Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE In addition, OTX2 expression might be a predictive factor for leptomeningeal metastases of medulloblastoma. 30797919 2019
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 Biomarker disease BEFREE Our study provides mechanistic insight into the networks controlled by OTX2 in MB stem/progenitor cells and reveals novel roles for axon guidance genes and their downstream effectors as putative tumor suppressors in MB. 29377567 2018
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE PRUNE1 is highly expressed in metastatic medulloblastoma group 3, which is characterized by TGF-β signalling activation, c-MYC amplification, and OTX2 expression. 29490009 2018
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE OTX2 is overexpressed in all types of medulloblastomas, except in Shh-dependent type 2 medulloblastomas, although it has GCPs as cell-of-origin. 30100614 2018
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE Our studies thus show that OTX2 controls the regulatory landscape of Group 3 medulloblastoma through cooperative activity at enhancer elements and contributes to the expression of critical target genes.<b>Significance:</b> The gene regulation mechanisms that drive medulloblastoma are not well understood. 28213356 2017
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 Biomarker disease BEFREE Involvement of the Otx2 gene dysfunction in both group 4 subtype medulloblastoma and mirror-image dextrocardia with situs inversus points to a possible mechanism that dysfunction of a shared signaling pathway such as Otx2 might be the underlying cause of these 2 conditions in this family. 28844926 2017
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE Recent studies have revealed that Group 3 and Group 4 medulloblastomas show marked overexpression of OTX2 with a concurrent amplification of the MYC and MYCN oncogenes, respectively, correlating with anaplasticity and unfavorable patient outcomes. 28401018 2017
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 Biomarker disease BEFREE By contrast, OTX2 is oncogenic and promotes self-renewal of trans-hENs and Groups 3 and 4 MB independent of pluripotent gene expression. 26398939 2015
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE Five differentially expressed genes in medulloblastoma (GLI1, SPHK1, SHROOM2, PDLIM3, and OTX2) were found to associate with Hh pathway activation status. 25473003 2015
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE OTX2, an oncogenic miR-206 target, overexpressed in all non-SHH medulloblastomas, is known to inhibit myogenic differentiation of medulloblastoma cells. 25859932 2015
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 Biomarker disease BEFREE Moreover, OTX2 is a known oncogenic driver in medulloblastoma, a condition that was diagnosed in the proband during the course of the study. 24816892 2014
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE This work characterizes for the first time the mechanisms of OTX2 overexpression in medulloblastoma. 25198066 2014
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 Biomarker disease BEFREE Silencing of OTX2 in D425 medulloblastoma cells resulted in downregulation of polycomb genes such as EZH2, EED, SUZ12 and RBBP4 and upregulation of H3K27 demethylases KDM6A, KDM6B, JARID2 and KDM7A. 23179372 2013
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 GeneticVariation disease BEFREE Recent studies have also established the OTX2 gene as an oncogene for medulloblastoma, a malignant brain tumour originating in the cerebellum. 23523800 2013
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE Here we have sought to determine the functional consequences of Otx2 overexpression in the mouse hindbrain to characterize its potential role in medulloblastoma tumorigenesis and identify the cell types responsive to this lineage-specific oncogene. 22558385 2012
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE Conversely, inducing myogenic conversion of medulloblastoma cells led to the loss of OTX2 expression. 22986744 2012
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 Biomarker disease BEFREE We generated D425 medulloblastoma cells in which endogenous OTX2 can be silenced by inducible shRNA. 21964830 2012
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE Our data suggest an important functional interaction between OTX2 and MYC in regulating gene expression in medulloblastoma. 22016811 2011
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 Biomarker disease BEFREE Our findings define OTX2 as an important oncogenic driver in medulloblastoma. 20028867 2010
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE We therefore generated MED8A and DAOY medulloblastoma cell lines with doxycycline-inducible OTX2 expression. 21047732 2010
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 Biomarker disease CTD_human Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. 19270706 2009
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE In 15 cases, we also examined expression of OTX2, a transcription factor recently indicated as a positive marker of medulloblastomas originating from cerebellar granule precursors. 17522332 2007
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE Immunohistochemical analysis of a series of classic medulloblastomas detected OTX2 protein expression in 83 of 107 (78%) cases. 16462208 2006
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 Biomarker disease LHGDN OTX2 transcript was highly and specifically expressed in medulloblastoma or developing cells. 15705863 2005
Entrez Id: 5015
Gene Symbol: OTX2
OTX2
0.400 AlteredExpression disease BEFREE OTX2 transcript was highly and specifically expressed in medulloblastoma or developing cells. 15705863 2005