Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 Biomarker disease BEFREE In conclusion, JP may inhibit the activation of peritoneal macrophages in MRL/lpr mice by downregulating the IRAK1-NF-<i>κ</i>B signaling pathway, and IRAK1 may be a potential target for JP treatment of SLE. 31781262 2019
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 Biomarker disease BEFREE Interleukin-1 receptor-associated kinase 1 (IRAK1) is associated with the susceptibility of SLE in humans and paeoniflorin has recently been reported to exhibit immunosuppressive properties. 30149133 2018
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 Biomarker disease BEFREE In vitro experiments showed that lupus CD4<sup>+</sup> T cells had more pronounced IRAK1 phosphorylation at threonine-209 upon IL-1β stimulation than did control cells. 29611775 2018
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 Biomarker disease BEFREE Therefore, IRAK1 may be a potential target for anti-inflammatory therapy for SLE and other inflammatory diseases. 28431280 2017
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 AlteredExpression disease BEFREE Lupus development in BXSB mice expressing the Y chromosome autoimmunity accelerator (Yaa) increased basal and Toll-like receptor (TLR) 4/7-induced phosphorylation of mitogen-activated protein kinases, p65 nuclear factor-κB (NF-κB), enhanced tumor necrosis factor (TNF)-α and C-C motif chemokine ligand (CCL) 5 gene expression in splenic macrophages, but decreased levels of Toll-interacting protein and IRAK-M, without affecting IRAK4 or IRAK1 expression. 28295231 2017
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 GeneticVariation disease GWASCAT Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture. 26606652 2016
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 SusceptibilityMutation disease ORPHANET These data suggest contributions of both IRAK1 and MECP2 to SLE susceptibility. 22904263 2013
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 SusceptibilityMutation disease ORPHANET Our data demonstrate that the polymorphisms rs3027898 and rs1059702 of IRAK1 gene are associated with SLE in the Chinese Han population. 23435933 2013
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 SusceptibilityMutation disease ORPHANET Genetics and epigenetics of systemic lupus erythematosus. 23943494 2013
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 GeneticVariation disease BEFREE Our data demonstrate that the polymorphisms rs3027898 and rs1059702 of IRAK1 gene are associated with SLE in the Chinese Han population. 23435933 2013
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 GeneticVariation disease BEFREE Our data suggest that the lupus-associated variant in the MECP2/IRAK1 locus has the potential to affect all 3 epigenetic mechanisms: DNA methylation, microRNA expression, and histone modification. 23428850 2013
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 Biomarker disease BEFREE These data suggest contributions of both IRAK1 and MECP2 to SLE susceptibility. 22904263 2013
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 Biomarker disease BEFREE As IRAK1 has been regarded a crucial gene in the pathogenesis of systemic lupus erythematosus, TRAF6 can be a Sjögren's syndrome specific biomarker, confirming and partly explaining the existance of different pathogenic pathways in the two diseases. 22033216 2012
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 SusceptibilityMutation disease ORPHANET Role of cytokines in systemic lupus erythematosus: recent progress from GWAS and sequencing. 22654485 2012
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 GeneticVariation disease BEFREE We tested for an association with the IRAK1 SLE risk haplotype in a discovery set of 849 SSc patients and 625 controls. 21898345 2011
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 SusceptibilityMutation disease ORPHANET Recent insights into the genetic basis of systemic lupus erythematosus. 19440199 2009
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 SusceptibilityMutation disease ORPHANET Family-based TDT showed a significant association of SLE with a N673S polymorphism in the P-selectin gene (SELP) (P = 5.74 x 10(-6)) and a C203S polymorphism in the interleukin-1 receptor-associated kinase 1 gene (IRAK1) (P = 9.58 x 10(-6)). 18050247 2007
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 Biomarker disease LHGDN Family-based TDT showed a significant association of SLE with a N673S polymorphism in the P-selectin gene (SELP) (P = 5.74 x 10(-6)) and a C203S polymorphism in the interleukin-1 receptor-associated kinase 1 gene (IRAK1) (P = 9.58 x 10(-6)). 18050247 2007
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 GeneticVariation disease BEFREE Family-based TDT showed a significant association of SLE with a N673S polymorphism in the P-selectin gene (SELP) (P = 5.74 x 10(-6)) and a C203S polymorphism in the interleukin-1 receptor-associated kinase 1 gene (IRAK1) (P = 9.58 x 10(-6)). 18050247 2007
Entrez Id: 3654
Gene Symbol: IRAK1
IRAK1
0.500 Biomarker disease HPO