Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE Further, meta-analysis revealed significant association of IL-1β rs1143627: T > C (p = 0.026; OR = 4.165; 95% CI 1.18-14.65) and rs16944: C > T (p = 0.01; OR = 5.49; 95% CI 1.48-20.37) in presence of H. pylori with gastric cancer in Asian population though no significant difference (p > 0.05) was found when compared to absence of H. pylori . 30094865 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 AlteredExpression disease BEFREE IFN-γ and IL-10 levels were significantly higher in early (I/II) and late stage (III/IV) gastric cancer; IL-1β and IL-8 were higher and MCP-1 was lower only in late stage (IV) patients. 28558708 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE The pro-inflammatory cytokine IL-1β plays a crucial role in the development of gastric tumors, and polymorphisms in the IL-1 gene cluster resulting in increased IL-1β production have been associated with increased risk for gastric cancer. 27460807 2016
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE Subgroup analysis showed a significant correlation between IL-1β-511C/T polymorphism and susceptibility to gastric cancer in residents of southern China and in patients with intestinal-type gastric cancer, but not in residents of northern China or in patients with diffuse gastric cancer. 27215350 2016
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE Furthermore, H. pylori infection has a synergistic effect on the development of GC with IL-1β gene polymorphisms, and the highest prevalence of severe gastric abnormalities are found in patients with both host and bacterial high-risk genotypes (cagA(+)/vacAs1(+)/IL-1β-511T). 27076787 2016
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 Biomarker disease BEFREE Disruption of the HNF4α/IL-1R1/IL-1β/NF-κB circuit during Hp infection maybe an effective means of preventing the associated GC. 26870992 2016
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE Based on subgroup analysis, H. pylori infection and genotype analysis using PCR-RFLP methods increase the association between IL-1β-511 T allele carrier and risk of stomach cancer. 25258120 2015
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 Biomarker disease BEFREE In this retrospective cohort study we genotyped 154 patients with gastric cancer for IL-1β and IL-1RN variations. 24557417 2015
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE These results suggested that SNPs in the IL-1 family genes play important roles in the development of GC and the IL-1F5 might be the target gene of miR-197, and miR-197 might negatively regulate its expression. 26632693 2015
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 AlteredExpression disease BEFREE IL-1β stimulated uPA expression through ERK and NF-κB in gastric cancer, which may therefore be promising targets for gastric cancer therapy. 24626561 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE The proinflammatory cytokine IL-1β plays a crucial role in the development of gastric tumors and polymorphisms in the IL-1 gene cluster leading to increased IL-1β production have been associated with increased risk for gastric cancer. 25172489 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 PosttranslationalModification disease BEFREE IL-1β may be an important mediator for H. pylori induced gene methylation during GC development. 24023501 2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE Our results demonstrated that the IL-1β -511 C/C and IL-1β -511 C/T alleles were associated with chronic gastritis in H. pylori-positive patients (P = 0.04 and P = 0.05, respectively) and the IL-1β -511 C/C genotype was associated with GC (P = 0.03). 22714811 2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE Moderate to high Cap consumption synergistically increased GC risk in genetically susceptible individuals (IL1B-31C allele carriers) infected with the more virulent H. pylori (CagA+) strains. 22414649 2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE In the Chinese subgroup, nominally significant associations were shown between (i) EBBR2+1963G (rs1801200) and H. pylori infection (per-allele OR: 0.48, 95% CI 0.23, 0.98, P = 0.04), (ii) PTGS2-1195G (rs689466) and an increased risk of GC on adjusting for H. pylori status (OR: 1.53, 95% CI 0.99, 2.37, P = 0.05), and (iii) IL1B-1473C (rs1143623) and a decreased risk of GC (OR: 0.64, 95% CI 0.41, 0.99, P = 0.05). 21649724 2011
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 AlteredExpression disease BEFREE Functionally, 2 RUNX3 isoforms may contribute differentially to intestinal-type gastric cancer susceptibility, at least in part through regulating NF-κB activity and IL1B expression. 21523770 2011
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE So far, a number of association studies have focused on the effect of polymorphisms in IL-1β and TNF-α genes on the susceptibility to gastric cancer (GC). 21246243 2011
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE These findings suggest that the IL1B-511T/T allele is associated with enhanced hypermethylation of multiple CpG island loci, which might contribute to an increase in the risk for gastric cancer in individuals with H. pylori infection and IL1B-511T/T allele. 20405297 2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE The distribution of the four major IL1B variants (IL1B-3737C>T, -1464G>C, - 511C>T, -31T>C) were analyzed in 116 and 142 patients with gastric cancer and 'high risk gastritis', respectively, as well as 94 healthy controls. 20332462 2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE Interleukin 1-beta gene polymorphisms and risk of gastric cancer in Sweden. 19031173 2009
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in Helicobacter pylori-infected Peruvians. 19861615 2009
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE Multivariate regression analysis showed that cagE, babA2, and IL-1RN-1/2 genotypes were independent predictors of GC, but when patients with benign disorders were grouped together (NUD + DU) and compared with patients with GC, regression analysis disclosed that babA2 (P = 0.000) and IL-1B-31 gene polymorphisms (CC or CT) (P = 0.01) were the only independent markers of GC. 18807132 2008
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE It has been reported that interleukin-1beta (IL-1B) genes play a crucial role in the genetic predisposition to gastric cancer although there is no information about their role in different subtypes of gastric cancer. 18688641 2008
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 GeneticVariation disease BEFREE Our findings confirm the correlation between the IL1beta-511T allele polymorphism and gastric cancer risk in the overall population. 18949424 2008
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.500 Biomarker disease BEFREE Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer. 17201881 2007