Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease BEFREE Further, the expression of murine homolog of miR-206 was also found to be downregulated in SHH subgroup medulloblastomas from the Smo (+/+) transgenic mice and the Ptch1 (+/-) knockout mice. 25859932 2016
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease BEFREE Using Ptch1(+/-) mice to study medulloblastoma progression, we found that Ptch1 loss of heterozygosity (LOH) is an early event that is associated with high levels of cell senescence in preneoplasia. 26997276 2016
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 GeneticVariation disease BEFREE This is supported by the observation that human medulloblastomas with PTCH1 mutations displayed more similarities to PTCH1 wild-type tumors of the same age group than to PTCH1-mutated tumors of the other age group. 24871706 2015
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 GeneticVariation disease BEFREE Each SUFU-positive family included a single case of medulloblastoma, whereas only two (1.7%) of 115 individuals with Gorlin syndrome and a PTCH1 mutation developed medulloblastoma. 25403219 2015
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease BEFREE Together, our results indicate that DNA damage promoted by Boc leads to the demise of its own coreceptor, Ptch1, and consequently medulloblastoma progression. 25263791 2015
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease BEFREE Treatment of Med in Ptch1(+/-) Trp53(-/-) mice with the antiestrogen chemotherapeutic drug Faslodex significantly increased symptom-free survival, which was associated with increased apoptosis and decreased BCL2 and IGF1R expression and signaling. 25885794 2015
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease BEFREE Simultaneous deletion of Zfx along with Ptch1 prevented BCC formation and delayed medulloblastoma development. 25164012 2014
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease BEFREE By combining SB mutagenesis with Patched1 heterozygous mice (Ptch1(lacZ/+)), we observed an increased frequency of MB and decreased tumor-free survival compared with Ptch1(lacZ/+) controls. 24167280 2014
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease BEFREE If one copy of the Ptch gene is lost, as in human Gorlin's syndrome and in Ptch(+/-) mice, MBs may form. 23389290 2013
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 GeneticVariation disease BEFREE Abnormal activation of components of the Hedgehog pathway--specifically, resulting from mutations in the Patched 1 gene--is associated with the development of basal cell carcinoma, as well as several other cancers, including medulloblastoma. 22177103 2012
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 GeneticVariation disease BEFREE Novel PTCH1 mutations in Japanese Nevoid basal cell carcinoma syndrome patients: two familial and three sporadic cases including the first Japanese patient with medulloblastoma. 21368767 2011
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 GeneticVariation disease BEFREE We also briefly review two important advances in this area: the treatment of medulloblastomas in patients with mutations in the PTCH1 gene, and the discovery of deregulated mammalian target of rapamycin as a major oncogenic driver molecule in patients with TSC mutations and subependymal giant cell astrocytoma. 21042217 2011
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease MGD Protective role of 17 β-estradiol on medulloblastoma development in Patched 1 heterozygous mice. 21351254 2011
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease MGD Susceptibility to MB development was significantly increased in ovariectomized Ptch1(+/-) females and restored to levels observed in control mice after estrogen replacement. 21351254 2011
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 GeneticVariation disease BEFREE Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma. 21188540 2011
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 GeneticVariation disease BEFREE Whereas genetic mutations in PTCH1 have previously been shown to lead to medulloblastoma, our study indicates that epigenetic silencing of PTCH1, and other critical developmental loci, by DNA methylation is a fundamental process of pediatric medulloblastoma formation. 19966297 2010
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease BEFREE The IGF-I transgene produced a marked brain overgrowth, and significantly accelerated tumor development, increasing the frequency of pre-neoplastic lesions as well as full medulloblastomas in Ptc1+/-/IGF-I Tg mice. 20214787 2010
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease BEFREE Primary tumor cells derived from two models of murine medulloblastoma (Ptch1(+/-);Ink4c(-/-) and p53(FL/FL);Nestin-Cre(+); Ink4c(-/-)) that retain and lack p53 function, respectively, displayed a dependence on functional p53 to engage 17-DMAG-induced apoptosis. 19805107 2010
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease MGD Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. 19185848 2009
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease BEFREE Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma. 19147535 2009
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease CTD_human Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice. 19155313 2009
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 GeneticVariation disease BEFREE We have identified the known c.1022 + 1G>A SUFU germ line splicing mutation in a family that was PTCH1-negative and who had signs and symptoms of GS, including medulloblastoma. 19533801 2009
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease CTD_human Patched1 (Ptc1) was one of the first such loci, and Ptc1 haploinsufficiency has been asserted to lead to medulloblastoma and rhabdomyosarcoma in mice. 19213072 2009
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease BEFREE To study the role of Ptc1 in cerebellar tumor development and to create a preclinical therapeutic platform, we have generated a conditional Ptc1 haploinsufficiency model of medulloblastoma by inactivating Ptc1 in Pax7-expressing cells of the cerebellum. 19213072 2009
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.900 Biomarker disease CTD_human To study the role of Ptc1 in cerebellar tumor development and to create a preclinical therapeutic platform, we have generated a conditional Ptc1 haploinsufficiency model of medulloblastoma by inactivating Ptc1 in Pax7-expressing cells of the cerebellum. 19213072 2009