Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 843
Gene Symbol: CASP10
CASP10
0.730 GeneticVariation disease BEFREE Caspase-10 is an initiation-phase caspase, and somatic mutation of CASP10 that encodes caspase-10 has been found in non-Hodgkin's lymphoma and gastric carcinoma. 20025484 2010
Entrez Id: 843
Gene Symbol: CASP10
CASP10
0.730 GeneticVariation disease BEFREE We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3 [Ex8-280C>A (rs6948) and Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) and CASP10 Ex3-171A>G (rs3900115) to determine whether they alter risk for non-Hodgkin lymphoma (NHL) in a population-based case-control study of women in Connecticut (461 cases and 535 controls). 17071630 2007
Entrez Id: 843
Gene Symbol: CASP10
CASP10
0.730 GeneticVariation disease UNIPROT In this study, to explore the possibility that mutation of this gene might be involved in the development of non-Hodgkin lymphoma (NHL), we have analyzed the entire coding region and all splice sites of the CASP10 gene for the detection of somatic mutations in 117 human NHLs. 12010812 2002
Entrez Id: 843
Gene Symbol: CASP10
CASP10
0.730 GeneticVariation disease UNIPROT These data suggest that the inactivating mutations of the CASP10 gene might lead to the loss of its apoptotic function and contribute to the pathogenesis of some human NHLs. 12010812 2002
Entrez Id: 843
Gene Symbol: CASP10
CASP10
0.730 GeneticVariation disease LHGDN inactivating mutations in non-hodgkin lymphoma. 12010812 2002
Entrez Id: 843
Gene Symbol: CASP10
CASP10
0.730 CausalMutation disease CLINVAR In this study, to explore the possibility that mutation of this gene might be involved in the development of non-Hodgkin lymphoma (NHL), we have analyzed the entire coding region and all splice sites of the CASP10 gene for the detection of somatic mutations in 117 human NHLs. 12010812 2002
Entrez Id: 843
Gene Symbol: CASP10
CASP10
0.730 CausalMutation disease CLINVAR These data suggest that the inactivating mutations of the CASP10 gene might lead to the loss of its apoptotic function and contribute to the pathogenesis of some human NHLs. 12010812 2002
Entrez Id: 843
Gene Symbol: CASP10
CASP10
0.730 GeneticVariation disease UNIPROT Overall, 17 NHLs (14.5%) were found to have CASP10 mutations, which were identified in the coding regions of the prodomain (n = 3), the p17 large protease subunit (n = 11), and the p12 small protease subunit (n = 3). 12010812 2002
Entrez Id: 843
Gene Symbol: CASP10
CASP10
0.730 CausalMutation disease CLINVAR Overall, 17 NHLs (14.5%) were found to have CASP10 mutations, which were identified in the coding regions of the prodomain (n = 3), the p17 large protease subunit (n = 11), and the p12 small protease subunit (n = 3). 12010812 2002
Entrez Id: 843
Gene Symbol: CASP10
CASP10
0.730 GeneticVariation disease BEFREE These data suggest that the inactivating mutations of the CASP10 gene might lead to the loss of its apoptotic function and contribute to the pathogenesis of some human NHLs. 12010812 2002
Entrez Id: 843
Gene Symbol: CASP10
CASP10
0.730 CausalMutation disease CLINVAR Inactivating mutations of the caspase-10 gene in gastric cancer. 11973654 2002
Entrez Id: 843
Gene Symbol: CASP10
CASP10
0.730 Biomarker disease CTD_human
Entrez Id: 843
Gene Symbol: CASP10
CASP10
0.730 CausalMutation disease CGI