Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.030 Biomarker disease BEFREE This suggests the possible role of multidrug resistance (MDR), albeit atypical (which means it does not involve the usual MDR1 and MRP glycoproteins), in medulloblastoma's CP-resistance. 18473730 2008
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.030 Biomarker disease BEFREE Drug-resistance genes messenger ribonucleic acid (mRNA) expressions were investigated in drug-resistant human glioma cell lines derived from U87MG and 46 frozen samples of retrospectively examined neuroepithelial tumors (12 low grade neuroepithelial tumors, 16 Grade III gliomas, 11 glioblastomas, and 7 other malignant neuroepithelial tumors such as medulloblastomas and primitive neuroectodermal tumors) by RT-PCR with the specific primers for O6-methylguanine DNA methyltransferase (MGMT), multidrug-resistance gene 1 (MDR1), multidrug-resistance-associated protein (MRP), and glutathione-S-transferase-pi (GST-pi). 10894369 2000
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.030 AlteredExpression disease BEFREE mRNA expression of ABCB1 increased together with augmenting concentration and time of exposure to vinblastine for R286, UW467, and UW3 cell lines. 18946672 2009
Entrez Id: 4363
Gene Symbol: ABCC1
ABCC1
0.040 AlteredExpression disease BEFREE The MRP1 gene was preferentially expressed by medulloblastomas (P = 0.04) and ependymomas (P = 0.04); ependymomas also presented an increase of LRP (P = 0.02). 17429576 2007
Entrez Id: 4363
Gene Symbol: ABCC1
ABCC1
0.040 AlteredExpression disease BEFREE High expression of MRP1 (89%, 8/9 tumors), TUBB3 (86%, 18/21 tumors), PTEN (85%, 28/33 tumors), TOP2A (84%, 26/31 tumors), thymidylate synthase (TS; 80%, 24/30 tumors), RRM1 (71%, 15/21 tumors), and TOP1 (63%, 19/30 tumors) were found in medulloblastoma. 29869738 2018
Entrez Id: 4363
Gene Symbol: ABCC1
ABCC1
0.040 Biomarker disease BEFREE This suggests the possible role of multidrug resistance (MDR), albeit atypical (which means it does not involve the usual MDR1 and MRP glycoproteins), in medulloblastoma's CP-resistance. 18473730 2008
Entrez Id: 4363
Gene Symbol: ABCC1
ABCC1
0.040 Biomarker disease BEFREE Drug-resistance genes messenger ribonucleic acid (mRNA) expressions were investigated in drug-resistant human glioma cell lines derived from U87MG and 46 frozen samples of retrospectively examined neuroepithelial tumors (12 low grade neuroepithelial tumors, 16 Grade III gliomas, 11 glioblastomas, and 7 other malignant neuroepithelial tumors such as medulloblastomas and primitive neuroectodermal tumors) by RT-PCR with the specific primers for O6-methylguanine DNA methyltransferase (MGMT), multidrug-resistance gene 1 (MDR1), multidrug-resistance-associated protein (MRP), and glutathione-S-transferase-pi (GST-pi). 10894369 2000
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
0.010 Biomarker disease BEFREE Drug-resistance genes messenger ribonucleic acid (mRNA) expressions were investigated in drug-resistant human glioma cell lines derived from U87MG and 46 frozen samples of retrospectively examined neuroepithelial tumors (12 low grade neuroepithelial tumors, 16 Grade III gliomas, 11 glioblastomas, and 7 other malignant neuroepithelial tumors such as medulloblastomas and primitive neuroectodermal tumors) by RT-PCR with the specific primers for O6-methylguanine DNA methyltransferase (MGMT), multidrug-resistance gene 1 (MDR1), multidrug-resistance-associated protein (MRP), and glutathione-S-transferase-pi (GST-pi). 10894369 2000
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.010 Biomarker disease BEFREE Inhibition of SUR1 may result in neuronal stabilization in glioblastoma, cerebral metastases, and posterior fossa ependymoma and reduced edema in medulloblastoma.. 30079884 2019
