Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1776
Gene Symbol: DNASE1L3
DNASE1L3
0.470 AlteredExpression disease BEFREE DNase activity was decreased in iLN compared to SLE (20% had one-half DNase activity) despite similar serum levels of DNase1/DNase1L3. 31092713 2020
Entrez Id: 1776
Gene Symbol: DNASE1L3
DNASE1L3
0.470 GeneticVariation disease GWASCAT Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. 30573655 2019
Entrez Id: 1776
Gene Symbol: DNASE1L3
DNASE1L3
0.470 Biomarker disease BEFREE Rare Mendelian forms have been reported, including DNASE1L3-related SLE. 27821515 2017
Entrez Id: 1776
Gene Symbol: DNASE1L3
DNASE1L3
0.470 Biomarker disease BEFREE Pediatric-onset systemic lupus erythematosus arises in humans and mice lacking the endonuclease Dnase1L3. 28533778 2017
Entrez Id: 1776
Gene Symbol: DNASE1L3
DNASE1L3
0.470 AlteredExpression disease BEFREE We found a decrease in DNase1l3 level in the DM/PM and SLE patients, resulting in the reduction in serum activity to digest nucleosome DNA. 28039554 2017
Entrez Id: 1776
Gene Symbol: DNASE1L3
DNASE1L3
0.470 Biomarker disease BEFREE Murine and human autoantibody clones and serum antibodies from human SLE patients bind to DNASE1L3-sensitive chromatin on the surface of microparticles. 27293190 2016
Entrez Id: 1776
Gene Symbol: DNASE1L3
DNASE1L3
0.470 GeneticVariation disease BEFREE These results show that HUVS is caused by mutations in DNASE1L3, encoding an endonuclease that previously has been associated with SLE. 23666765 2013
Entrez Id: 1776
Gene Symbol: DNASE1L3
DNASE1L3
0.470 Biomarker disease BEFREE The DNASE1L3-related SLE we describe was always pediatric in onset and correlated with a high frequency of lupus nephritis. 22019780 2011
Entrez Id: 1776
Gene Symbol: DNASE1L3
DNASE1L3
0.470 Biomarker disease CTD_human The DNASE1L3-related SLE we describe was always pediatric in onset and correlated with a high frequency of lupus nephritis. 22019780 2011
Entrez Id: 1776
Gene Symbol: DNASE1L3
DNASE1L3
0.470 Biomarker disease HPO