Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE The results show that dasatinib exerts synergistic effects with cisplatin in human medulloblastoma cells through the inhibition of STAT3 and Src. 30332965 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Together these data identify STAT3 as a key molecule underpinning the sexual dimorphism in medulloblastoma. 31683879 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Furthermore, it also upregulated the expression of phosphorylated STAT3, indicating that the IL‑6/GP130/STAT3 pathway plays a central role in medulloblastoma. 29207075 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Furthermore, combination therapy with S3-NTDi and cisplatin significantly decreased highly aggressive MYC-amplified MB cell growth and induced apoptosis by downregulating STAT3 regulated proliferation and anti-apoptotic gene expression. 29280516 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE The signal transducers and activators of transcription-3 (STAT3) pathway are selectively activated in CD133<sup>+</sup> MBSCs and promote tumorigenesis through regulation of c-MYC, a key genetic driver of Group 3 MB. 27775079 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE In line with these findings we show for MYC-amplified medulloblastoma a profound reduction in activity of the oncogenes STAT3 and AKT. 28159923 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE In resveratrol-suppressed medulloblastoma cells with STAT3 downregulation and decreased incidence of STAT3 nuclear translocation, PIAS3 is upregulated, the SHP2 level remains unchanged and SOCS3 is downregulated. 28035977 2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 PosttranslationalModification disease BEFREE LY5 inhibited persistent STAT3 phosphorylation and induced apoptosis in human medulloblastoma cell lines expressing constitutive STAT3 phosphorylation. 25313399 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Taken together our studies further reveal that STAT3 plays a key role in SPARC induced G2/M arrest in medulloblastoma cells. 22206672 2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Our results suggest that LLL12 is a potent STAT3 inhibitor and that it may be a potential therapeutic treatment for medulloblastoma and glioblastoma. 21526200 2011
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE However, Bcl-2, a common target of STAT3 and NF-κB signaling, is distinctly up-regulated in resveratrol-treated medulloblastoma cells, indicating potential effects of NF-κB in Bcl-2 expression and anti-medulloblastoma efficiency of resveratrol. 21161674 2011
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE High levels of activated/phosphorylated STAT3 were also present in cultured human malignant glioma and medulloblastoma cells. 18829483 2008
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease CTD_human Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas. 19001435 2008
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease LHGDN To further ascertain the significance of STAT3 signaling for medulloblastoma cells, AG490, a selective inhibitor of STAT3 phosphorylation, was used to treat UW228-3 cells. 18592012 2008
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells. 18592012 2008