Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Kras activation and Pten deletion are observed in intestinal-type gastric cancer, and Cdh1 mutation is associated with diffuse-type gastric cancer. 30168144 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE The -472delA (rs5030625) and -160C>A (rs16260) polymorphisms in CDH1 induce a decrease in gene transcription; in fact, these mutated alleles have been associated with GC in some populations, with conflicting results. 27706737 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Gastric cancer (GC) is considered to be one of the leading cancers in East Asians, and mutations in the CDH1 gene and the reduced expression of E-cadherin are the most frequent genetic alterations in gastric cancer. 23435907 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Familial diffuse type gastric cancer occurs due to germ-line mutations of the CDH1 gene. 16273224 2005
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE The poorly cohesive histology/CDH1-mutant GC subgroup showed the worst survival (p < 0.001). 30801717 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Inactivation of the E-cadherin gene in sporadic diffuse-type gastric cancer. 11598162 2001
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE A great number of genes with promoter methylation have been observed in gastric cancer (GC), among which p16INK4A (p16), Mut L homologue 1 (MLH1), Epithelial-cadherin (E-cadherin), Runt-related transcription factor 3 (RUNX3), adenomatous polyposis coli (APC), O(6)-methylguanine-DNA methyltransferase (MGMT), Ras association domain family 1A (RASSF1A) and Death-associated protein kinase (DAPK) have been extensively studied. 22936446 2012
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Analysis of HDGC patients harbouring CDH1 alleles with PTCs at a wide variety of different positions indicates an association of their predicted ability to induce NMD and an earlier age of onset of gastric cancer. 18427545 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE No associations between CDH1 (+54T>C, -160C>A, -347G>GA, -616G>C, -2076C>T and -3159T>C) gene polymorphisms and GC risk for all genetic models were found. 21570316 2011
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE We have shown that germline CDH1 mutations are associated with early onset of bilateral LCIS with or without ILC in women without a family history of gastric cancer. 24366306 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 PosttranslationalModification disease BEFREE CDH1 gene promoter hypermethylation in gastric cancer: relationship to Goseki grading, microsatellite instability status, and EBV invasion. 16531765 2006
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE All individuals with a CDH1 mutation had a personal or family history of diffuse gastric cancer. 26072394 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 PosttranslationalModification disease BEFREE E-cadherin promoter hypermethylation induced by interleukin-1beta treatment or H. pylori infection in human gastric cancer cell lines. 18249489 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE CDH1 associated gastric cancer: a report of a family and review of the literature. 15780560 2005
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Hereditary diffuse gastric cancer is caused by germline mutations in the epithelial cadherin (CDH1) gene and is characterized by an increased risk for diffuse gastric cancer and lobular breast cancer. 17545690 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE In our area, in which a high rate of familial aggregation was demonstrated, the lack of germ line mutation of TP53 together with the infrequency of mutation of E-cadherin gene seem to limit the role of genetic predisposition in the development of gastric cancer. 19674071 2010
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Furthermore, the CDH1 c.1679C>G (p.T560R) variant segregated with gastric cancer in all three family members affected with gastric cancer in this family. 27880784 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE CIHM of CDH1 and DAP-kinase in non-neoplastic gastric mucosa corresponded to a risk of GC regardless of histological subtype, H. pylori infection status, gender and generation. 20150736 2010
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE We screened all exons of the E-cadherin gene for mutations in 101 Japanese patients having an intense family history of gastric cancers. 12604719 2003
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Endoscopic Ultrasound Has Limited Utility in Diagnosis of Gastric Cancer in Carriers of CDH1 Mutations. 31077828 2020
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Using polymerase chain reaction (PCR)/single-strand conformation polymorphism (SSCP)/sequencing, we screened 32 Portuguese families with a history of gastric cancer and 23 patients with early onset gastric cancer for CDH1 germline mutations. 15288293 2004
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 AlteredExpression disease BEFREE The E-cadherin protein expression level in gastric cancer tissues was significantly lower than that in the adjacent normal tissues (p < 0.05). 22581441 2012
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Overall, 78% of GC cases harbored one clinically relevant GA or more, with the most frequent alterations being found in TP53 (50%), ARID1A (24%), KRAS (16%), CDH1 (15%), CDKN2A (14%), CCND1 (9.5%), ERBB2 (8.5%), PIK3CA (8.6%), MLL2 (6.9%), FGFR2 (6.0%), and MET (6.0%). 25882375 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE CDH1 germ-line missense mutation identified by multigene sequencing in a family with no history of diffuse gastric cancer. 25981591 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE These results suggest that the ATCTG and CTTTG CDH1 haplotypes may be associated with an increased risk and decreased risk, respectively, of GC in the Japanese population. 17852867 2007