Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.470 | AlteredExpression | disease | BEFREE | DNase activity was decreased in iLN compared to SLE (20% had one-half DNase activity) despite similar serum levels of DNase1/DNase1L3. | 31092713 | 2020 | ||||
|
0.470 | GeneticVariation | disease | GWASCAT | Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. | 30573655 | 2019 | ||||
|
0.470 | Biomarker | disease | BEFREE | Rare Mendelian forms have been reported, including DNASE1L3-related SLE. | 27821515 | 2017 | ||||
|
0.470 | Biomarker | disease | BEFREE | Pediatric-onset systemic lupus erythematosus arises in humans and mice lacking the endonuclease Dnase1L3. | 28533778 | 2017 | ||||
|
0.470 | AlteredExpression | disease | BEFREE | We found a decrease in DNase1l3 level in the DM/PM and SLE patients, resulting in the reduction in serum activity to digest nucleosome DNA. | 28039554 | 2017 | ||||
|
0.470 | Biomarker | disease | BEFREE | Murine and human autoantibody clones and serum antibodies from human SLE patients bind to DNASE1L3-sensitive chromatin on the surface of microparticles. | 27293190 | 2016 | ||||
|
0.470 | GeneticVariation | disease | BEFREE | These results show that HUVS is caused by mutations in DNASE1L3, encoding an endonuclease that previously has been associated with SLE. | 23666765 | 2013 | ||||
|
0.470 | Biomarker | disease | BEFREE | The DNASE1L3-related SLE we describe was always pediatric in onset and correlated with a high frequency of lupus nephritis. | 22019780 | 2011 | ||||
|
0.470 | Biomarker | disease | CTD_human | The DNASE1L3-related SLE we describe was always pediatric in onset and correlated with a high frequency of lupus nephritis. | 22019780 | 2011 | ||||
|
0.470 | Biomarker | disease | HPO |