Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.370 AlteredExpression disease BEFREE Taken together, our results indicate that increased CCL2 expression in MM patients' BM polarizes Mφs toward the M2-like phenotype and promotes the protective effect of Mφs through MCPIP1, providing novel insight into the mechanism of Mφs-mediated drug resistance in MM. 31611552 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.370 Biomarker disease BEFREE We found that distinct to full length CCL2 or its N-truncated derivative (CCL2 5-76), GMME1 bound to CCR2 on mouse lymphoma EG7, human multiple myeloma cell line U266, or murine and human medulloblastoma cell lines, and led to their death by apoptosis. 21943176 2011
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.370 Biomarker disease CTD_human CCL2 may be involved in MM pathobiology by tumor growth suppression. 16918137 2006
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.370 Biomarker disease BEFREE CCL2 may be involved in MM pathobiology by tumor growth suppression. 16918137 2006
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.370 Biomarker disease BEFREE Bone marrow endothelial cells (EC) from patients with multiple myeloma (MM) were found to express and secrete higher amounts of the CXC-chemokines CXCL8/interleukin (IL)-8, CXCL11/interferon-inducible T-cell alpha chemoattractant (I-TAC), CXCL12/stromal cell-derived factor (SDF)-1alpha, and CCL2/monocyte chemotactic protein(MCP)-1 than EC from human umbilical vein (HUVEC), considered as a healthy counterpart. 15813853 2005
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.370 Biomarker disease BEFREE In summary, our data clearly support additional investigations using anti-MCP-1 antibodies in myeloma progression. 15041705 2004
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.370 Biomarker disease BEFREE In addition, we found that the monocyte chemotactic proteins (MCPs) MCP-1, -2 and -3, three chemokines acting as prominent ligands for CCR2, are produced by stromal cells, cultured from normal and MM BM samples. 12644822 2003
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.370 Biomarker disease BEFREE Moreover, we also demonstrated IL-6 stimulated MCP-1 secretion by the myeloma cell lines as well as by fresh patient tumor cells. 12357369 2002