Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease BEFREE Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer. 28460635 2018
Entrez Id: 4233
Gene Symbol: MET
MET
0.700 GeneticVariation disease BEFREE Circulating tumor DNA profiling by next generation sequencing reveals heterogeneity of crizotinib resistance mechanisms in a gastric cancer patient with MET amplification. 28460431 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease BEFREE Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR. 29443099 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Up to 10% of cases of gastric cancer are familial, but so far, only mutations in CDH1 have been associated with gastric cancer risk. 28024868 2017
Entrez Id: 4233
Gene Symbol: MET
MET
0.700 Biomarker disease BEFREE This study was conducted to investigate whether human epidermal growth factor receptor 2 (HER2) status, epidermal growth factor receptor (EGFR) status, and c-MET status are independent prognostic factors for advanced gastric cancer patients who received standard chemotherapy. 25682441 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE A prospective gastric cancer database identified 41 patients with CDH1 mutation who underwent total gastrectomy during 2005 to 2015. 27759617 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE Digital PCR identifies changes in CDH1 (E-cadherin) transcription pattern in intestinal-type gastric cancer. 27861150 2017
Entrez Id: 4233
Gene Symbol: MET
MET
0.700 AlteredExpression disease BEFREE Finally, we observed an inverse correlation between the expression of miR-144 and MET mRNA in GC metastatic tissues. 25927670 2016
Entrez Id: 4233
Gene Symbol: MET
MET
0.700 Biomarker disease BEFREE In this study, we focused on frequencies of EGFR, ErbB2 and MET gene amplification in gastric cancer patients to develop personalized medicine to improve the treatment. 25820598 2016
Entrez Id: 4233
Gene Symbol: MET
MET
0.700 Biomarker disease BEFREE Identification of short-form RON as a novel intrinsic resistance mechanism for anti-MET therapy in MET-positive gastric cancer. 26528757 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease BEFREE The clinicopathological significance of CDH1 in gastric cancer: a meta-analysis and systematic review. 25926721 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE The updated guidelines include revised CDH1 testing criteria (taking into account first-degree and second-degree relatives): (1) families with two or more patients with gastric cancer at any age, one confirmed DGC; (2) individuals with DGC before the age of 40 and (3) families with diagnoses of both DGC and LBC (one diagnosis before the age of 50). 25979631 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE Epigenetic regulation of CDH1 exon 8 alternative splicing in gastric cancer. 26674321 2016
Entrez Id: 4233
Gene Symbol: MET
MET
0.700 AlteredExpression disease BEFREE Targeting gastric cancers with amplified or abnormally activated MET may have therapeutic benefit based on nonclinical and emerging clinical findings. 26543351 2016
Entrez Id: 4233
Gene Symbol: MET
MET
0.700 Biomarker disease BEFREE Human cancer cell lines and gastric cancer tissue microarrays were examined for MET amplification by fluorescence in situ hybridization (FISH). 26879245 2016
Entrez Id: 4233
Gene Symbol: MET
MET
0.700 Biomarker disease BEFREE These findings indicate that the miR-1/MET pathway is a potential therapeutic target due to its crucial role in gastric cancer cell proliferation and migration. 25874496 2016
Entrez Id: 4233
Gene Symbol: MET
MET
0.700 Biomarker disease BEFREE We also showed that HOTAIR recruiting and binding to PRC2 epigenetically represses miR34a, which controls the targets C-Met (HGF/C-Met/Snail pathway) and Snail, thus contributing to GC cell-EMT process and accelerating tumor metastasis. 26136075 2016
Entrez Id: 4233
Gene Symbol: MET
MET
0.700 Biomarker disease BEFREE The frequencies of gene amplifications in advanced gastric cancers were as follows: ERBB2 (13 cases, 14%), FGFR2 (7 cases, 8%), MYC (7 cases, 8%), TOP2A (7 cases, 8%), MET (4 cases, 4%), MDM2 (4 cases, 4%), CCND1 (3 cases, 3%), FGF10 (2 cases, 3%), and EGFR (1 case, 1%). 25743022 2016
Entrez Id: 4233
Gene Symbol: MET
MET
0.700 Biomarker disease BEFREE Volitinib, a potent and highly selective c-Met inhibitor, effectively blocks c-Met signaling and growth in c-MET amplified gastric cancer patient-derived tumor xenograft models. 25248999 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE CDH1 was downregulated in diffuse-type GC tissues (P=0.0007) and showed a negative relationship with HOTAIR (r(2)=0.154, P=0.0354). 26136075 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE For patients with an identified germline E-cadherin-1 (CDH1) mutation, prophylactic gastrectomy is the treatment of choice to eliminate the high risk of developing diffuse gastric cancer. 26443527 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer. 26334097 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 PosttranslationalModification disease BEFREE Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, affecting cell migration and invasion in gastric cancer. 25874772 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Lack of association between the CDH1 polymorphism and gastric cancer susceptibility: a meta-analysis. 25599647 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene. 23812922 2015