Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4869
Gene Symbol: NPM1
NPM1
0.380 Biomarker disease BEFREE Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) involved in the genesis of several human cancers; indeed, ALK was initially identified in constitutively activated and oncogenic fusion forms--the most common being nucleophosmin (NPM)-ALK--in a non-Hodgkin's lymphoma (NHL) known as anaplastic large-cell lymphoma (ALCL) and subsequent studies identified ALK fusions in the human sarcomas called inflammatory myofibroblastic tumors (IMTs). 17694547 2008
Entrez Id: 4869
Gene Symbol: NPM1
NPM1
0.380 Biomarker disease BEFREE Chromosomal translocation t(2;5) and the resulting fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) are detected in 50% to 70% of anaplastic large cell lymphoma (ALCL), which is a T/null cell non-Hodgkin's lymphoma showing anaplastic morphology with cell surface expression of CD30. 16982741 2006
Entrez Id: 4869
Gene Symbol: NPM1
NPM1
0.380 GeneticVariation disease BEFREE The non-Hodgkin lymphoma (NHL) subtype anaplastic large-cell lymphoma (ALCL) is frequently associated with a t(2;5)(p23;q35) that results in the fusion of the ubiquitously expressed nucleophosmin (NPM) gene at 5q35 to the anaplastic lymphoma kinase (ALK) gene at 2p23, which is not normally expressed in hematopoietic tissues. 10706887 2000
Entrez Id: 4869
Gene Symbol: NPM1
NPM1
0.380 Biomarker disease BEFREE Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis. 9121481 1997
Entrez Id: 4869
Gene Symbol: NPM1
NPM1
0.380 GeneticVariation disease BEFREE Detection of the t(2;5)(p23;q35) and NPM-ALK fusion in non-Hodgkin's lymphoma by two-color fluorescence in situ hybridization. 9057650 1997
Entrez Id: 4869
Gene Symbol: NPM1
NPM1
0.380 GeneticVariation disease BEFREE Anaplastic Lymphoma Kinase (ALK) was originally identified as a member of the insulin receptor subfamily of receptor tyrosine kinases that acquires transforming capability when truncated and fused to nucleophosmin (NPM) in the t(2;5) chromosomal rearrangement associated with non-Hodgkin's lymphoma, but further insights into its normal structure and function are lacking. 9174053 1997
Entrez Id: 4869
Gene Symbol: NPM1
NPM1
0.380 Biomarker disease BEFREE The NPM/ALK-expressing cases were not confined to NHLs with anaplastic morphology and included 15 ALCLs, 6 immunoblastic lymphomas, and 10 diffuse large-cell lymphomas. 7780128 1995
Entrez Id: 4869
Gene Symbol: NPM1
NPM1
0.380 Biomarker disease BEFREE Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. 8122112 1994
Entrez Id: 4869
Gene Symbol: NPM1
NPM1
0.380 CausalMutation disease CGI