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.020 Biomarker disease BEFREE Using flow cytometry, we isolated 2.9% of cancer stem-like SP cells from malignant medulloblastoma, which was reduced to 0.4% in the presence of verapamil, an inhibitor of ABC transporter. 25966102 2015
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.020 AlteredExpression disease BEFREE ABCG2 expression was influenced by vinblastine only for UW3. 18946672 2009
Entrez Id: 29
Gene Symbol: ABR
ABR
0.010 GeneticVariation disease BEFREE This report provides new physical mapping data for the ABR gene, which has not been previously shown to be deleted in medulloblastoma. 7829075 1994
Entrez Id: 43
Gene Symbol: ACHE
ACHE
0.010 Biomarker disease BEFREE A major band of 2.5 kb was labeled with ACHE cDNA in poly(A)+ RNA blots from medulloblastoma cells or brain tissue, whereas a PCR-amplified probe from the inserted domain labeled a 3.4-kb band but not the 2.5-kb band in poly(A)+ RNA from small cell lung carcinoma. 8299725 1994
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
0.010 AlteredExpression disease BEFREE G-protein coupled receptor expression patterns delineate medulloblastoma subgroups. 24252460 2013
Entrez Id: 55
Gene Symbol: ACP3
ACP3
0.010 Biomarker disease BEFREE Ecto-5'-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model. 26491983 2015
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.010 Biomarker disease BEFREE MB with myogenic differentiation and MB cases showing variable immunoreactivity with the above 3 antibodies were further evaluated for smooth muscle actin, desmin, myogenin, and HMB45. 29412177 2018
Entrez Id: 101
Gene Symbol: ADAM8
ADAM8
0.010 AlteredExpression disease BEFREE Detection of ADAM8 expression might facilitate the prognostic assessment and improve the therapeutic strategy for medulloblastoma patients. 22959284 2012
Entrez Id: 575
Gene Symbol: ADGRB1
ADGRB1
0.020 Biomarker disease BEFREE Knockout of Adgrb1 in mice augments proliferation of cerebellar granule neuron precursors, and leads to accelerated tumor growth in the Ptch1<sup>+/-</sup> transgenic MB mouse model. 29894688 2018
Entrez Id: 575
Gene Symbol: ADGRB1
ADGRB1
0.020 AlteredExpression disease BEFREE Taken together, our results identify key molecular players that regulate ADGRB1 gene expression in MB, demonstrate that reactivation of BAI1 expression underlies EPZ-6438 antitumorigenic action, and provide preclinical proof-of-principle evidence for targeting EZH2 in patients with MB. 31582835 2020
Entrez Id: 148
Gene Symbol: ADRA1A
ADRA1A
0.010 AlteredExpression disease BEFREE G-protein coupled receptor expression patterns delineate medulloblastoma subgroups. 24252460 2013
Entrez Id: 151
Gene Symbol: ADRA2B
ADRA2B
0.010 AlteredExpression disease BEFREE G-protein coupled receptor expression patterns delineate medulloblastoma subgroups. 24252460 2013
Entrez Id: 173
Gene Symbol: AFM
AFM
0.010 Biomarker disease BEFREE Mechanical indentation using AFM on sliced human brain tissues (medulloblastoma, grade IV) revealed that the mechanical properties of this tissue are strongly heterogeneous, between 1.8 and 75.7kPa, and the mean of 27.16kPa. 28688336 2018
Entrez Id: 196
Gene Symbol: AHR
AHR
0.010 Biomarker disease BEFREE Therefore, this study evaluated whether the AhR serves a pro-proliferative role in an immortalized MB tumor cell line (DAOY). 22311706 2012
Entrez Id: 10598
Gene Symbol: AHSA1
AHSA1
0.020 Biomarker disease BEFREE These findings suggest p38 inhibition as a potential way to increase the efficacy of treatments available for malignancies associated with deregulated SHH signaling, such as basal cell carcinoma and medulloblastoma. 22302101 2012
Entrez Id: 10598
Gene Symbol: AHSA1
AHSA1
0.020 Biomarker disease BEFREE Our study establishes the functional significance of EAG2 in promoting MB tumor progression via regulating cell volume dynamics, the perturbation of which activates the tumor suppressor p38 MAPK pathway, and provides clinical relevance for targeting this ion channel in human MBs. 22855790 2012