Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 AlteredExpression disease BEFREE We showed that ectopic MCL1 expression rescued apoptosis of MM. 31653349 2020
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE Preclinical evaluation of the simultaneous inhibition of MCL-1 and BCL-2 with the combination of S63845 and venetoclax in multiple myeloma. 31320555 2020
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE This work led to the discovery of <b>1</b>, a potent Mcl-1 inhibitor (IC<sub>50</sub> = 19 nM in an OPM-2 cell viability assay) with good pharmacokinetic properties and excellent in vivo efficacy in an OPM-2 multiple myeloma xenograft model. 31736296 2019
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 PosttranslationalModification disease BEFREE Co-culture experiments resulted in MDSC-induced AMPK phosphorylation in MM cells, which was associated with an increase in the anti-apoptotic factors MCL-1 and BCL-2, and the autophagy-marker LC3II. 30419344 2019
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 AlteredExpression disease BEFREE In myeloma, in vitro sensitivity to venetoclax is mainly observed in plasma cells harboring the t(11;14) translocation, a molecular subgroup associated with high Bcl-2 and low Mcl-1/Bcl-XL expression. 30076373 2018
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE Multiple myeloma is considered to be a disease dependent mainly on MCL1 for survival, based mostly on studies using cell lines. 30309889 2018
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 AlteredExpression disease BEFREE ABT-199 is a specific Bcl-2 inhibitor in clinical trials for MM; however, its activity as a single agent was limited to myeloma patients with the t(11;14) translocation who acquire resistance due to co-expression of Mcl-1 and Bcl-xL. 29761903 2018
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE Our studies demonstrate that AZD5991 binds directly to Mcl-1 and induces rapid apoptosis in cancer cells, most notably myeloma and acute myeloid leukemia, by activating the Bak-dependent mitochondrial apoptotic pathway. 30559424 2018
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE Members of MCL1-M captured both MM cell-intrinsically acting signals and the signals regulating the interaction between MM cells with bone marrow microenvironment. 29696703 2018
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE Expression of pro-survival BCL-2 family protein MCL-1 is essential for survival of malignant PC in multiple myeloma (MM). 30524962 2018
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 AlteredExpression disease BEFREE MCL-1 ectopic expression or knockdown in MM cells significantly diminished or increased ABT-199 sensitivity, respectively. 29241222 2018
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE In conclusion, the NEAT1/miR-193a/MCL1 pathway is closely associated with the development of DEX resistance in myeloma cells, and knockdown of NEAT1 can significantly improve DEX sensitivity in MM. 29205703 2018
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE We used the Bcl-2/Bcl-x<sub>L</sub> inhibitor ABT-737 to study the factors regulating whether myeloma is Mcl-1 dependent, and thus resistant to ABT-737-induced apoptosis, or Bcl-2/Bcl-x<sub>L</sub> codependent, and thus sensitive to ABT-737. 28151428 2017
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 AlteredExpression disease BEFREE Mcl-1 was up-regulated in all MM lines tested, including bortezomib-resistant lines, human MM xenograft mouse models, and primary CD138<sup>+</sup> MM cells. 28938651 2017
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE The antiapoptotic proteins BCL-2 and myeloid cell leukemia sequence 1 (MCL-1) promote multiple myeloma (MM) cell survival. 28847998 2017
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 AlteredExpression disease BEFREE Venetoclax is a selective, orally bioavailable BCL-2 inhibitor that induces cell death in multiple myeloma (MM) cells, particularly in those harboring t(11;14), which express high levels of BCL-2 relative to BCL-X<sub>L</sub> and MCL-1. 29018077 2017
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 AlteredExpression disease BEFREE We show that our lead compound (compound 20) decreases glucose uptake and cell proliferation as well as inhibits the expression of pro-survival MCL-1 in MM similar to the effect observed via knockdown of GLUT4 expression. 28837922 2017
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 AlteredExpression disease BEFREE IHC of multiple myeloma patient bone marrow biopsies and aspirates (n = 95) revealed high levels of BCL-2 and BCL-XL in 62% and 43% of evaluable samples, respectively, while 34% were characterized as BCL-2(High)/BCL-XL (Low) In addition to MCL-1, our data suggest that BCL-XL may also be a potential resistance factor to venetoclax monotherapy and in combination with bortezomib. 26939706 2016
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE These findings underscore the implication of the Mcl-1/Bak axis in myeloma cell death triggered by Thapsigargin. 27697610 2016
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE We also identified a previously unrecognized subset of myeloma that is highly BCLXL-dependent, and has the potential for cotargeting MCL1 and BCLXL. 27465916 2016
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE In conclusion, our data demonstrate that soluble factors from MM cells are able to generate MDSC through Mcl-1 upregulation and this cell population can be considered as a possible target in MM disease. 25871384 2015
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE Usp24 was found to sustain myeloma cell survival and Mcl-1 regulation in the absence of Usp9x. 25814533 2015
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 AlteredExpression disease BEFREE Ritonavir and metformin effectively suppressed AKT and mTORC1 phosphorylation and prosurvival BCL-2 family member MCL-1 expression in multiple myeloma cell lines in vitro and in vivo. 25542900 2015
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE Furthermore, previous studies demonstrated that proteasome inhibitors induce Mcl-1 accumulation that, in turn, slows down their pro-apoptotic effects, and the cell survival in multiple myeloma is highly dependent on Mcl-1. 25812695 2015
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.400 Biomarker disease BEFREE miR-137 and miR-197 Induce Apoptosis and Suppress Tumorigenicity by Targeting MCL-1 in Multiple Myeloma. 25724519 2015