Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1
0.370 Biomarker disease CTD_human On the basis of this knowledge, we demonstrate how the loss of RASSF1A function in medulloblastoma cells might be overcome using the novel BH3-only mimetic ABT-737 in combination with chemotherapeutic agents to target the BCL-2 anti-apoptotic members. 21880625 2012
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1
0.370 Biomarker disease BEFREE On the basis of this knowledge, we demonstrate how the loss of RASSF1A function in medulloblastoma cells might be overcome using the novel BH3-only mimetic ABT-737 in combination with chemotherapeutic agents to target the BCL-2 anti-apoptotic members. 21880625 2012
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1
0.370 Biomarker disease CTD_human Here, we demonstrate that expression of RASSF1A promotes the induction of cell death after activation of both the extrinsic and intrinsic apoptotic pathways in medulloblastoma cells. 21880625 2012
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1
0.370 GeneticVariation disease BEFREE Although the methylation frequency found in MB was slightly higher than in sPNET, no statistical differences were found for the RASSF1A hypermethylation frequency (P > 0.05) presented at MB versus sPNET. 17899687 2007
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1
0.370 PosttranslationalModification disease BEFREE The frequency of promoter hypermethylation of RASSF1A was significantly lower in SPNETs than in MBs (Fisher exact test, P = .014). 16311119 2006
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1
0.370 AlteredExpression disease BEFREE Treatment of cell lines using 5-Aza-2'-deoxycytidine (5AZA) alone or in combination with trichostatin A (TSA) succeeded in re-establishing expression of RASSF1A in cell lines derived from a renal rhabdoid, an AT/RT and a medulloblastoma. 16186793 2006
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1
0.370 PosttranslationalModification disease BEFREE These data therefore indicate that extensive methylation of RASSF1A, HIC1 and CASP8 are tumour-specific events in medulloblastoma. 14688019 2004
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1
0.370 Biomarker disease BEFREE Methylation of the promoter CpG islands of the RASSF1A may play an important role in the pathogenesis of glioma and medulloblastoma. 14586413 2003
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1
0.370 PosttranslationalModification disease BEFREE Furthermore, RASSF1A hypermethylation is a frequent event in medulloblastoma tumorigenesis detectable in adult (5 of 7) and pediatric patients (22 of 27) and in all histological variants and age and sex groupings. 12384556 2002