricolor fluorescence in situ hybridization with SP-A and PTEN probes was done on touch imprints from the lung tumors obtained prospectively from 28 patients with primary NSCLC. 16061856 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.590 Biomarker group BEFREE Mutations of this gene are common in brain, prostate, endometrial, and gastric cancers but occur rarely in non-small-cell lung cancer (NSCLC), although the PTEN protein is often lost in lung tumors. 16084946 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.590 AlteredExpression group LHGDN EGF and hypoxia induce CXCR4 in non-small cell lung cancer, a process regulated by the PI3-kinase/PTEN/AKT/mTOR signaling pathway and activation of HIF-1alpha 15802268 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.590 PosttranslationalModification group LHGDN overexpression of RRM1 in human and mouse lung cancer cell lines induced PTEN expression, reduced phosphorylation of focal adhesion kinase (FAK), suppressed migration, invasion, and metastasis formation, and increased survival in an animal model. 12687015 2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.590 GeneticVariation group BEFREE All the lung tumors with PTEN/MMAC1/TEP1 mutations were homozygous for the mutant alleles. 9598803 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.590 CausalMutation group CGI
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.590 GenomicAlterations group CGI