Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 Biomarker disease BEFREE RT-qPCR was used to detect the expression of MT1JP, miR-214-3p and RUNX3 in tumor tissues and cell lines of GC. 29742512 2018
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 AlteredExpression disease BEFREE The pooled data showed that expression of RUNX3 was significant correlated with tumor's differentiation (OR = 0.387; 95%CI: 0.237-0.633; P = 0.000), depth of invasion (OR = 0.443; 95%CI: 0.273-0.717; P = 0.001), lymph node metastasis (OR = 0.394; 95%CI: 0.259-0.598; P = 0.000), distant metastasis (OR = 0.403; 95%CI: 0.213-0.764; P = 0.005) and TNM stage (OR = 0.461; 95%CI, 0.322-0.659; P = 0.000) in GC. 29578091 2018
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 Biomarker disease BEFREE In addition to gene mutation and promoter hypermethylation, cytoplasmic mislocalization has emerged as another major manifestation of RUNX3 dysfunction in malignancies including breast, colorectal and gastric cancers. 29545901 2018
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 Biomarker disease BEFREE Runt-related transcription factor 3 (Runx3) is an important transcription factor that functions as a tumor suppressor in gastric cancer. 29417297 2018
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 Biomarker disease BEFREE RUNX3 inhibits the proliferation and metastasis of gastric cancer through regulating miR-182/HOXA9. 29054094 2017
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 Biomarker disease BEFREE The Relationship between RUNX3 Expression, Nursing Strategies and Nutritional Status in Elderly Patients with Advanced Gastric Cancer. 28828318 2017
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 Biomarker disease BEFREE Combined Detection of Plasma ZIC1, HOXD10 and RUNX3 Methylation is a Promising Strategy for Early Detection of Gastric Cancer and Precancerous Lesions. 28529617 2017
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 PosttranslationalModification disease BEFREE Methylation of RUNX3 promoter was significantly higher in GC than normal subjects. 27664488 2016
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 PosttranslationalModification disease BEFREE The RUNX3 gene promoter methylation rate was much higher in tumor tissue than that in normal gastric tissue in patient with gastric cancer, which indicates a close association between gastric cancer and RUNX3 gene promoter methylation. 27721253 2016
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 Biomarker disease BEFREE RUNX3 showed protein silencing in cancer and normal mucosa, compared to inflammatory peritumoural infiltrate in almost all cases, showing a non-lymphocytic predominant pattern and being correlated with epigenetic silencing.Our results show aberrant promoter's methylation in APC, CDH1, CDKN2A, MLH1 and RUNX3 associated with GC, as well as a non-lymphocytic predominant infiltrate with high expression of RUNX3. 27566570 2016
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 AlteredExpression disease BEFREE We also found that miR-532-5p level was negatively correlated with RUNX3 gene expression in various GC cell lines. 26515139 2016
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 AlteredExpression disease BEFREE More than a decade ago claims arose that the RUNX3 member of the RUNX transcription factor family is a major TSG inactivated in gastric cancer, a postulate extended later to other cancers. 25641675 2015
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 PosttranslationalModification disease BEFREE Finally, via long-term culture of gastric tumour epithelium, we revealed that de novo methylation of the RUNX3 canonical CGI promoter is a bystander effect of oncogenic immortalization and not likely causal in GC pathogenesis as previously argued. 25088199 2015
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 Biomarker disease BEFREE Furthermore, the expression of miR‑130a in plasma in gastric cancer patients was upregulated and diagnostic value for gastric cancer of miR-130a is more effective than the tumor markers carcinoembryonic antigen (CEA) and CA-199. miR-130a directly targeted runt‑related transcription factor 3 (RUNX3) and promoted gastric cancer tumorigenesis by targeting RUNX3. miR-130a may therefore be a useful marker for the diagnosis and prognosis of gastric cancer. 26134263 2015
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 Biomarker disease BEFREE These findings reveal a novel mechanism of RUNX3 for the induction of cell apoptosis in human gastric cancer. 24636883 2014
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 AlteredExpression disease BEFREE Thus, RUNX3 suppressed gastric cancer cell invasion and vimentin expression by activating miR-30a. 24447545 2014
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 PosttranslationalModification disease BEFREE A systematic review and meta-analysis of runt-related transcription factor 3 gene promoter hypermethylation and risk of gastric cancer. 25693942 2014
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 AlteredExpression disease BEFREE MicroRNA-148a can regulate runt-related transcription factor 3 gene expression via modulation of DNA methyltransferase 1 in gastric cancer. 23549984 2013
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 AlteredExpression disease BEFREE Furthermore, similar inverse trends between RUNX3 and OPN messenger RNA (mRNA) expression were demonstrated in six out of seven normal-tumor-paired gastric cancer clinical specimens. 23774402 2013
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 Biomarker disease BEFREE These results provide further evidence that RUNX3 can function as a tumor suppressor and suggest that practical methods to augment RUNX3 function could be useful in treating of some types of gastric cancer. 23230322 2013
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 Biomarker disease BEFREE The frequencies of high-level methylation in GC tissues for the seven genes were: 48% for APC, 57.33% for WIF-1, 56% for RUNX-3, 50.67% for DLC-1, 52% for SFRP-1, 54.67% for DKK, and 48% for E-cad. 23049225 2012
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 Biomarker disease BEFREE A great number of genes with promoter methylation have been observed in gastric cancer (GC), among which p16INK4A (p16), Mut L homologue 1 (MLH1), Epithelial-cadherin (E-cadherin), Runt-related transcription factor 3 (RUNX3), adenomatous polyposis coli (APC), O(6)-methylguanine-DNA methyltransferase (MGMT), Ras association domain family 1A (RASSF1A) and Death-associated protein kinase (DAPK) have been extensively studied. 22936446 2012
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 AlteredExpression disease BEFREE The negative correlation of RUNX3 and Akt expression and downstream β-catenin/cyclin D1 effectors was further confirmed in AGS and GES-1 cell lines, as well as clinical specimens of gastric cancer. 22231444 2012
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 PosttranslationalModification disease BEFREE The levels of RUNX3 methylation in serum were in significant concordance with the methylation levels observed in GC tissues (P = .887). 22576578 2012
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
0.400 Biomarker disease BEFREE Runt-related transcription factor 3 (RUNX3) is a tumor suppressor of gastric cancer. 21135153 2011