Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE Arguably the MYC activity gain is the most constantly observed phenomenon (>70% of cases) in transformed FL/MALT/CLL (Richter's transformation) and co-occurs with specific aberrations such as the loss of p53, CDKN2A/B, or gain of BCL2/BCL6. 31631728 2020
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE Thus, either DLBCL or FL can give rise to aggressive double-hit lymphomas (DHL) with concurrent activation of MYC and BCL2. 30874346 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE This paper describes how we discovered the juxtaposition of the MYC gene to the human immunoglobulin loci and how that finding was extended to characterize molecularly the t(14;18) chromosome translocation of follicular lymphoma and to clone the BCL2 gene. 28653191 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE We showed that DLBCL with MYC/BCL2-DH, and those with BCL2 translocation, harbour the characteristic mutation signatures that are associated with follicular lymphoma and its high-grade transformation. 31844144 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE Our analysis provided a novel look on the transition range between FL and DLBCL, on DLBCL with poor prognosis showing expression patterns resembling that of Burkitt's lymphoma and particularly on 'double-hit' MYC and BCL2 transformed lymphomas. 31039827 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE To clarify the characteristics of double-hit follicular lymphomas, we analyzed 10 cases of double-hit follicular lymphomas and 15 cases of high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements for clinicopathological and genome-wide copy-number alterations and copy-neutral loss-of-heterozygosity profiles. 28984304 2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE We focused on one of these miRNAs, namely <i>miR-150</i>, which was uniformly downmodulated in all examined tFLs (∼3.5-fold), and observed that high levels of MYC are responsible for repressing <i>miR-150</i> in tFL by binding in its upstream region. 30213873 2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE The most common scenario is transformation of follicular lymphoma to either diffuse large B-cell lymphoma or high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 translocations; however, other indolent subtypes such as marginal zone lymphoma, lymphoplasmacytic lymphoma, small lymphocytic lymphoma/chronic lymphocytic leukemia, or even nodular lymphocyte predominant Hodgkin lymphoma, can undergo similar histologic transformation. 30213394 2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE Fluorescence in situ hybridization (FISH) identified an IGH-BCL2 rearrangement in both the FL and high-grade B-cell components while a MYC rearrangement was detected in the high-grade B-cell component alone. 29793519 2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE A leukemic double-hit follicular lymphoma associated with a complex variant translocation, t(8;14;18)(q24;q32;q21), involving BCL2, MYC, and IGH. 29310838 2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Oligonucleotide sets that probe breakpoints of <i>IGH-BCL2</i> (immunoglobulin heavy-apoptosis regulator) in follicular lymphoma (FL), <i>MYC-IGH</i> (MYC proto-oncogene, bHLH transcription factor-immunoglobulin heavy) in Burkitt lymphoma (BL) and <i>BCR-ABL1</i> (RhoGEF and GTPase activating protein-ABL proto-oncogene 1, non-receptor tyrosine kinase) in chronic myelogenous leukemia (CML) were designed. 28515100 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE MYC breaks (MYC-R) were detected in eight of 21 (38%) tFLs analysed by fluorescence in-situ hybridization (FISH), with a median MYC score of 86%. 28730642 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE MYC/BCL2 double hit lymphoma (DHL) has been the subject of many studies; however, no study has systemically compared the clinicopathologic features and prognostic factors between patients with de novo disease versus those with a history of follicular lymphoma (FL). 27203548 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Follicular lymphoma with MYC and BCL2 translocations, so-called double-hit follicular lymphoma (DH-FL), is rare. 27544800 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Our limited experience showed that additional copy of intact MYC may be equivalent to "classic" DHL on the background of DLBCL with additional cytogenetic abnormalities, however isolated t(14;18)(q32;q21) translocation in combination with additional copy of intact MYC may demonstrate histology and clinical outcome more comparable with "classic" low grade follicular lymphoma, albeit with more aggressive morphology. 26464726 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE The detection of MYC protein expression in FL using IHC might be useful to predict more aggressive clinical course. 26261669 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE Mutations in epigenetic modifiers and antiapoptotic genes are introduced early in the common precursor, whereas tFL is specifically associated with alterations deregulating cell-cycle progression and DNA damage responses (CDKN2A/B, MYC, and TP53) as well as aberrant somatic hypermutation. 24388756 2014
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE We detected EZH2 mutations in 12/55 (22%) follicular lymphomas (FL), 5/35 (14%) diffuse large B cell lymphomas with a germinal center immunophenotype (GCB-DLBCL), and 2/11 (18%) high grade B cell lymphomas with concurrent rearrangements of BCL2 and MYC. 22194861 2011
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Moreover, FISH and molecular genetic study confirmed concomitant MYC translocations and t(14;18) in the high-grade component, thereby suggesting the transformation of atypical Burkitt's lymphoma from an undiagnosed antecedent follicular lymphoma. 21736761 2011
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE C-MYC rearrangements are common in FL-BT and may play a role in the progression from FL to FL-BT or the poor clinical outcomes observed. 21286717 2011
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangement. 21088162 2010
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Transformation from follicular lymphoma to high-grade B-cell lymphoma/leukemia with additional t(2;8)(p12;q24), with inverse expressions of c-MYC and BCL-2, and light-chain switch. 19351371 2009
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE Occurrence of ASHM in PIM-1, RhoH/TTF, and c-MYC was a constant finding in follicular lymphoma (FL) (all of 11 cases) but not so frequent in diffuse large B-cell lymphoma (DLBCL) (4 (33.3%) of 12 cases) and Marginal zone B-cell lymphoma (MZBCL) (1 (10.0%) of 10 cases). 19019431 2009
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE BCL2(+)/MYC(+) lymphomas were diagnosed as B-cell lymphoma unclassifiable (BCLU; n = 36) with features intermediate between Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL); DLBCL (n = 17), or follicular lymphoma (n = 1). 19597184 2009
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE This is a small series but one which raises the possibility that the presence of a C-MYC translocations at presentation may identify a particularly aggressive subtype of FL. 18297523 2008