Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.540 Biomarker disease PSYGENET An interaction between BDNF and ELS increased the risk of non-melancholia by 3.327, whereas the interaction between 5-HTT and ELS increased risk by 2.406. 22247094 2012
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.540 GeneticVariation disease BEFREE Key findings indicated that BDNF and 5-HTT polymorphisms in combination with ELS contributed to the development of non-melancholic depression. 22247094 2012
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.540 Biomarker disease CTD_human Estradiol and progesterone modify the effects of the serotonin reuptake transporter polymorphism on serotonergic responsivity to citalopram. 21843009 2011
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.540 Biomarker disease PSYGENET Norepinephrine and serotonin transporter genes: impact on treatment response in depression. 20588071 2010
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.540 Biomarker disease CTD_human Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. 18458677 2009
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.540 GeneticVariation disease BEFREE Also, the more active 5-HTTLPR/5-HTT rs25531 haplotype L(A)L(A) conveyed a significant risk for melancholic depression (OR 2.0; 95%CI 1.3-3.1; P=0.001), again only in the female subsample of patients (OR 2.1; 95%CI 1.1-4.1; P=0.02). 18050262 2008
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.540 Biomarker disease PSYGENET Also, the more active 5-HTTLPR/5-HTT rs25531 haplotype L(A)L(A) conveyed a significant risk for melancholic depression (OR 2.0; 95%CI 1.3-3.1; P=0.001), again only in the female subsample of patients (OR 2.1; 95%CI 1.1-4.1; P=0.02). 18050262 2008
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.540 Biomarker disease CTD_human The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposure. 18686203 2008
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.540 Biomarker disease PSYGENET Melancholic depression was associated with the 5-HTTLPR long (l) allele and atypical depression with the 5-HTTLPR s-allele (two-sided Fisher's exact test: genotype distribution: P=0.0038; allele frequencies: P=0.007). 14593433 2003
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.540 Biomarker disease CTD_human Regional serotonin transporter availability and depression are correlated in Wilson's disease. 12898347 2003
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.540 GeneticVariation disease BEFREE Melancholic depression was associated with the 5-HTTLPR long (l) allele and atypical depression with the 5-HTTLPR s-allele (two-sided Fisher's exact test: genotype distribution: P=0.0038; allele frequencies: P=0.007). 14593433 2003
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.540 GeneticVariation disease BEFREE According to these results, variability in the SERT gene has a small effect on liability to MDDM. 9799087 1998
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.540 Biomarker disease PSYGENET According to these results, variability in the SERT gene has a small effect on liability to MDDM. 9799087 1998
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.350 GeneticVariation disease BEFREE The aim of our study was to (a) test for an association between the BDNF Val66Met polymorphism and childhood-onset melancholic depression and (b) to examine the interactive effects of stressful life events (SLE) and the Val66Met polymorphism on the risk of childhood-onset melancholic depression. 26462036 2015
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.350 GeneticVariation disease BEFREE Val66Met BDNF genotypes in melancholic depression: effects on brain structure and treatment outcome. 23165919 2013
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.350 GeneticVariation disease BEFREE Recent post hoc analyses indicated a potential association of three polymorphisms in the BDNF gene with worse treatment outcome in patients with the subtype of melancholic depression. 22965830 2013
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.350 GeneticVariation disease BEFREE Key findings indicated that BDNF and 5-HTT polymorphisms in combination with ELS contributed to the development of non-melancholic depression. 22247094 2012
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.350 Therapeutic disease CTD_human Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: effects of fluoxetine and MK-801. 21945287 2012
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.350 Biomarker disease CTD_human Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: effects of fluoxetine and MK-801. 21945287 2012
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.350 GeneticVariation disease BEFREE However, BDNF rs7103411 and rs6265 similarly predicted worse treatment response over 6 wk in clinical subtypes of depression such as melancholic depression only (rs7103411: TT < CC, p = 0.003; rs6265: GG < AA, p = 0.001). 19236730 2010
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.350 Biomarker disease CTD_human Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats. 16330021 2006
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.350 Therapeutic disease CTD_human Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats. 16330021 2006
Entrez Id: 5443
Gene Symbol: POMC
POMC
0.310 GeneticVariation disease BEFREE The following search items were used: "hypothalamic-pituitary-adrenal" OR "HPA" OR "cortisol" OR "corticotropin releasing hormone" OR "corticotropin releasing factor" OR "glucocorticoid*" OR "adrenocorticotropic hormone" OR "ACTH" AND "atypical depression" OR "non-atypical depression" OR "melancholic depression" OR "non-melancholic depression" OR "endogenous depression" OR "endogenomorphic depression" OR "non-endogenous depression". 29150144 2018
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.310 Biomarker disease BEFREE The following search items were used: "hypothalamic-pituitary-adrenal" OR "HPA" OR "cortisol" OR "corticotropin releasing hormone" OR "corticotropin releasing factor" OR "glucocorticoid*" OR "adrenocorticotropic hormone" OR "ACTH" AND "atypical depression" OR "non-atypical depression" OR "melancholic depression" OR "non-melancholic depression" OR "endogenous depression" OR "endogenomorphic depression" OR "non-endogenous depression". 29150144 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.310 Biomarker disease BEFREE No association between polymorphisms and haplotypes of the AVPR1b, CRHR1 and NR3C1 genes and depression with melancholic features in the course of bipolar disorder. 23068076 2013