|
HLA-DRB1
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
The most frequently observed haplotypes were A*02 B*35 DRB1*11 (7.50% vs. 1.89%) in HL patients, A*02 B*51 DRB1*11 (5.00% vs. 1.96%) in NHL patients, and A*02 B*35 DRB1*13 (2.19%) in the controls.
|
27063556 |
2016 |
|
HLA-DRB1
|
0.390 |
Biomarker
|
disease |
CTD_human |
Finally, control participants with either HLA-DRB1*01:01 or AH 8.1 reported having a family history of NHL twice as likely as those who did not have either allele or haplotype, providing the first empirical evidence that HLA associations may explain some of the well-established relationship between family history and NHL risk.
|
22096508 |
2011 |
|
HLA-DRB1
|
0.390 |
Biomarker
|
disease |
BEFREE |
Finally, control participants with either HLA-DRB1*01:01 or AH 8.1 reported having a family history of NHL twice as likely as those who did not have either allele or haplotype, providing the first empirical evidence that HLA associations may explain some of the well-established relationship between family history and NHL risk.
|
22096508 |
2011 |
|
HLA-DRB1
|
0.390 |
Biomarker
|
disease |
BEFREE |
Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008).
|
20385791 |
2010 |
|
HLA-DRB1
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that some genes in HLA-B*51-DRB1*09-DQB1*03 haplotype may contribute to NHL susceptibility in the Korean population.
|
18301962 |
2008 |
|
HLA-DRB1
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
In the current study, we have assigned most probable six-locus haplotypes determined by HLA-A, -Cw, -B and -DRB1 highly polymorphic genes and non-HLA LTA(+252) and TNF(-308) single nucleotide polymorphisms (SNPs) in 152 NHL Caucasian French patients.
|
17971052 |
2008 |
|
HLA-DRB1
|
0.390 |
Biomarker
|
disease |
BEFREE |
By contrast, the same allele as HLA-DRB1*04 showed an increase in HCV-associated NHL.
|
15556690 |
2004 |
|
HLA-DRB1
|
0.390 |
GeneticVariation
|
disease |
LHGDN |
By contrast, the same allele as HLA-DRB1*04 showed an increase in HCV-associated NHL.
|
15556690 |
2004 |
|
HLA-DRB1
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
(3) HLA-DRB1 *1302 and HLA-DQB1 *0502 and *0602 may confer protection to NHL.
|
15203870 |
2004 |
|
HLA-DRB1
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
To explore whether this could be linked to neighboring polymorphisms, we genotyped the TNF(-376,-308,-238,-163), lymphotoxin alpha (LTalpha)(+252), and HLA DRB1 alleles in 204 patients with NHL and 120 controls.
|
12351419 |
2002 |
|
HLA-DRB1
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
It is concluded that the DRB1*1502 allele may contribute to NHL susceptibility in the Thai population.
|
10583459 |
1999 |