Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 AlteredExpression disease BEFREE Taken together, our results uncovered a mechanistic insight of a noncoding functional variant acting as an allele-specific distal enhancer to directly modulate IRF5 expression, which might obligate in understanding of complex genetic architectures of SLE and SSc pathogenesis. 31421124 2020
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease BEFREE Genetic variants within or around the transcription factor interferon regulatory factor 5 (IRF5) associate with SLE risk. 31130331 2019
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease BEFREE This meta-analysis confirms that the IRF5 rs2004640 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent. 31018759 2019
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease BEFREE We identified Interferon regulating factor 5 (IRF5), solute carrier family 22 member 2 (SLC22A2) and S100 calcium binding protein A12 (S100A12) as the three proteins with the largest fold change between SLE patients and controls (SLE/Control = 1.4, 1.4, and 1.2 respectively). 31156624 2019
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 Biomarker disease BEFREE It has become clear that IRF5 contributes to the pathogenesis of many inflammatory and autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease and systemic lupus erythematosus. 30199605 2019
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 Biomarker disease BEFREE Studies of IRF5 expression and function in genotyped healthy donors will address the question of whether IRF5 dysregulation in SLE is driven by genetic or non-genetic factors. 30645688 2019
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease BEFREE The current study suggested that individuals carrying rs2004640 T allele correlated with a high risk of SLE, and the IRF5 rs2004640 polymorphism was associated with SLE susceptibility. 31347288 2019
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease BEFREE However, IRF5 and TNFAIP3 gene alleles, established risk factors for SLE in populations of European and Asian ancestry, are not significantly associated with SLE in this cohort. 31032751 2019
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease GWASCAT Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. 30573655 2019
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 Biomarker disease BEFREE Therefore, IRF5 is an important therapeutic target of SLE, and selective suppression of its activity and expression may potentially lead to the development of new therapies. 29860420 2018
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease BEFREE Our study revealed that the IRF5 rs2004640 polymorphism was not a risk factor for SLE in population from south India. 30168487 2018
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease BEFREE Enhanced ABC formation in SWEF-deficient mice was controlled by the cytokine IL-21 and IRF5, whose variants are strongly associated with lupus. 29483597 2018
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 Biomarker disease BEFREE Here, we evaluated the major SLE risk haplotype of IRF5 on the functional attributes of freshly isolated B cells from human subjects who do not have evidence of SLE or other forms of autoimmunity. 29867973 2018
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 Biomarker disease BEFREE Genome-wide association studies have implied the association of IRF5 with several autoimmune diseases, including systemic lupus erythematosus (SLE), Sjogren's syndrome, inflammatory bowel disease and multiple sclerosis. 28578407 2017
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease BEFREE Subjects and methods Typing of interferon regulatory factor 5 rs10954213, rs2004640 and rs2280714 polymorphisms were done using polymerase chain reaction-restriction fragment length polymorphism for 100 children with SLE and 100 matched healthy controls. 28059021 2017
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 Biomarker disease BEFREE This study demonstrates the association of IRF5 with an increased susceptibility for SLE in the population of Crete and emphasizes the association of the Neanderthal-derived IRF5 haplotype with SLE susceptibility. 28185859 2017
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease GWASCAT Transancestral mapping and genetic load in systemic lupus erythematosus. 28714469 2017
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 Biomarker disease BEFREE <i>IRF5</i> genetic risk has been widely replicated in systemic lupus erythematosus (SLE), and loss of <i>Irf5</i> ameliorates disease in murine lupus models, in part, through the lack of pathogenic autoantibody secretion. 29367853 2017
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 AlteredExpression disease BEFREE Our results suggest that HDACi may have therapeutic potential in patients with autoimmune diseases such as SLE through repression of IRF5 expression. 28525378 2017
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 Biomarker disease BEFREE Interferon regulatory factor-5 (IRF5), a transcription factor critical for the induction of innate immune responses, contributes to the pathogenesis of the autoimmune disease systemic lupus erythematosus (SLE) in humans and mice. 27521268 2016
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease BEFREE The IRF5-TNPO3 region showed the strongest association and largest OR for SLE (rs10488631: genomic control-adjusted P [Pgcadj ] = 2.61 × 10(-29), OR 2.12 [95% CI 1.88-2.39]), followed by HLA class II on the DQA2-DQB1 loci (rs9275572: Pgcadj  = 1.11 × 10(-16), OR 1.62 [95% CI 1.46-1.80] and rs9271366: Pgcadj  = 6.46 × 10(-12), OR 2.06 [95% CI 1.71-2.50]). 26606652 2016
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease GWASCAT Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus. 27399966 2016
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease BEFREE The IRF5 rs2070197 polymorphism was identified as risk factors for SLE in Caucasian populations (OR 1.82, 95 % CI 1.70-1.96), but it had no effects (monomorphic) in Asians. 26233721 2015
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease GWASCAT Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. 26502338 2015
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.700 GeneticVariation disease BEFREE Furthermore, we found that the SLE-risk variant of the IRF5 CGGGG-indel was associated with lower IFN-α production. 25779693 2015