Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE P-glycoprotein is a product of the multidrug resistance (MDR1) gene, which is a major cause of the refractoriness of malignant lymphomas to conventional chemotherapeutic regimens containing anthracycline. l-asparaginase-containing regimens such as SMILE (steroid, methotrexate, ifosfamide, l-asparaginase, and etoposide) are effective for ENKL. 23768637 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE Drug accumulation was measured in a human ABCB1 gene-transfected mouse lymphoma cell line and in a human lung cancer cell line by flow cytometry; furthermore, their anticancer effects were determined in mice in vivo. 22287739 2012
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE Our results show that P-gp was expressed in histiocytes but not ML cells in LN, and suggest that this molecule may play an important role in the biological function of histiocytes and/or for maintenance of homeostatic levels in T-cell ML LN. 7961124 1994
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicity, reversal of multidrug resistance, apoptosis induction, and interaction with doxorubicin on multidrug resistant human ATP-binding cassette, sub-family B, member 1 (ABCB1) gene-transfected mouse T-lymphoma cell line, and human PC-3 and LNCaP prostate cancer cell lines in vitro. 25862866 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE Compounds 1-25 were evaluated for their effects on the reversion of multidrug resistance (MDR) in cancer cells mediated by P-glycoprotein (P-gp/ABCB1), through combination of functional and chemosensitivity assays, using a human ABCB1-transfected mouse T-lymphoma cell model. 28189906 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE MDR1 RNA levels were also increased in some cancers at relapse after chemotherapy, including ALL, ANLL, breast cancer, neuroblastoma, pheochromocytoma, and nodular, poorly differentiated lymphoma. 2562856 1989
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE Expression of mdr-1 was also detectable in biopsies from patients at the time of diagnosis of lymphoma. 7632959 1995
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE In this study, we examined the expression and activity of P-gp on NK cells derived from three normal donors, six patients with indolent NK cell-lineage granular lymphocyte-proliferative disorder (NK-GLPD), three patients with aggressive NK cell tumors (one NK cell leukemia and two nasal NK cell lymphoma), and two NK cell lines. 9885221 1999
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE There is an increased incidence of de-novo MDR-1 expression in AIDS-related lymphoma compared with lymphoma in the non-HIV settings. 16093797 2005
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE Through use of oligonucleotide hybridization, the genomic content and expression of individual MDR-1 alleles were examined in normal tissues, unselected and drug selected cell lines, and malignant lymphomas. 9473242 1998
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE De novo MDR1 transcript expression was independent of response to therapy in dogs with lymphoma. 9568108 1998
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE Thirteen of 57 lymphomas (23%) showed strong staining of greater than 50% of neoplastic cells; 15 of 57 (26%) showed labeling of a minority (11-50%) of neoplastic lymphocytes; 14 of 57 (25%) yielded equivocal results (reactivity in less than 10% of cells); and 15 of 57 (26%) were negative for P-glycoprotein. 1352183 1992
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation group BEFREE T-25-Adh cells, cell variants derived from S49 mouse lymphoma, were transduced with a retrovirus containing the human MDR1 cDNA. 7786606 1995
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE In order to extend knowledge about pharmacophoric features responsible for ABCB1 inhibitory properties of imidazolidin-2,4-dione derivatives, 1'-[4-(4-(o-methoxyphenyl)-piperazin-1-yl)butyl]-3'-methyl-spiro(fluoren-9,5'-imidazolidine)-2',4'-dione (3) and its salt (4) with rhodanine-3-acetic acid (RA) were prepared and investigated by X-ray diffraction method, as well as their efflux modulating effects in cancer cells (mouse T-lymphoma), cytotoxic and antiproliferative activities were evaluated in vitro. 30586228 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE The effect of MDR-1 substrate drugs has not yet been tested as all patients remain in clinical and radiological remission of their lymphoma. 9614561 1998
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE Despite a considerable variability in the results of these studies investigating Pgp expression in lymphoma, the preponderance of the data suggests that Pgp may at least in part account for drug resistance in this disease. 9498700 1997
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE Compounds 1-14 were evaluated for their MDR-reversing activity on human ABCB1 gene transfected mouse lymphoma cells (L5178Y-MDR) through a combination of functional and chemosensitivity assays. 30199257 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE Since cytochrome P450 3A subfamily (CYP3A) enzymes are involved in the inactivation of chemotherapy drugs, we hypothesized that CYP3A and P-glycoprotein (MDR1) expression in these lymphomas could result in a poor clinical response. 17634410 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE Forty cultured human leukemia and lymphoma cell lines never exposed to anticancer agents in culture, apart from doxorubicin (ADM)-resistant K562/ADM, were examined for reactivity with a monoclonal antibody, MRK16 in F(ab')2 form [MRK16-F(ab')2], which recognizes P-glycoprotein (P-gp). 2575608 1989
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE Retrovirus-mediated transfer of anti-MDR1 ribozymes fully restores chemosensitivity of P-glycoprotein-expressing human lymphoma cells. 10340550 1999
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE To explore the possibility of using anti-B4-bR in combination with chemotherapy protocols, we investigated the in vitro and in vivo cytotoxic effects of combining it with doxorubicin or etoposide using the lymphoma cell line Namalwa and a P-glycoprotein-expressing cell line, Namalwa/mdr-1, obtained by retroviral infection of Namalwa cells with the mdr-1 gene. 7492789 1995
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE A series of novel imidazo[4,5-b]pyridine derivatives were synthesized and their biological activities were evaluated in vitro using parental (PAR) and multidrug resistant (MDR; ABCB1-overexpressing) mouse T-lymphoma cells. 29970523 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE Neither codeinone nor morphine inhibited P-glycoprotein-mediated rhodamine-123 efflux in multidrug resistant mouse T lymphoma L5178 transfected with human MDR 1 gene. 12017290 2002
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE P-glycoprotein expression and phenotypes of lymphoma cells were examined by immunohistochemical staining using UIC2 as an anti-P-gp monoclonal antibody. 8635042 1995
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE Fourteen hydantoin derivatives were synthesized and studied for their capacity to increase accumulation of ethidium bromide (EB) by mouse lymphoma cancer cells that were transfected with the human ABCB1 gene and overexpress the human ABCB1 pump. 22351672 2012