Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
0.390 GeneticVariation disease BEFREE Inactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). 31519498 2019
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
0.390 Biomarker disease BEFREE SIGNIFICANCE: This study provides insights into the dynamic role of CBP/p300 in the differentiation of Tregs, with potential clinical implications in the alteration of the immune landscape in follicular lymphoma. 31182547 2019
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
0.390 GeneticVariation disease BEFREE Pan-HDAC Inhibitors Restore PRDM1 Response to IL21 in CREBBP-Mutated Follicular Lymphoma. 30348636 2019
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
0.390 GeneticVariation disease BEFREE The pathobiology of FL is complex and combines broad somatic changes at the level of both the genome and the epigenome, the latter evidenced by highly recurrent mutations in chromatin-modifying genes such as KMT2D and CREBBP. 29452662 2018
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
0.390 GeneticVariation disease BEFREE We suggest this may parallel the role of CREBBP frameshift/nonsense mutations in DLBCL that result in loss of the protein, but may contrast the role of missense mutations in the lysine acetyltransferase domain that are more frequently observed in FL and yield an inactive protein. 28288979 2017
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
0.390 GeneticVariation disease BEFREE Inactivating mutations of the CREBBP acetyltransferase are highly frequent in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), the two most common germinal center (GC)-derived cancers. 28069569 2017
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
0.390 GeneticVariation disease BEFREE These observations therefore implicate CREBBP mutation as an early event in FL evolution that contributes to immune evasion via decreased antigen presentation. 25713363 2015
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
0.390 Biomarker disease BEFREE The distribution of coding mutations in driver genes and the correlation with SHM suggest CREBBP and AID to be potential modifiers of genetic and epigenetic co-evolution in FL. 25027518 2015
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
0.390 Biomarker disease CTD_human Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. 24362818 2014
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
0.390 GeneticVariation disease BEFREE We report here that the two most common types--follicular lymphoma and diffuse large B-cell lymphoma--harbour frequent structural alterations inactivating CREBBP and, more rarely, EP300, two highly related histone and non-histone acetyltransferases (HATs) that act as transcriptional co-activators in multiple signalling pathways. 21390126 2011