Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE PD-L1 membrane expression on tumour cells (TC) and infiltrating immune cells (IC), CD3 + T-lymphocytes, CD8+ cytotoxic T-cells, ATM and HER2 were assessed by immunohistochemistry (IHC) in the ACRG (Asian Cancer Research Group) GC cohort (N = 380). 30729066 2019
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 AlteredExpression disease BEFREE Furthermore, CENPO knockdown decreased ataxia telangiectasia mutated (ATM), cyclin D1 and c‑Jun expression, indicating that the ATM signaling pathway may be involved in CENPO‑mediated regulation of GC cell growth. 31485675 2019
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 AlteredExpression disease BEFREE HOXC10 promoted GC cell invasion and migration, regulated the expression of activated ATM and markers of NF-κB signaling. 29753747 2018
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation disease BEFREE The clinical significance of PD-L1 in advanced gastric cancer is dependent on <i>ARID1A</i> mutations and ATM expression. 30221053 2018
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE ATM was downregulated in GC patients in Xinjiang, especially for Uygurs and Kazaks, which suggested ATM to be an independent indicator of prognosis for GC therapy. 28647209 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE Further clinical studies on the interaction between AZD 6738 and ATM deficiency are warranted to develop novel treatment strategies for gastric cancer.<i></i>. 28138034 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE Although ATM was shown to be associated with poor prognosis in gastric cancer, its implications as a predictive biomarker for cancer chemotherapy remain unexplored. 27638859 2016
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE Gemcitabine was found to be a lytic inducer via activation of the ataxia telangiectasia-mutated (ATM)/p53 genotoxic stress pathway in EBVaGC. 26427042 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation disease BEFREE Loss-of-function variants in ATM confer risk of gastric cancer. 26098866 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease CTD_human We found a new gastric cancer association with loss-of-function mutations in ATM (gene test, P = 8.0 × 10(-12); odds ratio (OR) = 4.74). 26098866 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE In addition, data revealed hsa-let-7 g miRNA increased the sensitivity of GC to X-rays involving in ATM regulation as well according to application of X-rays (another DDR inducer). 25972194 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE Intra-Tumoral Heterogeneity of HER2, FGFR2, cMET and ATM in Gastric Cancer: Optimizing Personalized Healthcare through Innovative Pathological and Statistical Analysis. 26587992 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation disease BEFREE Further evaluation of ATM mutations in hereditary gastric cancer will facilitate genetic testing and risk assessment. 26506520 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 AlteredExpression disease BEFREE There was inverse correlation between miR-181a and ATM protein expression in gastric cancer and normal gastric tissues. 24531888 2014
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 AlteredExpression disease BEFREE Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. 24841718 2014
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 AlteredExpression disease BEFREE Ataxia-telangiectasia-mutated protein expression with microsatellite instability in gastric cancer as prognostic marker. 23649938 2014
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation disease BEFREE Two human GC cell lines (SNU-1 and -638) showed ATM intron mutations, deletion in RT-PCR and direct sequencing, and ATM protein loss by IHC. 24324828 2013
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE Expression loss of breast cancer type 1 susceptibility protein (BRCA1), ataxia telangiectasia mutated (ATM), ATM-Rad3-related (ATR), mediator of DNA damage checkpoint protein 1 (MDC1) and meiotic recombination 11 (Mre11) were correlated with their clinicopathological parameters in gastric cancer (GC). 23569343 2013
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE Cytotoxicity of 5-Aza-2'-deoxycytidine against gastric cancer involves DNA damage in an ATM-P53 dependent signaling pathway and demethylation of P16(INK4A). 23201008 2013
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE Our findings suggest that ATM mutations might be a pathogenic factor for an increased risk of gastric cancer, and the dysfunction of ATM may lead to a hypersensitivity to ionizing radiation in gastric cancer cells, possibly by a p53-dependent pathway. 14706517 2004
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation disease BEFREE No evidence for constitutional ATM mutation in breast/gastric cancer families. 9592204 1998
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GenomicAlterations disease CGI
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 CausalMutation disease CGI